“…14,40 Focusing solely on biology, depression may partially be the consequence of physiological abuse-related changes in brain structures (eg, corpus collosum, hippocampus, amygdala) and the HPA axis, which ultimately impacts behavior and mood. 55,70 For instance, dysregulation of the HPA axis results in increased cortisol levels, which can lead to the breakdown of serotonin, an important neurotransmitter in the regulation of mood. 40 Depression is often identified as an outcome of abuse; however, it may also influence the extent to which abuse adversely impacts a woman's physical health, thereby positioning it as a mediator between abuse and physical health.…”