A review of implantable biosensors for closed-loop glucose control and other drug delivery applications

Scholten, Kee; Meng, Ellis

doi:10.1016/j.ijpharm.2018.02.022

Cited by 74 publications

(71 citation statements)

References 177 publications

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“…To date, the biggest challenge of the implantable glucose sensors is how to improve the sensitivity while maintain good linearity, biocompatibility and lifetime [5,35]. There are several ways to solve this problem, including maximizing sensing surface of the electrode; reducing the negative effects of oxygen deficiency; balancing high sensitivity and wide linear detection range; increasing the signal to noise ratio; and, maintaining the stability of the sensor for a long time.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus [1] is one of the pandemics characterized by chronic hyperglycemia [2], which seriously threatens human physical and mental health and quality of life. Since no cure has been developed for this disease, maintaining euglycemia through diet, exercise and pharmacological management is a way to prevent diabetic complications [3][4][5]. Currently, continuous glucose monitoring systems (CGMS) are increasingly popular, since they can reflect fluctuation of blood glucose (BG), easily perceive asymptomatic hypoglycemia and relieve the pain of sticking fingers frequently for people with diabetes [2,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…The minimally invasive implantable glucose sensor is a key module that affects the performance of CGMS [8]. The sensitivity, biocompatibility, stability and linear measuring range of the implantable sensors are important to the entire system [5]. Glucose oxidase (GOD) can be easily prepared, and has strong specificity to glucose, high activity and stability, which is widely applied in amperometric glucose sensor [9].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, both of the two ways succeed at the cost of sensitivity decreasing. The decline of the signal-to-noise ratio also increases the difficulty of signal acquisition in following hardware circuit, and hinders the promotion and low-cost mass production of CGMS [5].…”

Section: Introductionmentioning

confidence: 99%

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Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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This study aims to develop an oxygen regeneration layer sandwiched between multiple porous polyurethanes (PU) to improve the performance of implantable glucose sensors. Sensors were prepared by coating electrodes with platinum nanoparticles, Nafion, glucose oxidase and sandwich hierarchically porous membrane with an oxygen supplement function (SHPM-OS). The SHPM-OS consisted of a hierarchically porous structure synthesized by polyethylene glycol and PU and a catalase (Cat) layer that was coated between hierarchical membranes and used to balance the sensitivity and linearity of glucose sensors, as well as reduce the influence of oxygen deficiency during monitoring. Compared with the sensitivity and linearity of traditional non-porous (NO-P) sensors (35.95 nA/mM, 0.9987, respectively) and single porous (SGL-P) sensors (45.3 nA /mM, 0.9610, respectively), the sensitivity and linearity of the SHPM-OS sensor was 98.45 nA/mM and 0.9989, respectively, which was more sensitive with higher linearity. The sensor showed a response speed of five seconds and a relative sensitivity of 90% in the first 10 days and remained 78% on day 20. This sensor coated with SHPM-OS achieved rapid responses to changes of glucose concentration while maintaining high linearity for long monitoring times. Thus, it may reduce the difficulty of back-end hardware module development and assist with effective glucose self-management for people with diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

et al. 2020

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“…Implantable biosensors have been developing to be used not only as a monitoring system of the biorhythms, [ 49 ] but also as a drug release system for the treatment of cancers or endocrine diseases including diabetes. [ 51 ] In the near future, these implantable devices are expected to be important tools for human electronic identification, internal body monitoring and also prevention or treatment of diseases. Nevertheless, after decades of market experience with animals, the intrabody mobility (i.e., migration) of the current injectable RFID tag is still a problem.…”

Section: Figurementioning

confidence: 99%

Titanium as an Instant Adhesive for Biological Soft Tissue

Okada

Hara

Yabe

et al. 2020

Adv Materials Inter

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A variety of polymer‐ and ceramic‐based soft‐tissue adhesives have been developed as alternatives to surgical sutures, yet several disadvantages regarding the mechanical properties, biocompatibility, and handling hinder their further application particularly when applied for immobilization of implantable devices. Here, it is reported that a biocompatible and tough metal, titanium (Ti), shows instant and remarkable adhesion properties after acid treatment, demonstrated by ex vivo shear adhesion tests with mouse dermal tissues. Importantly, in vivo experiments demonstrate that the acid‐treated Ti can easily and stably immobilize a device implanted in the mouse subcutaneous tissue. Collectively, the acid‐treated Ti is shown as a solid‐state instant adhesive material for biological soft tissues, which can have diverse applications including immobilization of body‐implantable devices.

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Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

Zhang

Chen

Shi

et al. 2020

Adv Funct Materials

161

139

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Foreign‐body response caused by implanted biomaterials seriously impedes the function of implants and is a major obstacle to the development of implantable biomaterials and medical devices. Recent advances in implantable biomaterials and medical devices have provided strategies to resist the foreign‐body response. In this review, the mechanism of the foreign‐body response and conventional strategies to mitigate foreign‐body response is briefly introduced. Then, three types of promising foreign‐body response resisting materials are focused and the advantages, characteristics, and applications of each material are discussed. Finally, prospects are put forward for future development of foreign‐body response resisting materials and current challenges that require in‐depth study.

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A review of implantable biosensors for closed-loop glucose control and other drug delivery applications

Cited by 74 publications

References 177 publications

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Design of a Sandwich Hierarchically Porous Membrane with Oxygen Supplement Function for Implantable Glucose Sensor

Titanium as an Instant Adhesive for Biological Soft Tissue

Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials

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