As the high value and the scarcity of large-flake graphite ore resources, it is in the best interest to maximize the amount of large flakes and minimize any processing that will reduce flake sizes. In the study, the mineralogy of an African graphite ore was estimated using X-ray diffraction (XRD), X-ray fluorescence (XRF), and optical microscope analyses. The results indicated that it was a heavily weathered large flake graphite ore and the main gangue minerals were quartz and kaolinite. The graphite flakes were thick, bent, and fractured, and some clay minerals were embedded into the graphite interlayer, which made it difficult to prevent the large flakes from being destroyed using mechanical grinding methods. An approach of steel rod coarse grinding and pebble regrinding effectively reduced the destruction of graphite flakes and improved the grinding efficiency. In addition, comparing with the conventional process, a pre-screening process was applied and the content of large flakes in the final concentrate was significantly improved.