Extra- and intracellular antimycobacterial activity of Arbutus unedo L.

Ouarti, Asmae El; Haouat, Amina Cherif; Sqalli, Hakima; Haggoud, Abdellatif; Ennabili, Abdeslam; Koraichi, Saâd Ibnsouda; lachgar, Mohamed; Iraqui, Mohammed

doi:10.5897/ajmr11.1540

Cited by 17 publications

(3 citation statements)

References 48 publications

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“…Tuberculosis is caused by mycobacterial strains; for example, Mycobacterium tuberculosis , M. africanum , and M. bovis , identified cooperatively as the M. tuberculosis complex ( Haouat et al, 2012 ).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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Ocimum basilicum L. (O. basilicum) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of O. basilicum and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including “Ocimum basilicum,” “basilicums,” “linalool,” “respiratory disease,” “asthma,” “obstructive pulmonary disease,” “bronchodilatory,” “bronchitis,” “lung cancer,” and “pulmonary fibrosis,” and other related keywords.The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of O. basilicum and its constituent, linalool, on respiratory disorders.

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Section: Resultsmentioning

confidence: 99%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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“…The biological activity of A. unedo L. tree has been the subject of several studies (Delgado-Pelayo et al 2016;Erkekoglou et al 2017;Fonseca et al 2015). One of them reported from Portugual, in the survey, the extracts revealed antibacterial activity against several Gram-positive bacteria, including Bacillus cereus, Enterococcus faecalis and clinical methicillinresistant Staphylococcus aureus (Morgado et al 2018;Asmae et al 2012;Ertabaklar et al 2009;Ferreira et al, 2012). In another survey carried out again in Portugual, it was determined that the antimicrobial potential of the extract were more efficient to Gram-positive bacteria (Malherio et al 2012).…”

Section: Resultsmentioning

confidence: 99%

In vitro study on antioxidant, antibacterial and DNA interaction activities of extracts from Arbutus andrachne L.

Başkan¹

2019

Eurasian Journal of Forest Science

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Traditionally, the fruits and leaves of Arbutus (A.) andrachne are well known and used for applications in antimicrobial, antioxidant and anticancer activity. This study was aimed to determine in vitro antibacterial, antioxidant and DNA interaction activities of the different extracts of A. andrachne. A. andrachne was collected from Amasya Province during May 2018. Dried leaves powder were mixed with of suitable solvents. Then, the mixtures were extracted with the soxhlet apparatus for 4 hours. The antibacterial effects of extracts were researched on pathogens, namely Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 25953, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa ATCC 9027, Bacillus cereus ATCC 7064, Bacillus subtilis ATCC 6633, and Salmonella enteritidis ATCC 13076 using disc diffusion methods. Gentamicin and cefotaxime were used as the control for bacteria. To try to understand each plant extracts effect on the antioxidant methods, we studied the different methods as named radical scavenging activity (DPPH), metal chelating activity, ferric reducing antioxidant power assays. In the plant extracts, total phenolic and total flavonoid contents were determined by spectrophotometric methods due to investigating the effect of secondary metabolites on antioxidant activity. To explore the beneficial effect of the extracts on hydroxyl radical-mediated DNA damage, plasmid DNA pUC18 was used. As a result, A. andrachne extracts had an antibacterial effect when they compared with control group antibiotics. According to disc diffusion methods, the highest antibacterial effect was identified in ethanol, chloroform and hexane extract, respectively. Ethanol extract of A. andrachne showed the best antioxidant activity. Moreover, extracts of A. andrachne had repair effects on plasmid DNA in the presence of H2O2 condition. The investigated A. andrachne extract showed significant bioactivities. These extracts have been a promising candidate for the preparation of new natural products. However, future studies should be carried out to verify such actions in different matrices.

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“…A great diversity of extracts (using ethanol, methanol, hot water) constitute an interesting battery of antimicrobials, inhibiting the growth of S. aureus , P. aeruginosa , Escherichia coli , Enterococcus faecalis , Bacillus cereus and Mycobacterium spp. [ 52 , 53 , 54 , 80 , 81 ]. Moreover, silver nanoparticles prepared with an aqueous ST leave extract were also able to inhibit S. aureus , P. aeruginosa , E. coli and Staphylococcus epidermis [ 82 ].…”

Section: Antimicrobial/antiviral Activitymentioning

confidence: 99%

Use of Strawberry Tree (Arbutus unedo) as a Source of Functional Fractions with Biological Activities

Morales

2022

Foods

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Arbutus unedo, commonly named ‘strawberry tree’ (ST), is a Mediterranean native plant that represents a relevant source of biologically active fractions and compounds. ST fruits, traditionally used with culinary and medicinal purposes, along with other components (leaves, roots, honeys, etc.), have been subjected to varied extraction procedures to obtain enriched and bioactive products. This work reviewed the scientific literature, searching for studies that evaluated the potential health implications of ST fractions and attending to the tested biological activities (antioxidant, antiproliferative, hypoglycemic, immune-modulatory, antihypertensive, antimicrobial, etc.), the part of the tree, the experimental model, the specific bioactive compounds and the selected extraction protocol. Furthermore, the strengths and weaknesses of the current state of the published evidence were critically analysed. Although in vitro results demonstrated the potential of ST fractions, further research is encouraged in order to obtain in vivo evidence (animal and clinical studies), assess additional activities (hypocholesterolemic, microbiome-modulatory), maximize the use of advanced extraction technologies, purify and isolate specific bioactive compounds and broaden the analysis investigating phenolic and non-phenolic molecules and their bioavailability.

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Extra- and intracellular antimycobacterial activity of Arbutus unedo L.

Cited by 17 publications

References 48 publications

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

In vitro study on antioxidant, antibacterial and DNA interaction activities of extracts from Arbutus andrachne L.

Use of Strawberry Tree (Arbutus unedo) as a Source of Functional Fractions with Biological Activities

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