A reusable evanescent wave immunosensor for highly sensitive detection of bisphenol A in water samples

Zhou, Xiaoguang; Liu, Lanhua; Xu, Wei; Song, Biao; Sheng, Jian-Wu; He, Mengchang; Shi, Hanchang

doi:10.1038/srep04572

Cited by 53 publications

(22 citation statements)

References 38 publications

(67 reference statements)

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“…In addition, a reusable evanescent wave immunosensor has been employed for highly sensitive detection of BPA in water samples. Typical calibration curves showed a detection limit of 0.03 μg·L −1 for BPA [ 157 ].…”

Section: Aptasensors and Their Applications For Detecting Low Molementioning

confidence: 99%

Practical Application of Aptamer-Based Biosensors in Detection of Low Molecular Weight Pollutants in Water Sources

et al. 2018

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Water pollution has become one of the leading causes of human health problems. Low molecular weight pollutants, even at trace concentrations in water sources, have aroused global attention due to their toxicity after long-time exposure. There is an increased demand for appropriate methods to detect these pollutants in aquatic systems. Aptamers, single-stranded DNA or RNA, have high affinity and specificity to each of their target molecule, similar to antigen-antibody interaction. Aptamers can be selected using a method called Systematic Evolution of Ligands by EXponential enrichment (SELEX). Recent years we have witnessed great progress in developing aptamer selection and aptamer-based sensors for low molecular weight pollutants in water sources, such as tap water, seawater, lake water, river water, as well as wastewater and its effluents. This review provides an overview of aptamer-based methods as a novel approach for detecting low molecular weight pollutants in water sources.

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Section: Aptasensors and Their Applications For Detecting Low Molementioning

confidence: 99%

Practical Application of Aptamer-Based Biosensors in Detection of Low Molecular Weight Pollutants in Water Sources

et al. 2018

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“…While the sensing principles differ in their operation mechanisms, the general strategy is to rapidly detect the presence of a target such as metabolites, nucleic acids, proteins, ions, or microorganisms based on a contrast generation around fiber surfaces . Evanescent wave fiber biosensors are preferred for sensing as they rely on confined light around the outer region of a fiber that is generated upon reflection of light within the fiber inner interfaces . Since fibers are compact and lightweight, fiber biosensors present ideal platforms for field use.…”

Section: Optical Devices and Materialsmentioning

confidence: 99%

Portable Multiplex Optical Assays

Coşkun

Topkaya

Yetisen

et al. 2018

Advanced Optical Materials

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performed at home and results can be integrated by online interfaces. [5] The test results and diagnostic information can be analyzed by the medical professionals from remote locations, improving the connectivity of central hubs to the public venues.Numerous scientific discoveries have been made in advanced settings and wellequipped laboratories. The necessity and complexity of these environments limit access to research equipment worldwide. Thus, decentralization of research laboratories has become an alternative solution to improve access to experimentation in field conditions. For instance, a paper origami microscope [6] that fit into a palm of a student made a powerful investigation tool for environment and materials. A detailed analysis of sound recordings by smartphones enabled identification of distinct mosquitoes. [7] These fielddeployable devices and platforms have stimulated emergence of citizen scientists, a population that collectively performs scientific inquiries in public settings.Rich biomolecular measurements from field-portable devices improve the quality of results in terms of accuracy and depth. Monitoring multiple blood markers has enabled diagnostic precision and thorough scientific investigation of blood constituent in patients. Therefore, field-deployable devices should ideally have multiplexed detection of target specimens. Design of such multiplexed detection technologies requires decent complexity at low cost for wide-scale adoptability.In this article, we provide an overview of field-compatible devices with high parameter analysis capabilities for both health monitoring purposes and scientifically enlightening Global health issues are increasingly becoming critical with high fatality rate due to chronic and infectious diseases. Emerging technologies aim to address these problems by understanding the causes of lethal conditions and diagnosing symptoms at early stage. Existing commercial diagnostics primarily focus on single-plex assays due to ease-of-use, simplicity in analysis, and amenability to mass manufacturing. Many research grade devices have utilized only a few molecular and morphological signatures in bodily fluids. However, multiplex devices can improve accuracy, sensitivity, and scalability of research and diagnostic devices. This review presents multiplex assays that utilize optical, electrical, and chemical methods and materials that have the potential to improve portable point-of-care diagnostics. The critical role of emerging optical and complementary assays with multiple contrast mechanisms is investigated to enable highly multiplex analysis in field settings. Multiparameter portable devices for field applications toward health monitoring, food testing, air quality monitoring, and microanalysis in other extreme conditions are examined. Current trends indicate the need for validation of health diagnosis based on a large number of biomarkers in randomized clinical trials. Advanced digital analysis, crowdsourced solutions, and robust user interfaces will become an integral ...

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“…Recentemente, um enorme interesse tem sido voltado à fabricação de dispositivos usando plataformas de óptica integrada (lab-on-a--chip). Guias de onda ópticos (fibra óptica e guia de onda planar) têm sido amplamente usados como sensores químicos, bioquímicos, biológicos 4,5,23,24 usando especialmente superfícies funcionalizadas com corantes químicos, marcadores fluorescentes ou receptores biológicos permitindo seletividade na detecção de determinado analito. 23 Em alguns estudos, a utilização de bio-sensores que utilizam plataforma de guias de onda planar com redes de difração para injeção da luz, permitem a detecção de uma vasta gama de biomoléculas, componentes celulares e células cancerígenas.…”

Section: Sensoresunclassified