A review of drug release mechanisms from nanocarrier systems

Ding, Chizhu; Liu, Yupeng

doi:10.1016/j.msec.2017.03.130

Cited by 202 publications

(122 citation statements)

References 110 publications

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“…Similar to how a fibrotic capsule forms over implants to isolate it, these coatings, however, achieve this through a highly controlled method without undesirable consequences . One common material used in coatings is poly(ethylene glycol) (PEG), a biocompatible polymer well‐known for its low protein‐adsorbing properties, which can be used to prevent a foreign body response, Hydrogel coatings can also be used over surfaces for enhanced biocompatibility, while still permitting chemical sensing or drug delivery functions to occur due to their permeability. Coatings can further provide mechanical reinforcement to components that may be exposed to mechanical stresses within the body …”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment

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Liu

Owh

et al. 2019

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Artificial skin devices are able to mimic the flexibility and sensory perception abilities of the skin. They have thus garnered attention in the biomedical field as potential skin replacements. This Review delves into issues pertaining to these skin‐deep devices. It first elaborates on the roles that these devices have to fulfill as skin replacements, and identify strategies that are used to achieve such functionality. Following which, a comparison is done between the current state of these skin‐deep devices and that of natural skin. Finally, an outlook on artificial skin devices is presented, which discusses how complementary technologies can create skin enhancements, and what challenges face such devices.

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Section: Challenges and Perspectivesmentioning

confidence: 99%

Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment

Low

Liu

Owh

et al. 2019

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“…These approaches not only increase drug bioavailability and capacity to cross physical barriers, but also reduce the dosage to be used for treatment, consequently reducing the toxic side effects of the delivered drugs [33,34]. As shown in Figure 1, current methods for controlled drug delivery mainly include exogenous stimuli-responsive, endogenous stimuli-responsive, and multi-stimuli-responsive drug delivery.…”

Section: Ways Of Controlled Drug Deliverymentioning

confidence: 99%

Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery

2017

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Abstract:Graphene-based nanomaterials have exhibited wide applications in nanotechnology, materials science, analytical science, and biomedical engineering due to their unique physical and chemical properties. In particular, graphene has been an excellent nanocarrier for drug delivery application because of its two-dimensional structure, large surface area, high stability, good biocompatibility, and easy surface modification. In this review, we present the recent advances in the synthesis and drug delivery application of graphene-based nanomaterials. The modification of graphene and the conjugation of graphene with other materials, such as small molecules, nanoparticles, polymers, and biomacromolecules as functional nanohybrids are introduced. In addition, the controlled drug delivery with the fabricated graphene-based nanomaterials are demonstrated in detail. It is expected that this review will guide the chemical modification of graphene for designing novel functional nanohybrids. It will also promote the potential applications of graphene-based nanomaterials in other biomedical fields, like biosensing and tissue engineering.

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“…Oral drug delivery is the most widely used and most readily accepted form of drug administration as it is simple, painless and selfadministered [36,37]. It is the most convenient and safe administration route, particularly for chronic delivery, but it poses a number of challenges for the formulator in terms of bioavailability (fraction of drug actually reaching the circulation) due to degradation by enzymes and harsh pH conditions, low solubility of some drugs or limited absorption by the GIT epithelium [38].…”

Section: Challenges Of In Vivo Researchmentioning

confidence: 99%

In vivo Studies for Drug Development via Oral Delivery: Challenges, Animal Models and Techniques

Brake¹,

Gumireddy²,

Tiwari³

et al. 2017

Pharm Anal Acta

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Drug discovery and development involves a complex iterative process of new molecules synthesis, formulations, and in vitro analysis, followed by biochemical and cellular assays, with final validation in animal models, and ultimately in humans. The purpose of this article is to present a concise overview of the rationale and challenges for performing in vivo studies, the types of animal models, and modern in vivo research techniques for oral drug delivery.

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A review of drug release mechanisms from nanocarrier systems

Cited by 202 publications

References 110 publications

Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment

Using Artificial Skin Devices as Skin Replacements: Insights into Superficial Treatment

Recent Advances in the Synthesis of Graphene-Based Nanomaterials for Controlled Drug Delivery

In vivo Studies for Drug Development via Oral Delivery: Challenges, Animal Models and Techniques

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