A review of antimycobacterial natural products

Newton, Sandra M.; Lau, Clara Bik‐San; Wright, Colin W.

doi:10.1002/1099-1573(200008)14:5<303::aid-ptr712>3.0.co;2-n

Cited by 139 publications

(105 citation statements)

References 66 publications

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“…Therefore, potent new anti-tubercular drugs with novel modes of action and low toxicity are urgently needed to combat the threat of TB. Natural sources provide numerous examples of interesting secondary metabolites with antimycobacterial activity, indicating that natural products could be rewarding field for the discovery of new anti-TB leads (Newton et al, 2000;Copp, 2003;Pauli et al, 2005;Copp and Pearce, 2007). In Mozambique, where around 500 plant species are used as traditional medicine, people mainly rely on medicinal plants as their primary source for medication.…”

Section: Introductionmentioning

confidence: 99%

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Luo

Pires

Aínsa

et al. 2011

Journal of Ethnopharmacology

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Aims of the study: It was aimed to assess the in vitro antimycobacterial activity of crude extracts from fifteen medicinal plants and to reveal main classes of compounds which may account for the activity of extracts. Methods and materials:The plant materials were sequentially extracted by n-hexane, dichloromethane, ethyl acetate, and 70% ethanol. Decoction of each plant material was also prepared according to traditional use. Broth microdilution method was employed to screen extracts against two mycobacterial species: Mycobacterium smegmatis ATCC 607 and Mycobacterium tuberculosis H37Rv. The extracts with minimum inhibitory concentration(s) (MIC) below 125 g/mL were considered active and further tested against different mycobacterial species and strains, namely Mycobacterium tuberculosis H37Ra, Mycobacterium bovis BCG ATCC 35734, Mycobacterium smegmatis mc 2 155, Mycobacterium avium DSM 44156 and DSM 44157. Cytotoxic effect was evaluated against human macrophages from the monocytic THP-1 cells. Main classes of compounds in these active extracts were proposed from their 1 H NMR spectroscopic characterizations. Results: n-Hexane extracts of Maerua edulis and Securidaca longepedunculata, ethyl acetate extract of Tabernaemontana elegans and dichloromethane extract of Zanthoxylum capense were found to possess considerable activity against Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Ra with MIC 15.6-62.5 g/mL. Tabernaemontana elegans ethyl acetate extract displayed strong activity against Mycobacterium tuberculosis H37Rv (MIC 15.6 g/mL). Except for Tabernaemontana elegans ethyl acetate extract which presented potent cytotoxic effects in THP-1 cells (IC 50 < 4 g/mL), the other three plant extracts showed moderate to none toxicity. Based on 1 H NMR spectroscopic analysis, major components in both Maerua edulis and Securidaca longepedunculata n-hexane extracts were linear chain unsaturated fatty acids. Zanthoxylum capense dichloromethane extract contained more complex constituents (mostly phenolic compounds). In the most potent extract, Tabernaemontana elegans ethyl acetate extract, the prominent compounds were identified as indole alkaloids. Conclusions: The pronounced antimycobacterial activity of the medicinal plants Maerua edulis, Securidaca longepedunculata, Zanthoxylum capense, and Tabernaemontana elegans suggested that they might provide compounds which could be potential anti-TB drug leads.

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Section: Introductionmentioning

confidence: 99%

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Luo

Pires

Aínsa

et al. 2011

Journal of Ethnopharmacology

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“…There are approximately 250 000 higher plant species around the world, only 15% have been studied phytochemically and 6% have been screened for diverse biological activities (Fabricant and Farnsworth, 2001). Those with antimycobacterial activity are being studied by numerous researchers (Newton et al, 2000) resulting in the isolation and characterization of several active compounds (Copp, 2003;Okunade et al, 2004). Accordingly, the aim of this study was to evaluate the antimycobacterial activity of nine plants used in Mexican traditional medicine to treat tuberculosis and respiratory diseases, in addition to the study of those plants against a group of drug-resistant TB strains.…”

Section: Introductionmentioning

confidence: 99%

Activity against drug resistant‐tuberculosis strains of plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases

Ramírez-Cabrera

González-Santiago

Garza‐González

et al. 2007

Phytotherapy Research

101

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Tuberculosis (TB) kills about 3 million people per year worldwide. Furthermore, TB is an infectious disease associated with HIV patients, and there is a rise in multidrug‐resistant TB (MDR‐TB) cases around the world. There is a need for new anti‐TB agents. The study evaluated the antimycobacterial activity of nine plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases. Nasturtium officinale showed the best activity (MIC = 100 µg/mL) against the sensitive Mycobacterium tuberculosis. The following plants were active also but at 200 µg/mL: Citrus sinensis, Citrus aurantifolia, Foeniculum vulgare, Larrea tridentata, Musa acuminata and Olea europaea. Contrary to the above data, activity against drug‐resistant variants of M. tuberculosis was more evident, e.g. N. officinale was the most potent (MIC ≤ 100 µg/mL) against the four mono‐resistant variants tested; F. vulgare and O. europaea were active against all the resistant variants (MICs ≤ 100 µg/mL). The most susceptible variant was the isoniazid resistant, being inhibited by C. aurantifolia, C. sinensis and O. europaea (MIC = 25 µg/mL). These data point to the importance of biological testing of extracts against drug‐resistant M. tuberculosis isolates, and the bioguided assay of these extracts for the identification of lead compounds against MDR‐TB isolates. Copyright © 2007 John Wiley & Sons, Ltd.

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“…A number of studies have revealed the existence of a range of natural products with promising activity against mycobacteria (Newton, 2000;Cantrell, 2001).…”

Section: Introductionmentioning

confidence: 76%

“…Two fast growing species are M. aurum A+ and M. smegmatis MC2 and one slow growing is M. bovis PPI". This strain is used as a model to evaluate the effect of active substances on the growth of M. tuberculosis (Newton et al, 2000(Newton et al, , 2002. M. smegmatis and M. aurum have been shown to have similar profile of sensitivity to anti-tuberculosis drugs (Chung et al, 1995;Mitscher and Baker, 1998).…”

Section: Antimycobacterial Strains and Growth Conditionsmentioning

confidence: 99%

Extra- and intracellular antimycobacterial activity of Arbutus unedo L.

Ouarti¹,

Haouat²,

Sqalli³

et al. 2012

Afr. J. Microbiol. Res.

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This study aims to evaluate extra-and intracellullar antimycobacterial activity of Arbutus unedo L. leaves-extracts. We tested the aqueous and ethanol extracts of Arbutus leaves effect against three mycobacteria growth, and showed that aqueous extract and the part I of ethanol extract have a remarkable extracellular antimycobacterial activity. The MIC (Minimum inhibitory concentration) of the part I of ethanol extract is 5.59 ± 0.69 mg/ml for Mycobacterium aurum A + and 6.02 ± 0.76 mg/ ml for Mycobacterium smegmatis MC 2 and Mycobacterium bovis PPI. The part I of arbutus ethanol-extract, used at 6.02 ± 0.76 mg/ml, has a bactericidal effect on M. smegmatis MC 2 located within the rat peritoneal macrophages.

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A review of antimycobacterial natural products

Cited by 139 publications

References 66 publications

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique

Activity against drug resistant‐tuberculosis strains of plants used in Mexican traditional medicine to treat tuberculosis and other respiratory diseases

Extra- and intracellular antimycobacterial activity of Arbutus unedo L.

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