A review of neosporosis and pathologic findings of Neospora caninum infection in wildlife

Donahoe, Shannon L.; Lindsay, Scott A.; Krockenberger, M. B.; Phalen, David N.; Šlapeta, Jan

doi:10.1016/j.ijppaw.2015.04.002

Cited by 169 publications

(194 citation statements)

References 220 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…17 Neosporosis abortion or neonatal illness is known to occur in a variety of large herbivores, including goat, sheep, llama, alpaca, several species of deer, lesser kudu, horse, and white rhinoceros. 3 Naturally occurring Neospora parasitism, but mostly without reports of disease, have been detected in adults of many other species of wild, feral, captive, and domestic animals, including rodents, lagomorphs, kangaroos, sparrows, parrots, and chickens. The possibility that these animals may serve as efficient intermediate hosts of the parasite, inducing patent infections when they are eaten by canids, is plausible but speculative.…”

Section: Neosporosis In Other Domestic Animals and In Wildlifementioning

confidence: 99%

“…Maintaining a closed herd cannot guarantee freedom from infection because the causative parasite may be transmitted in feedstuffs or water, and the parasite naturally cycles within wildlife. 3 Critically, brucellosis and leptospirosis are zoonotic, whereas neosporosis is not. Furthermore, neosporosis is seldom if ever a cause of regional or international trade restrictions, unlike brucellosis, bovine pestivirus, and bovine herpesvirus.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Diagnosis and Control of Bovine Neosporosis

McAllister

2016

Veterinary Clinics of North America: Food Animal Practice

View full text Add to dashboard Cite

Section: Neosporosis In Other Domestic Animals and In Wildlifementioning

confidence: 99%

mentioning

confidence: 99%

Diagnosis and Control of Bovine Neosporosis

McAllister

2016

Veterinary Clinics of North America: Food Animal Practice

View full text Add to dashboard Cite

“…N. caninum is an apicomplexan parasite closely related to Toxoplasma gondii , which infects a wide intermediate host range (3, 4). As an important veterinary pathogen, several researches have been focused on N. caninum in the past two decades.…”

Section: Introductionmentioning

confidence: 99%

Canine Neutrophil Extracellular Traps Release Induced by the Apicomplexan Parasite Neospora caninum In Vitro

et al. 2016

View full text Add to dashboard Cite

Neosporosis is considered as one of the main causes of abortion and severe economic losses in dairy industry. The Canis genus serving as one of the confirmed definitive hosts of the apicomplexan parasite Neospora caninum (N. caninum) plays a critical role in its life cycle. However, the effects of N. caninum on its definitive hosts of neutrophils extracellular traps (NETs) formation remain unclear. In the present study, N. caninum tachyzoite-induced canine NETs formation was observed by scanning electron microscopy (SEM). Visualization of DNA decorated with H3, neutrophil elastase (NE), and myeloperoxidase (MPO) within N. caninum tachyzoite-induced NETs were examined using fluorescence confocal microscopy analyses. Furthermore, the formation of canine NETs was quantified using Sytox Green staining, and the LDH levels in supernatants were examined by an LDH Cytotoxicity Assay® kit. The results clearly showed that NETs-like structures were induced by N. caninum tachyzoites, and the major components within these structures induced by N. caninum tachyzoite were further confirmed by fluorescence confocal microscopy visualization. These results suggest that N. caninum tachyzoites strongly induced NETs formation in canine polymorphonuclear neutrophils (PMN). In functional inhibition assays, the blockings of NADPH oxidase, NE, MPO, SOCE, ERK 1/2, and p38 MAPK signaling pathways significantly inhibited N. caninum tachyzoite-induced NETs formation. To our knowledge, this study is the first to report the formation of NETs in canine PMN against N. caninum infection.

show abstract

“…zoonotic and mainly causes disease in cattle and dogs (2,5). In most immunocompetent species, N. caninum and T. gondii infections are subclinical and severe disease is uncommon (3,5).…”

mentioning

confidence: 99%

“…In most immunocompetent species, N. caninum and T. gondii infections are subclinical and severe disease is uncommon (3,5).…”

mentioning

confidence: 99%

Differential Gamma Interferon- and Tumor Necrosis Factor Alpha-Driven Cytokine Response Distinguishes Acute Infection of a Metatherian Host with Toxoplasma gondii and Neospora caninum

et al. 2017

Self Cite

View full text Add to dashboard Cite

Toxoplasma gondii and Neospora caninum (both Apicomplexa) are closely related cyst-forming coccidian parasites that differ significantly in their host ranges and ability to cause disease. Unlike eutherian mammals, Australian marsupials (metatherian mammals) have long been thought to be highly susceptible to toxoplasmosis and neosporosis because of their historical isolation from the parasites. In this study, the carnivorous fat-tailed dunnart (Sminthopsis crassicaudata) was used as a disease model to investigate the immune response and susceptibility to infection of an Australian marsupial to T. gondii and N. caninum. The disease outcome was more severe in N. caninuminfected dunnarts than in T. gondii-infected dunnarts, as shown by the severity of clinical and histopathological features of disease and higher tissue parasite burdens in the tissues evaluated. Transcriptome sequencing (RNA-seq) of spleens from infected dunnarts and mitogen-stimulated dunnart splenocytes was used to define the cytokine repertoires. Changes in mRNA expression during the time course of infection were measured using quantitative reverse transcription-PCR (qRT-PCR) for key Th1 (gamma interferon KEYWORDS apicomplexan parasites, cytokines, real-time PCR, transcriptomics N eospora caninum and Toxoplasma gondii (Apicomplexa: Coccidia) are tissue cystforming parasites with a worldwide distribution. Although these closely related parasites share some similar morphological and biological features, they exhibit key differences in host range and pathogenicity (1, 2). Toxoplasma gondii is regarded as one of the most successful parasites due to its capacity to infect and cause disease in essentially any mammalian or avian species (3). In humans, it is also considered a pathogen of particular significance for pregnant and immunocompromised individuals (3, 4). In contrast, N. caninum is capable of infecting many different species but is not

show abstract

A review of neosporosis and pathologic findings of Neospora caninum infection in wildlife

Abstract: HighlightsThe importance of Neospora caninum-associated disease in wildlife is reviewed.There are only 12 reports of clinical neosporosis in wildlife species to date.The best practice guidelines to follow for reporting wildlife cases of neosporosis are presented.

Cited by 169 publications

References 220 publications

Diagnosis and Control of Bovine Neosporosis

Diagnosis and Control of Bovine Neosporosis

Canine Neutrophil Extracellular Traps Release Induced by the Apicomplexan Parasite Neospora caninum In Vitro

Differential Gamma Interferon- and Tumor Necrosis Factor Alpha-Driven Cytokine Response Distinguishes Acute Infection of a Metatherian Host with Toxoplasma gondii and Neospora caninum

Contact Info

Product

Resources

About