A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Guan, Ruirui; Le, Quyet Van; Han, Yang‐Su; Zhang, Dangquan; Gu, Haiping; Yang, Yafeng; Sonne, Christian; Lam, Su Shiung; Zhong, Jiateng; Zhu, Jinyan; Liu, Runqiang; Peng, Wanxi

doi:10.1016/j.chemosphere.2020.129499

Cited by 91 publications

(65 citation statements)

References 230 publications

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“…Importantly, it has been determined that Alzheimer's drug memantine triggered bcl 2-like protein (Bax) 4-dependent pathway of apoptosis in 4T1 breast cancer cells and inhibited p-ERK protein expression in a time dependent manner [125]. Additionally, the considerable efforts have been made to conceptualize the dietary phytochemicals and their relation to oxidative stress and human diseases [126]. This recently published résumé revealed that a functional diet rich in polyphenols, fatty acids, alkaloids, and lycopene is helpful to alleviate neurological and cognitive diseases and a broad number of phytochemicals delay the spread and growth of cancer cells as well [126].…”

Section: Spirochaetesmentioning

confidence: 99%

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

et al. 2021

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The negative association between Alzheimer’s disease (AD) and cancer suggests that susceptibility to one disease may protect against the other. When biological mechanisms of AD and cancer and relationship between them are understood, the unsolved problem of both diseases which still touches the growing human population could be overcome. Actual information about biological mechanisms and common risk factors such as chronic inflammation, age-related metabolic deregulation, and family history is presented here. Common signaling pathways, e.g., p53, Wnt, role of Pin1, and microRNA, are discussed as well. Much attention is also paid to the potential impact of chronic viral, bacterial, and fungal infections that are responsible for the inflammatory pathway in AD and also play a key role to cancer development. New data about common mechanisms in etiopathology of cancer and neurological diseases suggests new therapeutic strategies. Among them, the use of nilotinib, tyrosine kinase inhibitor, protein kinase C, and bexarotene is the most promising.

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Section: Spirochaetesmentioning

confidence: 99%

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

et al. 2021

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“…Antioxidants are molecules capable of slowing down, counteracting, or neutralizing the action of free radicals, thus protecting the body from oxidative stress and related diseases [ 1 ]. A variety of processes in the body (e.g., food digestion, hepatic drug metabolism, exposure to UV rays, cigarette smoke, and environmental pollutants) can produce free radicals, mostly reactive oxygen species (ROS) that include both oxygen radicals, such as superoxide anion (O 2 •– ), hydroxyl ( • OH), peroxyl (ROO • ), and alkoxyl (RO • ) radicals, as well as non-radical species that are oxidizing agents or can be easily converted into radicals, such as hypochlorous acid (HOCl), peroxynitrite (ONOO – ), singlet oxygen ( 1 O 2 ), and hydrogen peroxide (H 2 O 2 ).…”

Section: Introductionmentioning

confidence: 99%

A Smartphone-Based Chemosensor to Evaluate Antioxidants in Agri-Food Matrices by In Situ AuNP Formation

Calabria

Guardigli

Severi

et al. 2021

Sensors

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In recent years, there has been a continuously growing interest in antioxidants by both customers and food industry. The beneficial health effects of antioxidants led to their widespread use in fortified functional foods, as dietary supplements and as preservatives. A variety of analytical methods are available to evaluate the total antioxidant capacity (TAC) of food extracts and beverages. However, most of them are expensive, time-consuming, and require laboratory instrumentation. Therefore, simple, cheap, and fast portable sensors for point-of-need measurement of antioxidants in food samples are needed. Here, we describe a smartphone-based chemosensor for on-site assessment of TAC of aqueous matrices, relying on the antioxidant-induced formation of gold nanoparticles. The reaction takes place in ready-to-use analytical cartridges containing an hydrogel reaction medium preloaded with Au(III) and is monitored by using the smartphone’s CMOS camera. An analytical device including an LED-based lighting system was developed to ensure uniform and reproducible illumination of the analytical cartridge. The chemosensor permitted rapid TAC measurements of aqueous samples, including teas, herbal infusions, beverages, and extra virgin olive oil extracts, providing results that correlated with those of the reference methods for TAC assessment, e.g., oxygen radical absorbance capacity (ORAC).

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“…Nowadays, phenolic compounds are at the center of attention, as they play a crucial role in preventing oxidation processes and have highly valued functions in improving health and preventing disturbances ranging from cancer, inflammation, high blood pressure, neurodegenerative disorders, and obesity to skin disorders and acute oxidative damage, etc. [ 4 , 5 ]. Therefore, besides halophytes, phenolic extracts hold great importance, due to their variety of applications in fields such as the food industry, cosmetics, pharmaceuticals and medicine [ 2 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…[ 4 , 5 ]. Therefore, besides halophytes, phenolic extracts hold great importance, due to their variety of applications in fields such as the food industry, cosmetics, pharmaceuticals and medicine [ 2 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum

et al. 2021

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This work aimed to evaluate the phenolic content and in vitro antioxidant, antimicrobial and enzyme inhibitory activities of the methanol extracts and their fractions of two edible halophytic Limonium species, L. effusum (LE) and L. sinuatum (LS). The total phenolic content resulted about two-fold higher in the ethyl acetate fraction of LE (522.82 ± 5.67 mg GAE/g extract) than in that of LS (274.87 ± 1.87 mg GAE/g extract). LC-MS/MS analysis indicated that tannic acid was the most abundant phenolic acid in both species (71,439.56 ± 3643.3 µg/g extract in LE and 105,453.5 ± 5328.1 µg/g extract in LS), whereas hyperoside was the most abundant flavonoid (14,006.90 ± 686.1 µg/g extract in LE and 1708.51 ± 83.6 µg/g extract in LS). The antioxidant capacity was evaluated by DPPH and TAC assays, and the stronger antioxidant activity in ethyl acetate fractions was highlighted. Both species were more active against Gram-positive bacteria than Gram negatives and showed considerable growth inhibitions against tested fungi. Interestingly, selective acetylcholinesterase (AChE) activity was observed with LE and LS. Particularly, the water fraction of LS strongly inhibited AChE (IC50 = 0.199 ± 0.009 µg/mL). The ethyl acetate fractions of LE and LS, as well as the n-hexane fraction of LE, exhibited significant antityrosinase activity (IC50 = 245.56 ± 3.6, 295.18 ± 10.57 and 148.27 ± 3.33 µg/mL, respectively). The ethyl acetate fraction and methanol extract of LS also significantly inhibited pancreatic lipase (IC50 = 83.76 ± 4.19 and 162.2 ± 7.29 µg/mL, respectively). Taken together, these findings warrant further investigations to assess the potential of LE and LS as a bioactive source that can be exploited in pharmaceutical, cosmetics and food industries.

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A review of dietary phytochemicals and their relation to oxidative stress and human diseases

Cited by 91 publications

References 230 publications

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

A Smartphone-Based Chemosensor to Evaluate Antioxidants in Agri-Food Matrices by In Situ AuNP Formation

Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum

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