Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges

Abstract

Graphical abstract Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity. This review remarks the attempt to provide a preliminary guidance from the perspective of structure–activity relationship and its participation on marine natural products research. This guidance is segregated by the compound’s classes and their cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity. Structure–activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended to narrow down the endless possibilities of cytotoxicity by giving a predictable structure–activity relationship for active compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure–activity relationship with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge.

PTP1B Inhibitors from Indonesian Plants and Its Structure-Activity Relationship: A Review

“…Furthermore, the other compounds with variations of the C-3 moiety, angeloyloxy (23 and 27), tigloyloxy (24 and 28), and hydroxyl (30), displayed less PTP1B inhibition, indicating the cinnamoyloxy group, as seen in 21 and 25, is more favorable for this activity. In addition, PTP1B activity is more prone to diterpenes with a 9-H framework (21-24) than 9-unsaturated bond analogs (29 and 30), a secondary alcohol (31), a lactone (32), and 9-OH analogs (25)(26)(27)(28).…”

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Marine Natural Products with Activities against Prostate Cancer: Recent Discoveries

“…In 2019, the cytotoxic activity of four ceylonamide compounds, ceylonamide F, G, H and I, isolated from the Indonesian marine sponge Sponia sp. were evaluated in DU145 cells in 2-dimensional (2D) cell cultures [ 97 , 98 ]. Two of these compounds, ceylonamide G and F, showed inhibition of DU145 cell growth in 2D cultures, with an IC50 of 6.9 µM and 18.8 µM, respectively.…”

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

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