A Review of Glycated Albumin as an Intermediate Glycation Index for Controlling Diabetes

Roohk, H. Vernon; Zaidi, Asad R.

doi:10.1177/193229680800200620

Cited by 158 publications

(129 citation statements)

References 42 publications

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“…The result of a survey of endocrinologists provides an assessment of the degree of utility and acceptance of GA as a new monthly management tool for diabetes23.…”

Section: Discussionmentioning

confidence: 99%

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Wang²,

Tao

et al. 2015

J of Diabetes Invest

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Aims/IntroductionTo assess glycated albumin (GA) as a potential glycemic index in managing gestational diabetes mellitus (GDM).Materials and MethodsEligible pregnant women were divided into the GDM group with abnormal result on a 75‐g oral glucose tolerance test (OGTT) and the control (normal) group. GA measurements, Pearson's correlation analysis, multiple logistic regression and receiver operating characteristic curve analysis were obtained at the follow‐up examination of participants in the two groups.ResultsA total of 2,118 women were assigned to the GDM group (n = 639) and control group (n = 1,479). The mean level of serum GA in GDM group was significantly greater than that in the control group at both 24–28 and 36–38 weeks of gestation (P < 0.05). The area under the receiver operating characteristic curve for GA defining good glycemic control in GDM was 0.874 (95% confidence interval 0.811–0.938). The cut‐off point for the GA levels derived from the receiver operating characteristic curve was 11.60%, which had sensitivity and specificity for detecting a poor glycemic status of 75.93% and 86.36%, respectively. The risk of birthweight ≥3,500 g and macrosomia increased significantly with GA levels ≥13.00% at 24–28 weeks and ≥12.00% at 36–38 weeks of gestation.ConclusionsGA might be an appropriate and conveniently measured index that can detect poor glycemic control and predict birthweights in GDM women.

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“…The result of a survey of endocrinologists provides an assessment of the degree of utility and acceptance of GA as a new monthly management tool for diabetes23.…”

Section: Discussionmentioning

confidence: 99%

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Wang²,

Tao

et al. 2015

J of Diabetes Invest

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“…An early product of the glycation process is an Nlinked fructosamine adduct [11]. This fructosamine-protein adduct has a 1,2 cis-diol which can form covalent ester bonds with boronic acids (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

“…A rapid test for gHSA as a monthly indicator of glycation could bring about a substantial healthcare cost savings as well as an increase in patient compliance [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors

Stefansson¹,

Stefansson²,

Chung³

et al. 2012

Journal of Nanotechnology

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Biomolecular detections performed on carbon nanotube field-effect transistors (CNT-FETs) frequently use reactive pyrenes as an anchor to tether bioactive ligands to the hydrophobic nanotubes. In this paper, we explore the possibility of directly using bioactive aromatic compounds themselves as CNT-FET ligands. This would be an efficient way to functionalize CNT-FETs since many aromatic compounds bind avidly to nanotubes, and it would also ensure that ligand-binding molecules would be brought in close proximity to the nanotubes. Using a model system consisting of pyrene, phenanthrene, naphthalene, or phenyl boronic acids immobilized on CNT-FET wafers, we show that all are able to bind glycated human serum albumin (gHSA), which is an important diabetes marker. Pyrene boronic acid proved to bind CNTs with the greatest apparent affinity as measured by gHSA impedance. Interestingly, gHSA CNT-FET signal intensity, which is proportional to amount of protein bound, remained essentially unchanged for all the boronic acids tested.

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“…However, this test presents low accuracy since it is influenced by all plasma proteins and also by other molecules present in the blood, such as bilirubin, uric acid and low molecular weight substances (12). Further, fructosamine is not available at all laboratories (18,29) and there are no well-established international standards for its use.…”

Section: Laboratory Measurement Of Gamentioning

confidence: 99%

Glycated albumin: a potential biomarker in diabetes

Freitas

Ehlert

Camargo

2017

Arch. Endocrinol. Metab.

138

103

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Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform. These laboratory characteristics have ensured the highlight of GA in studies from the last decade, as a marker of monitoring and screening for DM, as well as a predictor of long-term outcomes of the disease. The aim of this review was to discuss the physiological and biochemistry characteristics of the GA, as well as its clinical utility in DM. Arch Endocrinol Metab.2017;61(3):296-304.

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A Review of Glycated Albumin as an Intermediate Glycation Index for Controlling Diabetes

Cited by 158 publications

References 42 publications

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Association between glycemic control and birthweight with glycated albumin in Chinese women with gestational diabetes mellitus

Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors

Glycated albumin: a potential biomarker in diabetes

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