A review of current advances in the detection of organophosphorus chemical warfare agents based biosensor approaches

Diauudin, Farah Nabila; Rashid, Jahwarhar Izuan Abdul; Knight, Victor Feizal; Yunus, Wan Md Zin Wan; Ong, Keat Khim; Kasim, Noor Azilah Mohd; Halim, Norhana Abdul; Noor, Siti Aminah Mohd

doi:10.1016/j.sbsr.2019.100305

Cited by 59 publications

(39 citation statements)

References 97 publications

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“…However, organophosphates have a long half-life and accumulate in the environment for a certain period of time. Other types of organophosphates can act as nerve agents, which are used in chemical warfare, or enter into the river and groundwater cycle from the waste of industrial products, such as plastics, lubricants, refrigerants, fuels, solvents, dispersants, and surfactants [ 7 , 257 ]. The chemical structure of these compounds falls into the two following groups: oxon (P=O) and thion (P=S) [ 258 ].…”

Section: Application Of Paper Biosensors In the Detection Of Toxic Materialsmentioning

confidence: 99%

Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review

Bordbar

Sheini

Hashemi³

et al. 2021

Biosensors

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The fast detection of trace amounts of hazardous contaminations can prevent serious damage to the environment. Paper-based sensors offer a new perspective on the world of analytical methods, overcoming previous limitations by fabricating a simple device with valuable benefits such as flexibility, biocompatibility, disposability, biodegradability, easy operation, large surface-to-volume ratio, and cost-effectiveness. Depending on the performance type, the device can be used to analyze the analyte in the liquid or vapor phase. For liquid samples, various structures (including a dipstick, as well as microfluidic and lateral flow) have been constructed. Paper-based 3D sensors are prepared by gluing and folding different layers of a piece of paper, being more user-friendly, due to the combination of several preparation methods, the integration of different sensor elements, and the connection between two methods of detection in a small set. Paper sensors can be used in chromatographic, electrochemical, and colorimetric processes, depending on the type of transducer. Additionally, in recent years, the applicability of these sensors has been investigated in various applications, such as food and water quality, environmental monitoring, disease diagnosis, and medical sciences. Here, we review the development (from 2010 to 2021) of paper methods in the field of the detection and determination of toxic substances.

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Section: Application Of Paper Biosensors In the Detection Of Toxic Materialsmentioning

confidence: 99%

Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review

Bordbar

Sheini

Hashemi³

et al. 2021

Biosensors

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show abstract

“…surface-enhanced Raman scattering (SERS)-based sensors, that recognize the target analytes utilizing the electromagnetic field enhancement of plasmonic substrates in combination with the chemical specificity of vibrational Raman spectroscopy; [69] iv) supramolecular sensors, involving the occurrence of non-covalent interactions between the sensing system and the analyte; [8] v) biosensors, in which the biological recognition component should be immobilized and have intimate contact with the transducer upon binding with the analyte, yielding ultimately qualitative and quantitative responses; [85] vi) liquid crystal-based sensors, that, upon contact with the analyte, yield orientational (and thus optical) responses; [86] vii) colorimetric and fluorescence sensors, more investigated than the previously mentioned ones, enabling gas detection through the measurement of color/luminescence variations. [4,9,12,[15][16][17]23,25,59,87] In this broad context, chemoresistive gas sensors based on nanostructured semiconducting oxides yield various important advantages, encompassing moderate processing costs, compatibility with silicon technology, miniaturization possibility, simple operation, and high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Metal Oxide Nanosystems As Chemoresistive Gas Sensors for Chemical Warfare Agents: A Focused Review

Barreca

Maccato

Gasparotto

2022

Adv Materials Inter

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The early and efficient detection of chemical warfare agents (CWAs), hazardous compounds resulting in fatal and irreversible health damages, is an issue of primary importance for security safeguard. Despite the efforts undertaken to date, the quest of lower detection limits, higher selectivity/stability, and faster recognition still represents a main bottleneck to effectively counteract such dreadful threats. This review aims at providing a survey on the developments undertaken in chemoresistive gas sensors based on metal oxide nanosystems for CWA recognition. The sensing mechanisms proposed in the literature, as well as the main reasons underlying the performance enhancement for functionalized/composite systems, are reviewed and discussed. The work summarizes key results achieved so far, and attempts to provide guidelines to overcome the main open problems. Efforts are devoted to delivering information on material properties/performance interplay, highlighting challenges in their fabrication and functional characterization. In fact, despite the advances made, a rational design and understanding of interfacial properties, as well as a perfect control over system growth, mandatory for commercial applications, are still missing. At the conclusion, a brief outlook on development prospects for future advancements is presented, endeavoring to provide a vision on the next necessary steps for an eventual technological implementation.

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“…1 OPs are highly neurotoxic synthetic compounds 5 that inhibit cholinesterase and regulate acetylcholine needed for the functioning of the nervous system. 6,7 It is important to detect the presence of Ac even at low levels. In line with this matter, numerous detection techniques have been developed for the determination of Ops, including Ac.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of a gold nanoparticle-based aptasensor integrated with image processing for the colorimetric detection of acephate using response surface methodology

et al. 2021

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A review of current advances in the detection of organophosphorus chemical warfare agents based biosensor approaches

Cited by 59 publications

References 97 publications

Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review

Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review

Metal Oxide Nanosystems As Chemoresistive Gas Sensors for Chemical Warfare Agents: A Focused Review

Optimisation of a gold nanoparticle-based aptasensor integrated with image processing for the colorimetric detection of acephate using response surface methodology

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