A Review of Glymphatics and the Impact of Osteopathic Manipulative Treatment in Alzheimer's Disease, Concussions, and Beyond

Marino, Maxwell A; Petrova, Sarah; Sweiss, Raed; Duong, Jason; Miulli, Dan E

doi:10.7759/cureus.23620

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…Additionally, our institution incorporates osteopathic manipulative treatment, which has been shown to decrease ICP [ 20 ] ( Table 1 ). In Marino, et al [ 21 ], the authors review the connection between cerebral concussion, brain edema, and other diseases and how the glymphatic’s neurophysiology changes with different conditions. The glymphatic flow and drainage can be enhanced with treatments that affect the peri-arterial CSF influx route, the perivenous efflux route, and the transparenchymal route.…”

Section: Current Treatment and Management Strategies In Tbimentioning

confidence: 99%

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury

Patchana¹,

Agrawal²,

Connett³

et al. 2023

J Biotechnol Biomed

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A review was performed utilizing PubMed and GoogleScholar to highlight the future directions of EMF research in the setting of brain pathology, specifically in ischemic and traumatic brain injury. Additionally, a critical review of the current state-of-the art of EMF use in treating brain pathology has been conducted. The authors have added to this large body of research their own experimental studies, including a description of the on-going studies. The field of EMF utilization in the diagnosis and treatment of brain injury is highly promising and warrant careful studies in clinically relevant experimental models followed by human trials in TBI.

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Section: Current Treatment and Management Strategies In Tbimentioning

confidence: 99%

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury

Patchana¹,

Agrawal²,

Connett³

et al. 2023

J Biotechnol Biomed

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“…Aquaporin-related channels control brain fluid flow, removing metabolites, oedema, and waste. However, this fluid accumulates during illness, whether as a result of structural abnormalities, aquaporin channel downregulation, the accumulation of toxic compounds, or the body's inability to properly discharge the interstitium [ 39 ].…”

Section: Reviewmentioning

confidence: 99%

Alzheimer’s Disease: Understanding Its Novel Drug Delivery Systems and Treatments

Dhingra¹,

Choudhari²

2022

Cureus

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Around the world, there are no fewer than 24 million people who suffer from dementia. Through 2040, this number is expected to rise steadily every 20 years. Alzheimer's disease (AD), the most prevalent kind of dementia, is characterised by a steady deterioration in cognitive function that most often begins with memory loss. Alzheimer's disease (AD) is considered to be one of the leading causes of morbidity in the elderly. Around 5 million people in the United States have Alzheimer's disease. Still, because AD is common in the older and greying population, its prevalence is expected to rise dramatically in the coming decades. As the disease progresses, people with Alzheimer's disease frequently become dependent on caregivers. The Alzheimer's-diseased brain is characterised neuropathologically by diffuse and neuritic extracellular amyloid plaques, which are often ringed by dystrophic neurites and intracellular neurofibrillary tangles. This particular disease is characterised by the presence of reactive microgliosis and the destruction of neurons, white matter, and synapses. The present review is done to study and learn about new treatments and novel drug delivery systems that may provide benefits to patients with AD. With the new drugs, treatments, constant care requirements, and lost productivity, Alzheimer's has a substantial financial impact on society. Therefore, better management and therapy are crucial. In this overview, we will briefly go through the current knowledge base about AD, covering the functions of beta-amyloid, tau proteins, and stem cell therapy, and elaborating on novel diagnostic and therapeutic interventions.

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“…However, a literature search related to applications of osteopathic medicine, specifically in neurosurgical patient populations, yields relatively few results. In a search of PubMed at the time of this study's submission, 10,730 articles contained keywords related to osteopathic medicine, but of these, only 14 were research related to the care of patients with conditions typically requiring neurosurgical consultation [13][14][15][16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Craniosacral therapy has been shown to alleviate symptoms in individuals who have suffered a concussion [40][41][42] and in individuals with normal pressure hydrocephalus [17]. The glymphatic systemthe lymphatic drainage system of the CNS -is shown to be modifiable with cranial osteopathic manipulative techniques as well as Dalrymple and thoracic pump techniques in the setting of traumatic brain injury [13,15].…”

Section: Introductionmentioning

confidence: 99%

A Survey Assessment of Neurosurgeons’ Interest in Osteopathic Medicine and Its Integration Into Their Practice

Kolmetzky,

Gooder,

Polly

et al. 2024

Cureus

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Introduction: Osteopathic manipulative medicine (OMM) encompasses techniques guided by the tenets of osteopathy aimed at facilitating the body's natural self-healing capabilities as a treatment option for injury or illness. This approach recognizes the interrelationship of structure and function in promoting overall health. The clinical applications of OMM have been highly researched throughout different subspecialties of medicine; however, there is a notable lack of osteopathic-based research targeted toward neurosurgical patient populations.Methods: This cross-sectional descriptive study was conducted via a survey generated using SurveyMonkey (SurveyMonkey, San Mateo, CA, USA; accessed at www.surveymonkey.com). Subjects for this survey were gathered using a convenience sampling method in which emails of all neurosurgeons listed in the "Member Directory" on the American Association of Neurological Surgeons website were compiled into a mailing list. The survey was sent to all 6,503 emails collected, and the responses were recorded over the next month. The responses for each survey question were averaged and, when appropriate, compared using a two-tailed Ttest, with statistical significance defined as a p<0.05. Where applicable, simple linear regression analysis was used to assess correlations between survey data. The measured outcomes included neurosurgeons' (1) knowledge of and (2) attitudes toward OMM.Results: Both MD and DO neurosurgeons reported using OMM (or referring their patients for OMM) less than once per year. In comparison to their MD colleagues, neurosurgeons carrying a DO degree ranked their familiarity with the tenets of osteopathic medicine (p<0.0001) and their knowledge of the applications of OMM in their practice (p=0.0018) significantly higher. Greater reported familiarity with the tenets of osteopathic medicine and applications of OMM showed a positive correlation with neurosurgeons' comfort in recommending OMM as a nonsurgical, preoperative treatment option, as a post-surgical, rehabilitative treatment option, and as a pain management option (p<0.0001 for all). There was a clear interest in seeing further osteopathic-based neurosurgery research by both MD and DO neurosurgeons, as well as a trend of interest in incorporating OMM into their practice if shown to be clinically beneficial.Conclusions: Both MD and DO neurosurgeons are interested in seeing more research into the applications of OMM in their patient populations and, most importantly, are likely to integrate OMM into their practice if presented with research detailing clinical benefits to their patients. This study highlights the clinical interest of neurosurgeons in further research into the applications of OMM specific to the field of neurosurgery.

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A Review of Glymphatics and the Impact of Osteopathic Manipulative Treatment in Alzheimer's Disease, Concussions, and Beyond

Cited by 3 publications

References 30 publications

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury

Alzheimer’s Disease: Understanding Its Novel Drug Delivery Systems and Treatments

A Survey Assessment of Neurosurgeons’ Interest in Osteopathic Medicine and Its Integration Into Their Practice

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