A review of biological and pharmacological activities of Baccharis trimera

Rabêlo, Ana Carolina Silveira; Costa, Daniela Caldeira

doi:10.1016/j.cbi.2018.09.002

Cited by 32 publications

(13 citation statements)

References 81 publications

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“…The Baccharis genus, belonging to the Asteraceae family, comprises more than 500 species, distributed in the American continent and predominant in Argentina, Colombia, Chile, Mexico and Brazil [ 3 ]. This plant is popularly known as carqueja , and has several therapeutic purposes described in the literature, such as hepatoprotective [ 4 , 5 ], antiulcerogenic [ 6 ], anti-inflammatory [ 7 ], antioxidant and antiadipogenic properties [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice

et al. 2022

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The aim of this study is to evaluate the efficacy of Baccharis trimera infusion on high-fat diet-induced metabolic disorders in mice and macrophages activation. This study evaluated obesity, insulin resistance, dyslipidemia and hepatic steatosis induced by a high-fat diet in Swiss mice. Cellular parameters in macrophages, such as cell viability (MTT), the production and release of nitric oxide (NO) and hydrogen peroxide (H2O2), cell spreading, cell adhesion and phagocytosis were determined. Our results showed that treatment with B. trimera prevented the mentioned conditions, except for the production of hydrogen peroxide. B. trimera prevented the development of obesity and associated comorbidities, as well as activation of macrophages. In conclusion, B. trimera is able to prevent obesity and metabolic disorders and macrophages activation, minimizing inflammation and validating the popular use of this plant tea.

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Section: Introductionmentioning

confidence: 99%

Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice

et al. 2022

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“…B. trimera is a perennial subshrub popularly known as "carqueja" that belongs to the Asteraceae family, and its aerial parts are used as a tea, in order to treat several disorders [6,7]. According to phytochemical studies, flavonoids, terpenes, phenolic acids, and chlorogenic acids are the main classes of compounds that are identified in the aerial parts of B. trimera [8]. The literature has reported biological activities from this species as an antioxidant, anti-inflammation, liver and gastric protector, antimicrobial, antifungal, and antiparasitic [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…According to phytochemical studies, flavonoids, terpenes, phenolic acids, and chlorogenic acids are the main classes of compounds that are identified in the aerial parts of B. trimera [8]. The literature has reported biological activities from this species as an antioxidant, anti-inflammation, liver and gastric protector, antimicrobial, antifungal, and antiparasitic [8,9]. Furthermore, the polyphenols from B. trimera have shown great potential for anti-inflammatory properties that are associated with antioxidant activity, plus inhibitory enzymatic actions that are involved in the production of eicosanoids [10,11].…”

Section: Introductionmentioning

confidence: 99%

Baccharis trimera aqueous extract modulates inflammation and nociception in mice

et al. 2021

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Background The aerial parts of Baccharis trimera (Less.) are frequently used as a tea to treat several diseases. Therefore, the aim of this study was to identify the constituents of an aqueous extract of B. trimera, focusing on their antioxidant, anti-inflammation, and antinociception activities and properties. For that, the researchers performed in vivo assays using the formalin test and Freund’s Complete Adjuvant (FCA) to measure the acute and chronic inflammatory pain in mice. Moreover, the myeloperoxidase enzyme (MPO) was analyzed in the subcutaneous tissue after the FCA injection, together with the counting of lymphocytes in the peripheral blood of the mice. Results The qualitative phytochemical analysis indicated the presence of flavonoids and saponins in the B. trimera aqueous extract. The high-performance liquid chromatography (HPLC) analyses showed the presence of phenolic compounds, such as chlorogenic acid, ellagic acid, rosmarinic acid, as well as flavonoids, such as rutin, quercetin, and luteolin. The DPPH assay was used in order to measure the antioxidant activity of the aqueous extract of B. trimera and this showed an IC50 of 118.18 ± 1.02 μg/mg. The data from the formalin test demonstrated that a single dose of the aqueous extract of B. trimera was not able to decrease the nociceptive behavior during the neurogenic phase, at any of the tested doses (20, 40, or 80 mg/kg p.o.). However, during the inflammatory phase of this test, the aqueous extract of B. trimera at 80 mg/kg (p.o.) significantly decreased the nociceptive behavior, showing more effectiveness when compared to the other tested doses (p < 0.05). Importantly, in the chronic inflammatory model on the 5th day of treatment, the aqueous extract of B. trimera (80 mg/kg p.o.) significantly reduced mechanical allodynia (p < 0.01), heat thermal hyperalgesia (p < 0.001), and paw edema (p < 0.05). There were no changes in the MPO activity, but the data exhibited an equivalent decrease in the number of lymphocytes in the blood of the mice that were treated with B. trimera (80 mg.kg− 1 p.o.) and diclofenac sodium. Conclusion Taken together, the present data reinforces the potential of the B. trimera aqueous extract as an anti-inflammatory and analgesic compound.

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“…In Brazil, the Baccharis species, which have cladodes are popularly called "Carqueja" in Brazilian Portuguese, and they are used due to its medicinal properties, digestive, antimicrobial and anti-inflammatory effects, treatment of diabetes, liver dysfunctions and rheumatism (Rabelo & Costa, 2018;Fukuda, Ohkoshi, Makino, & Fujimoto, 2006;Gené et al, 1996;Oliveira, Endringer, Amorim, Brandão, & Coelho, 2005;Torres et al, 2000). Their chemical constituents are used in the synthesis of drugs and in the beverage industry due to the bitter taste (Campos et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Qualitative and Quantitative Evaluation Protocol of Baccharis Seed Germination

Moreno-Pizani¹,

Farias-Ramirez²,

Santos³

et al. 2019

JAS

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Baccharis trimera (Less.) DC (E1) and Baccharis crispa Spreng. (E2) possess potential antimicrobial and anti-inflammatory properties. Qualitative and quantitative information on seed germination on these species is scarce. The objective of this investigation was to establish a protocol for evaluating seed germination of E1 and E2 and to analice the scoring and curve fitting by the Germinator package, for different periods of germination were between 0.93 and 0.99. Both species showed differences in germinability and mean germination time, 27 days for E1 and 20 days for E2. The germination dispersion showed that E1 germination was homogeneous, with differences in growth pattern, whereas the results on germination of E2. The mean speed of germination determined with the experimental data was close to the values obtained by the Germinator package, with a maximum germination of more than 34%, proving that the software was efficient for evaluating germination.

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A review of biological and pharmacological activities of Baccharis trimera

Cited by 32 publications

References 81 publications

Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice

Baccharis trimera Infusion Reduces Macrophages Activation and High-Fat Diet-Induced Metabolic Disorders in Mice

Baccharis trimera aqueous extract modulates inflammation and nociception in mice

Qualitative and Quantitative Evaluation Protocol of Baccharis Seed Germination

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