A Reusable Capacitive Immunosensor Based on a CuS Ultrathin Film Constructed by Using a Surface Sol-Gel Technique

Wu, Zhan; Cao, Zhong; Zeng, Ju‐Lan; Zhang, Ling; Chu, Xia; Shen, Guo‐Li; Yu, Ru‐Qin

doi:10.2116/analsci.26.1001

Cited by 10 publications

(4 citation statements)

References 31 publications

(29 reference statements)

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“…Another approach used for the detection of protein molecules involved designing potentiometric-based biosensors, which consisted of the measurement of potentials at the working electrode with respect to the reference electrode . An insulating ultrathin CuS film, prepared by using a sol-gel technique, was used to detect immunoglobulin, in which the thinness and insulating behavior of the sol-gel CuS films allowed the capacitance changes to be measured via a potentiostatic-step . Less conventional electrochemical sensors using CuS NCs have also been developed.…”

Section: Sensorsmentioning

confidence: 99%

Compound Copper Chalcogenide Nanocrystals

et al. 2017

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This review captures the synthesis, assembly, properties, and applications of copper chalcogenide NCs, which have achieved significant research interest in the last decade due to their compositional and structural versatility. The outstanding functional properties of these materials stems from the relationship between their band structure and defect concentration, including charge carrier concentration and electronic conductivity character, which consequently affects their optoelectronic, optical, and plasmonic properties. This, combined with several metastable crystal phases and stoichiometries and the low energy of formation of defects, makes the reproducible synthesis of these materials, with tunable parameters, remarkable. Further to this, the review captures the progress of the hierarchical assembly of these NCs, which bridges the link between their discrete and collective properties. Their ubiquitous application set has cross-cut energy conversion (photovoltaics, photocatalysis, thermoelectrics), energy storage (lithium-ion batteries, hydrogen generation), emissive materials (plasmonics, LEDs, biolabelling), sensors (electrochemical, biochemical), biomedical devices (magnetic resonance imaging, X-ray computer tomography), and medical therapies (photochemothermal therapies, immunotherapy, radiotherapy, and drug delivery). The confluence of advances in the synthesis, assembly, and application of these NCs in the past decade has the potential to significantly impact society, both economically and environmentally.

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Section: Sensorsmentioning

confidence: 99%

Compound Copper Chalcogenide Nanocrystals

et al. 2017

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“…Besides sensing of various molecules such as DNA and glucose, several literature reports also focused on the in vitro uses of CuS nanoparticles for other applications. For example, a CuS thin film modified capacitive immunosenor was developed for the detection of human IgA antibody in serum samples, in which a goat anti‐human IgA antibody was immobilized on the CuS thin film electrodes . In another report, an electrochemical immunosensor based on CuS nanoparticle‐MWNT composite electrodes was constructed for the detection of food borne pathogens (e.g., alpha‐salmonella), which can have applications in mitigating food and water poisoning .…”

Section: Biomedical Applications Of Cus Nanoparticlesmentioning

confidence: 99%

“…In another report, an electrochemical immunosensor based on CuS nanoparticle‐MWNT composite electrodes was constructed for the detection of food borne pathogens (e.g., alpha‐salmonella), which can have applications in mitigating food and water poisoning . In both reports, the immunosensors were found to be reusable, sensitive, and specific to the desired analytes . In an interesting study, bioactive nanocrystalline and amorphous CuS was found to specifically and significantly induce apoptosis of human cancer cells by entering the cells and localizing in specific organelles, thereby producing an anti‐proliferative response .…”

Section: Biomedical Applications Of Cus Nanoparticlesmentioning

confidence: 99%

Synthesis and Biomedical Applications of Copper Sulfide Nanoparticles: From Sensors to Theranostics

Goel

Chen

Cai

2013

Small

412

277

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Copper sulfide (CuS) nanoparticles have attracted increasing attention from biomedical researchers across the globe, because of their intriguing properties which have been mainly explored for energy- and catalysis-related applications to date. This focused review article aims to summarize the recent progress made in the synthesis and biomedical applications of various CuS nanoparticles. After a brief introduction to CuS nanoparticles in the first section, we will provide a concise outline of the various synthetic routes to obtain different morphologies of CuS nanoparticles, which can influence their properties and potential applications. CuS nanoparticles have found broad applications in vitro, especially in the detection of biomolecules, chemicals, and pathogens which will be illustrated in detail. The in vivo uses of CuS nanoparticles have also been investigated in preclinical studies, including molecular imaging with various techniques, cancer therapy based on the photothermal properties of CuS, as well as drug delivery and theranostic applications. Research on CuS nanoparticles will continue to thrive over the next decade, and tremendous opportunities lie ahead for potential biomedical/clinical applications of CuS nanoparticles.

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“…A number of papers investigated the development of immunosensors that were not based on QCM as the primary detection method (Fu et al ., ; Fu et al ., ; Kim et al ., ; Malhotra et al ., ; Neng et al ., ; Wu et al ., ). Rather QCM was used as a tool to independently characterise and ensure controlled fabrication of interfacial layer at the sensor surface.…”

Section: Protein Interactionsmentioning

confidence: 97%

A Survey of the 2010 Quartz Crystal Microbalance Literature

Speight

Cooper

2012

J of Molecular Recognition

133

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In 2010 there has again been an increase in the number of papers published involving piezoelectric acoustic sensors, or quartz crystal microbalances (QCM), when compared to the last period reviewed 2006-2009. The average number of QCM publications per annum was 124 in the period 2001-2005, 223 in the period 2006-9, and 273 in 2010. There are trends towards increasing use of QCM in the study of protein adsorption to surfaces (93% increase), homeostasis (67% increase), protein-protein interactions (40% increase), and carbohydrates (43% increase). New commercial systems have been released that are driving the uptake of the technology for characterisation of binding specificities, affinities, kinetics and conformational changes associated with a molecular recognition event. This article highlights theoretical and practical aspects of the principals that underpin acoustic analysis, then reviews exemplary papers in key application areas involving small molecular weight ligands, carbohydrates, proteins, nucleic acids, viruses, bacteria, cells, and membrane interfaces.

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A Reusable Capacitive Immunosensor Based on a CuS Ultrathin Film Constructed by Using a Surface Sol-Gel Technique

Cited by 10 publications

References 31 publications

Compound Copper Chalcogenide Nanocrystals

Compound Copper Chalcogenide Nanocrystals

Synthesis and Biomedical Applications of Copper Sulfide Nanoparticles: From Sensors to Theranostics

A Survey of the 2010 Quartz Crystal Microbalance Literature

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