A review of accelerated wound healing approaches: biomaterial- assisted tissue remodeling

Nour, Shirin; Baheiraei, Nafiseh; Imani, Rana; Khodaei, Mohammad; Alizadeh, Akram; Rabiee, Navid; Moazzeni, Seyed Mohammad

doi:10.1007/s10856-019-6319-6

Cited by 85 publications

(67 citation statements)

References 98 publications

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“…Therefore, the greatest benefit of aptamers based on oligonucleotides over antibodies based on proteins is their constant properties at high temperatures, even after a 95°C denaturation. [10][11][12][13] Aptamers are minimally toxic molecules with low immunogenicity because nucleic acids usually are not recognized as an external, foreign agent by the human immune system. 14,15 Aptamers are derived from SELEX (Systematic Evolution of Ligands by Exponential Enrichment) or in vitro evolutionary processes, so toxins and other molecules that do not induce a strong immune response can be used as the object to develop aptamers.…”

Section: Introductionmentioning

confidence: 99%

Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

Rabiee¹,

Ahmadi²,

Arab³

et al. 2020

IJN

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With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.

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Section: Introductionmentioning

confidence: 99%

Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

Rabiee¹,

Ahmadi²,

Arab³

et al. 2020

IJN

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“…Thus, there is an urgent demand to develop new methods to repair damaged cardiac tissue. [9][10][11] Recently, cardiac tissue engineering has emerged as a promising approach to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in an organism, thereby regenerating tissues for a fully functioning heart without side effects such as immune rejection. 12 Tissue engineers can now provide highly controllable three-dimensional environments to mediate cell differentiation and promote functional assembly for use as high-fidelity models to study cardiac development and CVD.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine

Nasr¹,

Rabiee²,

Hajebi³

et al. 2020

IJN

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Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/ synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.

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“…Nanotechnology has brought widespread benefits to various fields of science, particularly in the biomedical sciences. [2][3][4][5] Nanostructures provide a wide range of applications in the areas of molecular imaging, early disease diagnosis, drug delivery, and tissue engineering to name a few due to their shape, size, surface charge, and functional groups.…”

Section: Introductionmentioning

confidence: 99%

The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy

Nasseri¹,

Türk²,

Kösemehmetoğlu³

et al. 2020

IJN

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Background: The development of highly efficient nanoparticles to convert light to heat for anti-cancer applications is quite a challenging field of research. Methods: In this study, we synthesized unique pimpled gold nanospheres (PGNSs) for plasmonic photothermal therapy (PPTT). The light-to-heat conversion capability of PGNSs and PPTT damage at the cellular level were investigated using a tissue phantom model. The ability of PGNSs to induce robust cellular damage was studied during cytotoxicity tests on colorectal adenocarcinoma (DLD-1) and fibroblast cell lines. Further, a numerical model of plasmonic (COMSOL Multiphysics) properties was used with the PPTT experimental assays. Results: A low cytotoxic effect of thiolated polyethylene glycol (SH-PEG 400-SH-) was observed which improved the biocompatibility of PGNSs to maintain 89.4% cell viability during cytometry assays (in terms of fibroblast cells for 24 hrs at a concentration of 300 µg/ mL). The heat generated from the nanoparticle-mediated phantom models resulted in ΔT=30°C, ΔT=23.1°C and ΔT=21°C for the PGNSs, AuNRs, and AuNPs, respectively (at a 300 µg/mL concentration and for 325 sec). For the in vitro assays of PPTT on cancer cells, the PGNS group induced a 68.78% lethality (apoptosis) on DLD-1 cells. Fluorescence microscopy results showed the destruction of cell membranes and nuclei for the PPTT group. Experiments further revealed a penetration depth of sufficient PPTT damage in a physical tumor model after hematoxylin and eosin (H&E) staining through pathological studies (at depths of 2, 3 and 4 cm). Severe structural damages were observed in the tissue model through an 808-nm laser exposed to the PGNSs. Conclusion: Collectively, such results show much promise for the use of the present PGNSs and photothermal therapy for numerous anti-cancer applications.

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A review of accelerated wound healing approaches: biomaterial- assisted tissue remodeling

Cited by 85 publications

References 98 publications

<p>Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review</p>

<p>Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review</p>

<p>Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine</p>

<p>The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy</p>

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