A review of halogenated natural products in Arctic, Subarctic and Nordic ecosystems

Bidleman, Terry F.; Andersson, Agneta; Jantunen, Liisa M.; Kucklick, John R.; Kylin, Henrik; Letcher, Robert J.; Tysklind, Mats; Wong, Fiona

doi:10.1016/j.emcon.2019.02.007

Cited by 43 publications

(37 citation statements)

References 240 publications

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“…Several aspects of Cl have been summarised previously, e.g., physiological roles (White and Broadley 2001 ; Yunos et al 2010 ), and the POP perspectives (Winterton 2000 ; Bidleman et al 2019 ) and will not be the primary focus here. Rather, this review represents an update and supplement to previous reviews focusing on the terrestrial Cl cycling (Clarke et al 2009 ; Graedel and Keene 1996 ; Öberg 2002 ; Leri and Myneni 2010 ; Öberg and Bastviken 2012 ; Vodyanitskii and Makarov 2017 ) called upon by the emerging interest in the behaviour of 36 Cl in soils and terrestrial ecosystems (Limer et al 2009 ; Sheppard et al 1996 ; van den Hoof and Thiry 2012 ; Le Dizès and Gonze 2019 ; Tanaka and Thiry 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Chlorine cycling and the fate of Cl in terrestrial environments

Svensson

Kylin

Montelius

et al. 2021

Environ Sci Pollut Res

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Chlorine (Cl) in the terrestrial environment is of interest from multiple perspectives, including the use of chloride as a tracer for water flow and contaminant transport, organochlorine pollutants, Cl cycling, radioactive waste (radioecology; 36Cl is of large concern) and plant science (Cl as essential element for living plants). During the past decades, there has been a rapid development towards improved understanding of the terrestrial Cl cycle. There is a ubiquitous and extensive natural chlorination of organic matter in terrestrial ecosystems where naturally formed chlorinated organic compounds (Clorg) in soil frequently exceed the abundance of chloride. Chloride dominates import and export from terrestrial ecosystems while soil Clorg and biomass Cl can dominate the standing stock Cl. This has important implications for Cl transport, as chloride will enter the Cl pools resulting in prolonged residence times. Clearly, these pools must be considered separately in future monitoring programs addressing Cl cycling. Moreover, there are indications that (1) large amounts of Cl can accumulate in biomass, in some cases representing the main Cl pool; (2) emissions of volatile organic chlorines could be a significant export pathway of Cl and (3) that there is a production of Clorg in tissues of, e.g. plants and animals and that Cl can accumulate as, e.g. chlorinated fatty acids in organisms. Yet, data focusing on ecosystem perspectives and combined spatiotemporal variability regarding various Cl pools are still scarce, and the processes and ecological roles of the extensive biological Cl cycling are still poorly understood.

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Section: Introductionmentioning

confidence: 99%

Chlorine cycling and the fate of Cl in terrestrial environments

Svensson

Kylin

Montelius

et al. 2021

Environ Sci Pollut Res

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“…Simple bromophenols with all possible substitutions can be formed by photolysis of bromodiphenyl ethers. The meta -substituted bromophenols distinguish this process from natural formation, which produces exclusively ortho - and para -substituted bromophenols (Bidleman et al 2019 ). Compounds 41 and 42 were isolated from Dysidea sp.…”

Section: Discussionmentioning

confidence: 99%

Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges

Panggabean

Adiguna

Murniasih³

et al. 2022

Rev. Bras. Farmacogn.

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Graphical abstract Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity. This review remarks the attempt to provide a preliminary guidance from the perspective of structure–activity relationship and its participation on marine natural products research. This guidance is segregated by the compound’s classes and their cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity. Structure–activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended to narrow down the endless possibilities of cytotoxicity by giving a predictable structure–activity relationship for active compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure–activity relationship with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge.

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“…Oxidized halogen species then react with organic substrates within the species or with dissolved organic matter. [213][214][215][216][217][218] Two subclasses of HNPs exist:…”

Section: G Climate Change and Emerging Contaminant Issuesmentioning

confidence: 99%