A Review of Clinical Translation of Inorganic Nanoparticles

Anselmo, Aaron C.; Mitragotri, Samir

doi:10.1208/s12248-015-9780-2

Cited by 414 publications

(328 citation statements)

References 101 publications

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“…Moreover, many inorganic compounds serving as the material for making NPs have been widely used in clinical practice for several therapeutic applications. 174 One example of therapeutic compounds that act as antibacterial agents is silver ions. [175][176][177] Inorganic NPs offer diagnostic and therapeutic opportunity that other PNPs or not, cannot offer.…”

Section: Polymeric Npsmentioning

confidence: 99%

See 1 more Smart Citation

Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?

Voltan¹,

Quindós²,

Alarcón³

et al. 2016

IJN

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Invasive mycoses are a major problem for immunocompromised individuals and patients in intensive care units. Morbidity and mortality rates of these infections are high because of late diagnosis and delayed treatment. Moreover, the number of available antifungal agents is low, and there are problems with toxicity and resistance. Alternatives for treating invasive fungal infections are necessary. Nanostructured systems could be excellent carriers for antifungal drugs, reducing toxicity and targeting their action. The use of nanostructured systems for antifungal therapy began in the 1990s, with the appearance of lipid formulations of amphotericin B. This review encompasses different antifungal drug delivery systems, such as liposomes, carriers based on solid lipids and nanostructure lipids, polymeric nanoparticles, dendrimers, and others. All these delivery systems have advantages and disadvantages. Main advantages are the improvement in the antifungal properties, such as bioavailability, reduction in toxicity, and target tissue, which facilitates innovative therapeutic techniques. Conversely, a major disadvantage is the high cost of production. In the near future, the use of nanosystems for drug delivery strategies can be used for delivering peptides, including mucoadhesive systems for the treatment of oral and vaginal candidiasis.

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Section: Polymeric Npsmentioning

confidence: 99%

“…[175][176][177] Inorganic NPs offer diagnostic and therapeutic opportunity that other PNPs or not, cannot offer. 174 PNPs have some problems arising from residues of organic solvents used in the production process, such as …”

Section: Polymeric Npsmentioning

confidence: 99%

Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?

Voltan¹,

Quindós²,

Alarcón³

et al. 2016

IJN

View full text Add to dashboard Cite

show abstract

“…These findings emphasize the need to reconsider strategies for the improvement of NPs, including potential patient selection to identify those most likely to respond to nano-medicines. Nanotechnology-enabled diagnostic and therapeutics based on dendrimers [50][51], gold [52][53], silica [54][55], iron oxide [53,[56][57] and hafnium oxide [58][59] are also currently under clinical analysis, with the majority intended for oncological applications. For example gold NPs decorated with a surface of PEG conjugated to TNFα molecules are in phase I/II trials for solid tumour therapy [60].…”

Section: Major Diseases Leading To Kidney Failurementioning

confidence: 99%

A mini review highlights on the application of nano-materials for Kidney disease: A key development in Medicinal therapy

Rahman¹,

Likius²,

Uahengo³

et al. 2017

Nephrol Renal Dis

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Nanoparticles have been one of the emerging tools in medical field as a technology well-suited for the diagnosis and treatment of various diseases. They have been heralded as efficacious owing to both in terms of improved therapeutic efficacy as well as reduction of treatment side effects in some cases. Various nanomaterials have been developed which can be tagged with targeting moieties, and with drug delivery and imaging capability or combination of both as theranostic agent.Biotechnology to a large extent relies greatly on biomolecules such as proteins and DNA. Research in the field of bio technology will undeniably profit with the initiation of chemical and materials synthesis (e.g. multifunctional nanoparticle systems) that allows fusion of these biomolecules to nanostructured inorganic and organic materials. These nanomaterials have been thoroughly investigated for treatment and detection of various pathological conditions. This mini review highlights, the shape, size of nanoparticles to demonstrate the current research and applications of nanoparticles in the treatment of kidney diseases.

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“…We also describe photonic devices that use these functional elements. Fluorescent probes, single plasmonic nanoparticles, and light-activated drugs are reviewed elsewhere [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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A Review of Clinical Translation of Inorganic Nanoparticles

Cited by 414 publications

References 101 publications

Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?

Fungal diseases: could nanostructured drug delivery systems be a novel paradigm for therapy?

A mini review highlights on the application of nano-materials for Kidney disease: A key development in Medicinal therapy

Toward biomaterial-based implantable photonic devices

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