A Retrospective Study on Efficacy and Safety of Guduchi Ghan Vati for Covid-19 Asymptomatic Patients

Kumar, Akhilesh; Prasad, Govind; Srivastav, Sanjay; Gautam, Vinay; Sharma, Neha

doi:10.1101/2020.07.23.20160424

Cited by 20 publications

(14 citation statements)

References 6 publications

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“…The reported efficacy of favipiravir, lopinavir/ritonavir and remdesivir was found to be either similar or inferior to the natural component from Guduchi. A previous retrospective study 21 also found that Guduchi Ghan Vati was effective in viral clearance and reducing hospital stay compared to standard care.…”

Section: Introductionmentioning

confidence: 81%

Efficacy and Safety of Guduchi Ghan Vati in the Management of Asymptomatic COVID-19 Infection: An Open Label Feasibility Study

Kumar

Prasad

Srivastav

et al. 2020

Preprint

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Background: Guduchi Ghan Vati (aqueous extract of Tinospora cordifolia) is an essential herbal plant in Indian traditional medicine (Ayurveda) that is well documented as an immunomodulator and antimicrobial agent. A recent in silico study found the therapeutic efficacy of Guduchi against SARS-CoV-2. Based on available evidence, we conducted a feasibility study of the safety and efficacy of Guduchi Ghan Vati in asymptomatic patients with covid-19. Patients and methods: An open label, feasibility trial was conducted on 46 patients in the hospital setting. A single-arm study with no control group and blinding was executed in Jodhpur, Rajasthan, India. All patients orally received 2 tablets (1000 mg) twice daily for 2 weeks. Clinical parameters were collected at baseline, day 3, day 7 and day 14. Patients were continuously monitored for side effects and adverse reactions during the study period. . Results: Out of 46 asymptomatic patients included in the study, 40 completed the 14-day follow-up period. None developed any Covid-19 symptoms after admission to the hospital. On day 3 post-treatment, viral clearance was reported in 16 (32.5%) patients. By the end of D-7, 38 (95%) patients had viral load disappearance. Follow-up at D-14 showed that all participants tested negative. Conclusion: In adult patients with asymptomatic Covid-19, Gudhuchi Ghan Vati could be effective. Randomized controlled trials with larger sample sizes in patients with Covid-19 are urgently needed to confirm the definite benefit with Ayurveda.

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Section: Introductionmentioning

confidence: 81%

Efficacy and Safety of Guduchi Ghan Vati in the Management of Asymptomatic COVID-19 Infection: An Open Label Feasibility Study

Kumar

Prasad

Srivastav

et al. 2020

Preprint

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“…As on July 14, 2020, 25% of the total 312 Indian clinical trials registered with CTRI involved Ayurveda, Yoga and Naturopathy [61]. While the results of some of these trials (such as [45,40]) indicate positive results for Ayurvedic formulations, most of these trials restrict to studying the impact of one formulation on the entire patient population without following the true Ayurvedic approach of personalized medicine. This severely limits the potential benefits that Ayurvedic and Yogic sciences have to offer for COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…They also offer specific guidelines about treatment and management of diseases that spread during Janapadoddhvansa. Based on this, many proposals to use Ayurveda for prophylaxis [20,21,22,23,24,25,26,27,28,29,30,31,32,33] as well as treatment of COVID-19 [34,22,35,36,37,23,24,25,27,38,28,39,40,41,42,43] have been published. See [44] (Related Works) for a detailed review on use of Yoga, Ayurveda and other systems of traditional medicine for treatment of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, there are reports of the use of Ayurveda for prophylaxis as well as treatment of In an open-label randomized controlled trial performed on COVID patients with mild to moderate symptoms in a tertiary care facility [45], the Ayurvedic medicines Dasamoolkaduthrayam Kashaya and Guluchyadi Kwatham (in tablet form) were administered as adjunct to the Standard of Care treatment to the treatment group; the Ayurvedic regime was observed to have fastened recovery in terms of reduction of symptoms (particularly breathlessness) as well as duration of stay in hospital. In another randomized controlled trail [40] that used the Ayurvedic medicine Guduchi Ghan Vati in addition to the standard treatment for asymptomatic COVID patients, all the patients in the intervention group continued to remain asymptomatic while 11.7% of those in the control group developed mild symptoms; moreover, significant differences between the two groups were observed in terms of duration of hospital stay as well as virologic clearance on days 7 and 14. The first COVID case treated entirely with Ayurveda has also been reported [46].…”

Section: Introductionmentioning

confidence: 99%

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Integrative Therapy based on Yoga, Ayurveda and Modern Western Medicine for Treatment of High-risk Cases of COVID-19: A Telemedicine-Based Case Series

Bentur¹,

Mishra²,

Kumar³

et al. 2021

Preprint

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Background: We report a telemedicine-based case-series of thirty high risk COVID-19 positive patients with co-morbidities such as Diabetes Mellitus (DM), Hypertension (HTN), Hypothyroidism, Ulcerative Colitis and Chronic Kidney Disease (CKD) or aged 60 and above (or possibly both), treated successfully using an Integrative Therapy plan based on Ayurveda, Yoga and Modern Western Medicine. The symptoms experienced by the patients included fever, body-ache, sore throat/throat pain, cough/running nose, headache, nasal/chest congestion, stomach problems (such as diarrhea, constipation), nausea, loss of taste, loss of smell, foul smell or taste, loss of appetite, weakness, gastric upset, respiratory trouble (such as breathlessness or high respiration rate) and anxiety. Two patients (both aged above 70) were asymptomatic and remained asymptomatic during the entire course of the treatment. Design: The reported cases have been categorized into YAS (patients taking Yoga and Ayurveda based treatment, with possibly western Supplements), YASP (patients taking Yoga and Ayurveda based treatment, with possibly western Supplements and Paracetamol), YAM (patients taking Yoga and Ayurveda based treatment, and Modern western medicine (MWM) as an adjunct), MYA (patients who first tried the Modern western medicines (in most of the cases mandated by the government) and later switched to Yoga and Ayurveda treatment. The last group has been further subdivided into subgroups – patients who developed new symptoms after the commencement of Yoga and Ayurveda-based treatment (MYA-S) and those who did not (MYS-NS). The YAS group had 4 patients, YASP had 6 patients, YAM had 6 and MYA had 14 patients (MYA-S having 7 and MYA-NS having 7). Case-Series Presentation: Ayurveda is a highly personalized system of medicine that considers the Prakruti (the Ayurvedic constitution) as well as Vikruti (the homeostatic imbalances) in treating the patients. Based on the patient's symptoms and co-morbidities, a personalized treatment plan including Ayurvedic medicines, Yoga protocol, dietary recommendations and lifestyle modifications was prescribed by a registered Ayurveda doctor and a Yoga consultant. More than half of the symptomatic patients started experiencing improvement within 5 days (90% within 9 days) from the start of the treatment. More than 60% of the symptomatic patients reported at least 90% recovery within 10 days (90% within 17 days) from the start of the treatment. Six patients, whose SpO2 level was observed to be at or below 95%, benefited from the practice of Makarasana and Shithilasana. None of the patients progressed to severe stage of illness. Many patients experienced improvement with respect to their comorbidities besides COVID-related symptoms. Some of them, after recovering from COVID, even sought consultation for long-term management of their comorbidities through Ayurveda and Yoga. Some patients got so convinced about the possibility of restoration of health through Yoga, that they adopted this practice into their lifestyle.Conclusions: The Integrative Therapy was found to be very effective in mitigating the symptoms of all the high-risk cases of COVID-19 patients with comorbidities who remained compliant to the treatment. Considering that approximately 32.8% of the patients with the comorbidities such as DM, HTN, COPD, cardiovascular disease, cerebrovascular disease, chronic kidney disease, Hepatitis B, malignancy, immunodeficiency progress to severe stage of illness, and assuming under the null hypothesis that a similar percentage of patients are expected to progress to a severe stage for the treatment population, the corresponding p-value (incorporating 23 symptomatic patients with one or more of the above comorbidities) turns out to be 1.07 x10^-4. Integrative Therapy based on classical texts of Ayurveda and Yoga from the East and emergency treatment of modern western medicine may offer a promising and scalable treatment option for COVID-19 patients. More studies including a suitably designed randomized controlled trial is needed to assess its efficacy.

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“…Several studies have been conducted to understand the COVID-19 pandemic and the conditions posed by it from the perspective of Ayurveda [77,46,68,22,76,101,60]. Based on these observations and the study of classical Ayurveda texts, several experts have proposed the use of Ayurveda for prophylactic [104,78,75,24,71,66,80,62,44,57,48,100,50,102] as well as therapeutic use [83,75,73,109,105,24,71,66,62,21,44,39,49,101,72,85] in COVID-19. Some studies have also suggested that lifestyle modifications, such as immunity boosting food, can aid in fighting the current situation [4].…”

Section: Related Workmentioning

confidence: 99%

Integrative Therapy based on Yoga and Ayurveda for Treatment of a High-risk Case of COVID-19/SARS-Cov-2 with Multiple Co-morbidities

Mishra¹,

Bentur²,

Thakral³

et al. 2020

Preprint

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Background: We report presumably the first known case of a high-risk COVID-19 positive patient with co-morbidities including Diabetes Mellitus (DM), Hypertension (HTN), Hypothyroidism and Chronic Kidney Disease (CKD), treated successfully using an Integrative Therapy plan based on Ayurveda and Yoga. Recently, some evidence has been emerging on the use of Ayurveda for treatment of COVID-19. The classical texts of Ayurvedic medicine such as Charaka Samhita and Sushruta Samhita contain the description of pandemics of similar proportions and describe them as Janapadoddhvansa meaning the destruction of communities, along with their causes and treatment.Case Presentation: The reported case, a 55 year old male confirmed (tested) patient of COVID-19, who first took modern western medicine (MWM) for 7 days before seeking the Integrative Therapy. The patient has comorbidities including DM, HTN, Hypothyroidism and CKD and had developed symptoms including fever (which was resolved by the time Integrative Therapy was started), sore throat, dry cough, body ache, weakness, bad taste and smell, and heaviness in abdomen. Based on the patient's symptoms and co-morbidities, a treatment plan including Ayurvedic medicines, Yoga protocol, dietary recommendations and lifestyle modifications was prescribed by a registered Ayurveda doctor and a Yoga consultant. The patient started experiencing improvement in all the symptoms within 2 days after starting the treatment; he reported approximately 75% relief from the symptoms after 5 days, and almost complete relief within 9 days. Also, the blood sugar levels (both Fasting Blood Sugar FBS, and Post Prandial Blood Sugar PPBS) exhibited significant improvement after 5 days, and came inside the normal range within 12 days. The patient was diagnosed free from infection on the basis of RT-PCR test on the 21st day (sample taken on the 19th day).Conclusions: The Integrative Therapy was found effective in curing the COVID-19 patient with above-mentioned co-morbidities. Moreover, a significant improvement in blood sugar levels (not under control with modern medicine) was also achieved. Integrative Therapy based on classical texts of Ayurveda and Yoga may offer a promising and scalable treatment option for COVID-19 patients. A suitably designed randomized controlled trial is needed to assess its efficacy.

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A Retrospective Study on Efficacy and Safety of Guduchi Ghan Vati for Covid-19 Asymptomatic Patients

Cited by 20 publications

References 6 publications

Efficacy and Safety of Guduchi Ghan Vati in the Management of Asymptomatic COVID-19 Infection: An Open Label Feasibility Study

Efficacy and Safety of Guduchi Ghan Vati in the Management of Asymptomatic COVID-19 Infection: An Open Label Feasibility Study

Integrative Therapy based on Yoga, Ayurveda and Modern Western Medicine for Treatment of High-risk Cases of COVID-19: A Telemedicine-Based Case Series

Integrative Therapy based on Yoga and Ayurveda for Treatment of a High-risk Case of COVID-19/SARS-Cov-2 with Multiple Co-morbidities

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