A Review of Chinese Raman Spectroscopy Research Over the Past Twenty Years

Wang, Jie; Liu, Kaiyuan; Jin, Shangzhong; Jiang, Li; Liang, Pei

doi:10.1177/0003702819828360

Cited by 6 publications

(3 citation statements)

References 208 publications

(210 reference statements)

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“…Raman spectroscopy is one of the most important spectroscopic techniques for structure analysis and identi cation, known as the " ngerprint" of molecular. Owing to its rapid and non-destructive testing advantages, Raman spectroscopy has been widely used in various elds (Wang et al 2019), such as biomedicine (Huang et However, the inconsistency in technical speci cations and evaluation methods has caused serious challenges in the production, marketing, and application of different Raman spectrometers with various models and application scenarios: (i) the lack of general testing procedures and overall evaluation bases in the design, production, and type selection of the spectrometers; (ii) the poor comparability of product speci cations, seriously affecting the order of the market; (iii) the application scopes of the products are unclear and nonspeci c, which brings inconvenience to the users in their purchase and application. Both users and manufacturers have a growing interest in the regulation of Raman spectrometers.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A strategy of product standardization and general performance evaluation for Raman spectrometers

Huang¹

2022

Preprint

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Raman spectroscopy has attracted more and more attention because of its advantages in rapid and non-destructive detection, as well as characteristic identification of molecular "fingerprint". It is now widely used in various fields such as food safety, biomedicine, material characterization, environmental science and judicial expertise. With rapid development of Raman technology, there are a variety of Raman spectrometers with different designs, properties, and applications. However, it is hard to assess the performance of different Raman spectrometers because of the lack of standardized testing and evaluation methods, which will severely hinder their production, sales and applications. In this paper current application status and configuration of Raman spectrometers are firstly reviewed, illustrating the urgent need of standardization in application and industrialization of Raman spectrometers. Then a novel overall testing procedure and evaluation method were developed so as to be adapted to a variety of Raman spectrometers. Five key specifications of Raman spectrometers were determined for performance evaluation. The entire testing procedure is economical, accessible, and environmentally friendly as using reusable solid materials and element lamps, as referenced. The validation results clearly illustrated the feasibility and applicability of the developed procedures and evaluation. Presented testing procedures and evaluation methods of Raman spectrometers provide a feasible strategy for the standardization of Raman spectrometers. The results of this study would be beneficial to instrumentation and technical exchanges for the development of Raman technology, which would definitely improve the application of Raman spectroscopy as an excellent analytical method.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: A strategy of product standardization and general performance evaluation for Raman spectrometers

Huang¹

2022

Preprint

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“…However, Raman-scattering signal is very weak, which has an intensity lower than (10 −6 ) that of the excitation. erefore, approaches for enhancing the Raman-scattering signals are always important for improving and realizing the related detection techniques [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Optical Feedback for Sensitivity Enhancement in Direct Raman Detection of Liquids

Liu

et al. 2021

Journal of Spectroscopy

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Detection of low-concentration molecules in liquids has been a challenge in sensing technologies. Raman spectroscopy is an effective approach for trace detection, which is in fact a “volume-excitation” and “volume-collection” technique in the analysis of liquid samples. However, for the commonly employed one-pass excitation and back-scattering detection scheme, a large portion of both the excitation laser energy and the Raman-scattering light energy is wasted without efficient reuse or collection. In this consideration, we demonstrate a broadband optical feedback scheme by a curved high-reflection mirror for both the excitation and the Raman-scattering light, so that the excitation and the forward-propagating Raman signal can be back-reflected and collected with a high efficiency. Using the “F+2f” design, where F and f are the focal lengths of the focusing lens and curved reflection mirror, respectively, we were able to not only produce two focuses of the excitation laser beam but also extend the Raman interaction by a doubled distance. For the detection of pure ethanol molecules and the R6G molecules in water with a concentration of 10−3 M, the Raman signal was enhanced by a factor of about 5.6. The optical feedback scheme and discovered optical mechanisms supply effective improvements to the Raman spectroscopic measurements on liquid samples.

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“…has unique fingerprinting information about its modes of vibration and rotation. [6,7] The advantages of conventional Raman spectroscopy detection using serum specimens are simplicity and convenience; simultaneously, no additional substrate preparation is required for conventional Raman spectroscopy, unlike surface-enhanced Raman spectroscopy. [8] Raman spectral analysis is based on peak intensities or peak position differences caused by changes in metabolites associated with diseases.…”

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confidence: 99%

Label‐free serum detection based on Raman spectroscopy for the diagnosis and classification of glioma

Zhang

Han²,

Sun

et al. 2020

J Raman Spectroscopy

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Glioma is the most prevalent malignant cancer in the central nervous system and can cause significant mortality and morbidity. A rapid, convenient, accurate, and relatively noninvasive diagnostic method for glioma is important and urgently needed. In this study, we investigated the feasibility of using Raman spectroscopy to discriminate patients with glioma from healthy individuals. Serum samples were collected from healthy individuals (n = 86) and patients with glioma [high-grade glioma (HGG) n = 75, low-grade glioma (LGG) n = 60]. All spectra were collected with a 785-nm wavelength laser in the range of 400-1800 cm −1. A total of three spectra were recorded for each sample, and every spectrum was integrated for 12 s and averaged over five accumulations. Principal component analysis and linear discriminant analysis models were combined to classify the Raman spectra of different groups. The correct classification ratios were 95.35, 93.33, and 93.34% for the normal, HGG, and LGG groups, respectively, and the total accuracy was 94.12%. The sensitivity, specificity, and accuracy of differentiating the HGG group from the normal group were 96.00, 96.51, and 96.27%, respectively, with an area under the curve of 0.997; in addition, the sensitivity, specificity, and accuracy of differentiating the LGG group from the normal group were 96.67%, 98.84%, and 97.95%, respectively, with an area under the curve of 0.999. Our study results suggested that the rapid and noninvasive detection method based on principal component analysis and linear discriminant analysis combined with Raman spectroscopy is a highly promising tool for the early diagnosis of glioma. K E Y W O R D S classification, diagnosis, glioma, Raman spectroscopy, serum 1 | BACKGROUND Brain tumors have become one of the top 10 malignant tumors that endanger the health of people as they age and with changes in environmental factors, and the incidence rate of these tumors is still on the rise. [1] Glioma, the most prevalent malignant cancer in the central nervous system, accounts for 40-50% of all intracranial Abbreviations: ANOVA, one-way analysis of variance; AUC, area under curve; HGG, high-grade glioma; LGG, low-grade glioma; PCA-LDA, principal component analysis and linear discriminant analysis; ROC, receive operating characteristic; WHO, World Health Organization.

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A Review of Chinese Raman Spectroscopy Research Over the Past Twenty Years

Cited by 6 publications

References 208 publications

WITHDRAWN: A strategy of product standardization and general performance evaluation for Raman spectrometers

WITHDRAWN: A strategy of product standardization and general performance evaluation for Raman spectrometers

Optical Feedback for Sensitivity Enhancement in Direct Raman Detection of Liquids

Label‐free serum detection based on Raman spectroscopy for the diagnosis and classification of glioma

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