2017
DOI: 10.1126/scitranslmed.aan3879
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A reversible thermoresponsive sealant for temporary closure of ocular trauma

Abstract: Open globe injuries are full-thickness injuries sustained to the eye wall (cornea or sclera), which cause immediate drops in intraocular pressure that may lead to retinal detachment and permanent vision loss if not treated rapidly after injury. The current standard of care for open globe injuries consists of suturing the margins closed, but the technique can be time-consuming, requires specialized training and equipment, and can lead to patient discomfort, abrasion, and infection from eye rubbing. We engineere… Show more

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Cited by 63 publications
(66 citation statements)
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“…Hydrogels are a class of three-dimensional (3D) networks formed by hydrophilic polymer chains embedded in a water-abundant environment, which can swell and shrink in response to certain stimuli, for example, light, pH, temperature, biochemical processes, and electric and magnetic fields. With the abilities to change their volumes sizably and reversibly, together with structures and functionalities comparable to biological systems, hydrogels favor competent applications in traumatic injuries, tissue engineering, and biosensors [13][14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%
“…Hydrogels are a class of three-dimensional (3D) networks formed by hydrophilic polymer chains embedded in a water-abundant environment, which can swell and shrink in response to certain stimuli, for example, light, pH, temperature, biochemical processes, and electric and magnetic fields. With the abilities to change their volumes sizably and reversibly, together with structures and functionalities comparable to biological systems, hydrogels favor competent applications in traumatic injuries, tissue engineering, and biosensors [13][14][15][16][17].…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, the TAPTRA patch withstood a much higher pressure at an environmental temperature of 32–35 °C. Leakage from the incision was only observed at pressures of 44–45 mmHg, which is far beyond the normal IOP ranges in 12–22 mmHg . Rinsing with cold water quickly transformed the gel to a transparent state with a compromised cohesive strength, causing leakage at a much lower pressure (≈12 mmHg on both the cornea and sclera tissues).…”
Section: Resultsmentioning
confidence: 96%
“… 50 52 Reversible thermo-responsive sealants have been applied for temporary closure of surgical incisions or traumatic injuries of the sclera and cornea. 53 Moreover, intrascleral delivery of in situ thermo-responsive implants have been tested with a microneedle injection system. 54 However, most currently available IVT devices are in solid form.…”
Section: Discussionmentioning
confidence: 99%