A Retrospective Study on Urinary Tract Infection Agents Isolated from Children and Their Antibiotic Susceptibility

İdil, Neslihan; Candan, Esra Deniz; Rad, Abbas Yousefi

doi:10.15671/hjbc.639411

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…The resistance rates of Klebsiella to ampicillin, AMC, TMP-SMX, cefuroxime, and nitrofurantoin were found to be high, similar to previous studies in the literature [15,18]. In addition, we observed that Klebsiella had low rates of resistance to amikacin and meropenem, which is in agreement with the findings of Duicu et al and İdil et al [13,19]. We found no significant increase in the antibiotic resistance rates of Klebsiella spp.…”

Section: Discussionsupporting

confidence: 92%

Antibiotic Resistance Patterns in Pediatric Urinary Tract Infections: A Comparison Between 2013-2015 and 2019-2021 Pediatrik İdrar Yolu Enfeksiyonlarında Antibiyotik Direnç Paternleri: 2013-2015 ve 2019-2021 Arasında Bir Karşılaştırma

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Ertan

2022

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Objective: Urinary tract infections (UTIs) are one of the most common infections in children. The aim of this study was to assess and compare the etiology and antibiotic susceptibility results of urine cultures obtained between 2013-2015 and 2019-2021 and evaluate local epidemiologic differences over years. Materials and Methods: A total of 1,000 samples with positive urine cultures (500 cultures each for the 2013-2015 and 2019-2021 periods) and antibiogram results were included in this study. Results: The most grown uropathogens were Escherichia coli and Klebsiella spp. in both two periods. E. coli and Klebsiella spp. showed high resistance to ampicillin, amoxicillin, trimethoprim-sulfamethoxazole, cefuroxime, and ceftriaxone. The resistance rates of E. coli to ampicillin, amoxicillin and trimethoprim-sulfamethoxazole were reported as 65%, 46%, and 45%, respectively and significantly increased in 2019-2021 compared to 2013-2015 (p

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Section: Discussionsupporting

confidence: 92%

Antibiotic Resistance Patterns in Pediatric Urinary Tract Infections: A Comparison Between 2013-2015 and 2019-2021 Pediatrik İdrar Yolu Enfeksiyonlarında Antibiyotik Direnç Paternleri: 2013-2015 ve 2019-2021 Arasında Bir Karşılaştırma

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Ertan

2022

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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“…In studies conducted in Turkiye, E. coli, Klebsiella spp., and Enterobacter spp. are reported to be the most common pathogens with growth in culture (24)(25)(26). Similar to our study, Bozkurt et al also found that Proteus spp.…”

Section: Sixtysupporting

confidence: 91%

“…Gökçe et al reported that the resistance rate was 71% for ampicillin, 43% for ACA, 31% for trimethoprim/sulfamethoxazole (TMP-SMX), 14% for ceftriaxone, and 4% for amikacin (32). In another study, İdil et al determined the resistance rate as 70.2% for ampicillin, 49% for ACA, and 37.1% for TMP-SMX, 34.2% for ceftriaxone, and 1.3% for amikacin resistance (26). In our study, the resistance rates of ceftriaxone and amikacin were determined as 25.9% and 5.6%, respectively.…”

Section: Sixtymentioning

confidence: 99%

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Evaluation of Urinary Tract Infections in Pediatric Patients Admitted to the Emergency Department

et al. 2023

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Background/Aim: Urinary tract infections (UTIs) are among the most common infections in children and one of the important reasons for presentation to the pediatric emergency department. This study aimed to determine demographic characteristics, complaints, microorganisms isolated in urine culture analysis, and antibiotic resistance rates in pediatric patients diagnosed with UTIs. Material and Method: The data of patients aged under 18 years, who presented to our hospital from January 1, 2020, through December 31, 2020 with a preliminary diagnosis of UTIs and underwent urine culture analysis, were retrospectively screened from the computer registry system. The patients’ demographic characteristics, complaints, microorganisms isolated in urine culture analysis, and antibiotic resistance were evaluated. Results: The mean age of the 286 patients included in the study was 75.5±57.65 months, and 238 (83.2%) were girls. The most common complaint at presentation was dysuria (39.9%), followed by fever (35.3%) and abdominal pain (26.9%). In urine culture analysis, the most frequently detected microorganisms were Escherichia coli (n=242, 84.6%), Proteus spp. (n=21, 7.3%), and Klebsiella spp. (n=16, 5.6%). The highest antibiotic resistance was observed in ampicillin (54.9%) and the lowest in amikacin (6.6%). Conclusion: Inappropriate treatment choices in UTIs are important in terms of complications that may occur in future. Therefore, healthcare centers should evaluate their own infectious agents and antibiotic susceptibility at certain intervals and determine appropriate empirical treatment choices. Empirically initiated treatments should be re-evaluated according to urine culture and sensitivity results.

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“…[2] Turkish pediatric data were strictly concordant with Eastern European data, and indicated similarly, serious rates of β-lactam resistance, fluoroquinolone, and sulfamethoxazole/trimethoprim resistance. [21][22][23][24][25] Our data were not divided into age groups but in general, compatible levels of AMR were observed.…”

Section: Discussionmentioning

confidence: 92%

Distribution of urinary Enterobacterales isolates and antibiotic resistance profiles: Three-year

Sığ

2023

Zeynep Kamil Med J

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Objective: Urinary tract infections (UTIs) are one the most frequent human infections. Increasing trend of antimicrobial resistance (AMR) and difficult-to-treat resistance cases are of serious concern. This study aimed to investigate the order of Enterobacterales urinary isolates and AMR profiles for 3 years in a tertiary hospital.Material and Methods: Clinical urinary cultures of patients obtained from January 2017 to December 2019 in Balıkesir Atatürk City Hospital were included in the study. Isolated Enterobacterales strains and their antibiotic susceptibilities were retrospectively evaluated. Antimicrobial susceptibility tests were performed by conventional and automated methods according to guidelines of The European Committee on Antimicrobial Susceptibility Testing.Results: Among a total of 9297 urine isolates, 78.5% were members of order Enterobacterales (n=7300). The majority of strains were isolated from intensive care units (n=3979; 54.5%). Most of the patients were female (62.9%) and 52.4% of the patients had an indwelling urinary catheter (catheter-associated UTIs). The carbapenem resistance was 13.6% in Klebsiella spp., followed by Morganella spp. (7.5%). Extended-spectrum β-lactamases (ESBLs) were detected most frequently also in Klebsiella spp. (over 50%), followed by Escherichia coli (over 30%) and Enterobacter spp. (over 30%). E. coli and Klebsiella spp. showed significant change in resistance to ceftazidime, while Proteus and Morganella spp. showed a change in resistance to cefepime and fluoroquinolone, additionally. Alterations in Amoxicillin and Clavulanic acid and cefepime resistance of Enterobacter and other rare species were also significant. Conclusion:Antibiotic consumption is strongly related to AMR and Türkiye seems to have a serious struggle with both antibiotic consumption and AMR. Local and/or national antimicrobial policies are effective in Türkiye, but further measures are required.

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A Retrospective Study on Urinary Tract Infection Agents Isolated from Children and Their Antibiotic Susceptibility

Cited by 5 publications

References 20 publications

Antibiotic Resistance Patterns in Pediatric Urinary Tract Infections: A Comparison Between 2013-2015 and 2019-2021 Pediatrik İdrar Yolu Enfeksiyonlarında Antibiyotik Direnç Paternleri: 2013-2015 ve 2019-2021 Arasında Bir Karşılaştırma

Antibiotic Resistance Patterns in Pediatric Urinary Tract Infections: A Comparison Between 2013-2015 and 2019-2021 Pediatrik İdrar Yolu Enfeksiyonlarında Antibiyotik Direnç Paternleri: 2013-2015 ve 2019-2021 Arasında Bir Karşılaştırma

Evaluation of Urinary Tract Infections in Pediatric Patients Admitted to the Emergency Department

Distribution of urinary Enterobacterales isolates and antibiotic resistance profiles: Three-year

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