A review of antiepileptic drugs: Part 1 occurrence, fate in aquatic environments and removal during different treatment technologies

Cardoso-Vera, Jesús Daniel; Elizalde-Velázquez, Gustavo Axel; Islas-Flores, Hariz; Mejía-García, Alejandro; Ortega-Olvera, José Mario; Gómez-Oliván, Leobardo Manuel

doi:10.1016/j.scitotenv.2021.145487

Cited by 24 publications

(3 citation statements)

References 146 publications

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“…On the one hand, due to the influence of the metabolism of antiepileptic drugs (AEDs) during pregnancy and the clear or potential teratogenicity of AEDs to the fetus, it brings difficulties to clinical treatment [ 7 , 8 ]. On the other hand, with the rich selection of AEDs and the increase in the range of indications (such as pain, migraine, and mood disorders), the number of female patients treated with AEDs during pregnancy has increased significantly [ 9 , 10 ]. Faced with this situation, clinicians should actively seek countermeasures and choose appropriate AEDs to treat epilepsy during pregnancy, so as to provide a favorable guarantee for the safety of mothers and babies in this group.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Clinical Effects of Sodium Valproate and Levetiracetam in the Treatment of Women with Epilepsy during Pregnancy

Zhao

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the clinical effects of sodium valproate and levetiracetam in the treatment of women with epilepsy during pregnancy. Methods. The clinical data of 124 women with epilepsy during pregnancy who received monotherapy with antiepileptic drugs (AEDs) in our hospital from September 2017 to January 2020 were retrospectively analyzed. According to the type of medication taken by the patients, they were recorded as the sodium valproate group (the VPA group, n = 56) and the levetiracetam group (the LEV group, n = 68 cases). The effects and the maternal and infant outcomes after treatment were compared between the two groups. The neuron-specific enolase (NSE), cognitive function-related parameters (brain-derived neurotrophic factor (BDNF) and myelin basic protein (MBP)), and related inflammatory factors (tumor necrosis factor- (TNF-) α and interleukin- (IL-) 6) levels were compared between the two groups before and after treatment. Results. After treatment, the total clinical effective rate of the LEV group was 91.18% higher than that of the VPA group 73.21%, and the frequency and duration of seizures were lower than those of the VPA group ( P < 0.05 ). After treatment, the probability of gestational hypertension, depression during pregnancy, low-weight infants, and neonatal deformities in the LEV group was lower than that in the VPA group ( P < 0.05 ). After treatment, the levels of NSE, MBP, TNF-α, and IL-6 in the two groups decreased, and the levels of BDNF increased, and the LEV group changed significantly compared with the VPA group ( P < 0.05 ). Conclusion. Compared with sodium valproate monotherapy, levetiracetam is more effective in controlling seizures and improving maternal and infant outcomes in women with epilepsy during pregnancy and can effectively regulate their neurological and cognitive functions and reduce the serum inflammation factor level.

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Section: Introductionmentioning

confidence: 99%

Analysis of the Clinical Effects of Sodium Valproate and Levetiracetam in the Treatment of Women with Epilepsy during Pregnancy

Zhao

2021

Evidence-Based Complementary and Alternative Medicine

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“…Of all the emerging contaminants, the ones that probably cause the most significant concern are medicines. Their study is among the priority lines of research of leading organizations dedicated to protecting the public and environmental health, such as the World Health Organization, the Environmental Protection Agency, and the European Commission ( de Wilt et al, 2016 , Cardoso-Vera et al, 2021 ). Some of the most used medications are analgesics and anti-inflammatories.…”

Section: Introductionmentioning

confidence: 99%

Ecofriendly and sustainable Sargassum spp.-based system for the removal of highly used drugs during the COVID-19 pandemic

López-Miranda

Molina

Esparza

et al. 2022

Arabian Journal of Chemistry

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“…Quando descartados em locais inadequados, esses resíduos de medicamentos tornam-se um ameaça para o ambiente e, por consequência para a saúde da população (BUNGAU; BUNGAU; TIT, 2015). Diante disso é importante que sejam determinados seu destino e abundância, para que seja possível prever, regular e compreender os seus riscos (CARDOSO-VERA et al, 2021).…”

Section: Fármacos No Ambienteunclassified

Ocorrência e ecotoxicidade de antidepressivos residuais em amostras do Rio Piracicaba (SP)

Evangelista¹

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Antidepressants are pharmaceutical products considered to be micropollutants and can cause behavioral changes that affect families' dynamics in casualties. After administration, most of these substances are excreted unchanged or as active metabolites. The objective of the study was to adapt and validate a methodology based on solid phase extraction (SPE) and high-performance liquid chromatography coupled to a mass spectrometer with electrospray ionization source (HPLC-MS / MS) to analyze and monitor antidepressants venlafaxine, citalopram, fluoxetine and sertraline in water collected in four different spots of the Piracicaba River over seven consecutive days during the drought season. Validation process was carried out according to the criteria of the regulatory agency, Anvisa. The method demonstrated acceptable accuracy (76-119.8%) and precision (DPR <15%), high selectivity, and the LDs and LQs shows that the method is sensitive. All the antidepressants analyzed were detected in the concentration range of 1.0 to 4.48 ng L-1. In some places, the continuous presence of antidepressants was detected. Fluoxetine and sertraline were the compounds that had the most frequent detections. We hope that this study could serve as a guiding basis for the inclusion in the Brazilian legislation of drugs monitoring in aquatic environment.

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A review of antiepileptic drugs: Part 1 occurrence, fate in aquatic environments and removal during different treatment technologies

Cited by 24 publications

References 146 publications

Analysis of the Clinical Effects of Sodium Valproate and Levetiracetam in the Treatment of Women with Epilepsy during Pregnancy

Analysis of the Clinical Effects of Sodium Valproate and Levetiracetam in the Treatment of Women with Epilepsy during Pregnancy

Ecofriendly and sustainable Sargassum spp.-based system for the removal of highly used drugs during the COVID-19 pandemic

Ocorrência e ecotoxicidade de antidepressivos residuais em amostras do Rio Piracicaba (SP)

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