A reusable biosensor for detecting mercury(ii) at the subpicomolar level based on “turn-on” resonance light scattering

Yue, Qiaoli; Shen, Tongfei; Wang, Junting; Wang, Lei; Xu, Shuling; Li, Haibo; Liu, Jifeng

doi:10.1039/c3cc38488h

Cited by 56 publications

(16 citation statements)

References 26 publications

(2 reference statements)

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“…Thus, the detection of resonance light scattering (RLS) could be a very sensitive approach for aggregation-based plasmonic L. Guo et al nanosensors. In fact, this detection mechanism has been extensively used for the sensitive assay of DNA [228][229][230], proteins [231][232][233], small molecules [234][235][236][237] and metal ions [238][239][240]. The hyper-Rayleigh scattering (HRS) technique can determine the microscopic nonlinear optical properties of species in solution.…”

Section: Scattering Signals Of Plasmonic Couplingmentioning

confidence: 99%

Strategies for enhancing the sensitivity of plasmonic nanosensors

et al. 2015

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Based on the localized surface plasmon resonance (LSPR) of metallic nanoparticles, plasmonic nanosensors have emerged as a powerful tool for biosensing applications. Many detection schemes have been developed and the field is rapidly growing to incorporate new methodologies and applications. Amidst all the ongoing research efforts, one common factor remains a key driving force: continued improvement of high-sensitivity detection. Although there are many excellent reviews available that describe the general progress of LSPR-based plasmonic biosensors, there has been limited attention to strategies for improving the sensitivity of plasmonic nanosensors. Recognizing the importance of this subject, this review highlights recent progress on different strategies used for improving the sensitivity of plasmonic nanosensors. These strategies are classified into the following three categories based on their different sensing mechanisms: (1) sensing based on target-induced local refractive index changes, (2) colorimetric sensing based on LSPR coupling, and (3) amplification of detection sensitivity based on nanoparticle growth. The basic principles and cutting-edge examples are provided for each kind of strategy, collectively forming a unifying framework to view the latest attempts to improve the sensitivity of nanoplasmonic sensors. Future trends for the fabrication of improved plasmonic nanosensors are also discussed.

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Section: Scattering Signals Of Plasmonic Couplingmentioning

confidence: 99%

Strategies for enhancing the sensitivity of plasmonic nanosensors

et al. 2015

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“…It has the advantages of simplicity, rapidness and high sensitivity. RLS method has been used for the determination of various target analytes, including inorganic ions [13,14], organic medicines [15][16][17] and biological macromolecules [18][19][20][21], as well as the interactions of medicines with biological macromolecules [22,23]. However, until now, RLS method has hardly been used for the determination of ATP.…”

Section: Introductionmentioning

confidence: 98%

Determination of ATP by resonance light scattering using a binuclear uranyl complex and aptamer modified gold nanoparticles as optical probes

Liao

et al. 2014

Microchim Acta

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We describe a resonance light scattering (RLS) method for the direct detection of adenosine triphosphate (ATP) in aqueous solution without the need for separation. The binuclear uranyl complex bis-uranyl-bis-sulfosalophen (BUBSS) was synthesized by the coordination reaction of two uranyl ions with the ditopic tetradentate ligand bissulfosalophen. In parallel, gold nanoparticles were modified with anti-ATP aptamer (Apt-AuNPs) to serve as RLS probes. The detection scheme is based on the specific reaction of a BUBSS molecule with two ATP molecules to form a linear supramolecule. This, in turn, binds two Apt-AuNPs molecules, and this is accompanied by the aggregation of the Apt-AuNPs and results in a strong RLS signal. A RLS method was developed on this basis that has a linear response to ATP in the 5 to 500 nM concentration range, with a 4.5 nM detection limit under optimal conditions. The method has been successfully applied to the detection of ATP in spiked real samples and gave recoveries between 96.3 and 102.5 %.

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“…RLS belongs to the special application of Rayleigh scattering (RS), when the wavelength of Rayleigh scattering (RS) is located at or close to the molecular absorption band, rescattering takes place because of the absorption of light energy of the electron [15,16]. RLS technique has been proposed for the determination of biomacromolecules [17,18], pharmaceuticals [19], and inorganics [20][21][22] by virtue of extremely excellent sensitivity and fast analysis speed. Thus, great attention has been focused on it in recent years.…”

Section: Introductionmentioning

confidence: 99%

Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application

et al. 2016

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A novel, highly selective, and sensitive resonance light scattering (RLS) detection approach coupled with high performance liquid chromatography (HPLC) was researched and developed for the synchronous analysis of three kinds of benzimidazole anthelmintics, including mebendazole (MBZ), albendazole (ABZ), and fenbendazole (FBZ) for the first time. In the pH range of 3.5-3.7 Britton-Robinson buffer medium, three kinds of anthelmintics, which were separated by HPLC, reacted with eosin Y (EY) to form 1:1 ion-association complexes, resulting in significantly enhanced RLS signals and the maximum peak located at 335 nm. The enhanced RLS intensity was in proportion to the MBZ, ABZ, and FBZ concentration in the range 0.2-25, 0.2-23, and 0.15-20 μg/mL, respectively. The limit of detection was in the range of 0.064-0.16 μg/mL. In addition, human urine was determined to validate the proposed method by spiked samples and real urine samples. Satisfactory results were obtained by HPLC-RLS method. Graphical Abstract The diagram mechanism of generating resonance between emitted light and scattered light.

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A reusable biosensor for detecting mercury(ii) at the subpicomolar level based on “turn-on” resonance light scattering

Cited by 56 publications

References 26 publications

Strategies for enhancing the sensitivity of plasmonic nanosensors

Strategies for enhancing the sensitivity of plasmonic nanosensors

Determination of ATP by resonance light scattering using a binuclear uranyl complex and aptamer modified gold nanoparticles as optical probes

Study on the interaction between three benzimidazole anthelmintics and eosin Y by high performance liquid chromatography associating with resonance light scattering and its application

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