A Retrospective Study of the Medical Status on 63 African Hedgehogs (Atelerix albiventris) at the Taipei Zoo From 2003 to 2011

Pei-Chi, Hsieh; Yu, Jing; Wang, Lih-Chiann

doi:10.1053/j.jepm.2014.11.003

Cited by 31 publications

(34 citation statements)

References 25 publications

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“…BACKGROUND Spontaneous neoplasia is common in African Pygmy hedgehogs, with a reported disease prevalence of 30-60% (1)(2)(3)(4)(5)(6). The median age of affected animals ranges from 2.5 to 3.5 years, with most pet hedgehogs only living for 3 to 6 years (1,5,7).…”

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“…The median age of affected animals ranges from 2.5 to 3.5 years, with most pet hedgehogs only living for 3 to 6 years (1,5,7). Tumors most commonly arise from the skin, lymphoid tissue, and gastrointestinal, endocrine, and reproductive systems (1,2,5,6) and are usually malignant (up to 85%) (1). Lymphoma is the most common reported type of hematopoietic tumor, with a disease prevalence ranging from 2 to 9% (1,5,6).…”

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“…Tumors most commonly arise from the skin, lymphoid tissue, and gastrointestinal, endocrine, and reproductive systems (1,2,5,6) and are usually malignant (up to 85%) (1). Lymphoma is the most common reported type of hematopoietic tumor, with a disease prevalence ranging from 2 to 9% (1,5,6). In one study of 63 cases, lymphoma was the second most common reported tumor (6).…”

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“…Lymphoma is the most common reported type of hematopoietic tumor, with a disease prevalence ranging from 2 to 9% (1,5,6). In one study of 63 cases, lymphoma was the second most common reported tumor (6). In these reports, lymphoma usually involved multicentric peripheral lymph nodes, (1) with a few case reports of gastrointestinal, cutaneous and splenic forms (8)(9)(10)(11).…”

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Clinicopathologic Findings of Spontaneous Leukemia in 9 Pet African Hedgehogs (Atelerix Albiventris)

Koizumi¹,

Hernandez-Muguiro

Chu

et al. 2020

Front. Vet. Sci.

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Previous reports of leukemia in hedgehogs are limited. We describe clinicopathologic features of leukemia in 9 hedgehogs, including eosinophilic leukemia (n = 3) and acute leukemia/leukemic phase of lymphoma (n = 6). All 3 hedgehogs with eosinophilic leukemia were older than 2 years of age; in contrast, 4 of 6 cases of acute leukemia/lymphoma were <2 years old. Hedgehogs presented for non-specific clinical signs of anorexia and lethargy. On hematologic testing, hedgehogs with eosinophilic leukemia had a marked leukocytosis, consisting mostly of eosinophilic precursors with fewer mature eosinophils, whereas there were 43-97% immature cells (blasts) in the blood of hedgehogs with acute leukemia/lymphoma. Anemia (n = 6) and/or thrombocytopenia (n = 6) were concurrent findings. Increased liver enzyme activities (alanine aminotransferase, alkaline phosphatase) and hypoalbuminemia were the common findings on biochemical panels. All cases of eosinophilic leukemia and 4 cases of acute leukemia/lymphoma died shortly after diagnosis (median 7 days, range 0-41 days), whereas 2 cases of acute leukemia/lymphoma lived for 94 or 101 days. Postmortem examination in 5 cases (1 eosinophilic leukemia, 4 acute leukemia/lymphoma) showed bone marrow infiltrates, confirming eosinophilic leukemia and acute leukemia in 1 and 3 cases, and bone marrow necrosis in 1 animal with acute leukemia/lymphoma. Immunohistochemical staining of bone marrow sections confirmed a T-cell acute leukemia in 1 case. Several hedgehogs had concurrent carcinomas. Hedgehogs suffer from eosinophilic leukemia and acute leukemia/lymphoma. However, classification of acute leukemia by lineage was not possible due to lack of hedgehog cross-reactive or species-specific reagents.

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Clinicopathologic Findings of Spontaneous Leukemia in 9 Pet African Hedgehogs (Atelerix Albiventris)

Koizumi¹,

Hernandez-Muguiro

Chu

et al. 2020

Front. Vet. Sci.

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“…As a consequence, knowledge on health and disease aspects of this species has correspondingly increased, and neoplasia has been recognized as a leading cause of morbidity and mortality in captive individuals [33]. Table 1…”

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Spontaneous multicentric soft tissue sarcoma in a captive African pygmy hedgehog (<i>Atelerix albiventris</i>): case report and literature review

Díaz‐Delgado

Pool

Hoppes

et al. 2017

The Journal of Veterinary Medical Science

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This report describes the clinical, macroscopic, histopathological and immunohistochemical features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum. Histologic, histochemical and immunohistochemical analyses supported a diagnosis of multicentric poorly differentiated spindle cell sarcoma with fibrosarcomatous, storiform and myxoid foci. The high incidence of neoplasia and cross similarities renders the African hedgehog a suitable species for comparative pathology studies.

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Hedgehogs

2017

Pathology of Small Mammal Pets

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A Retrospective Study of the Medical Status on 63 African Hedgehogs (Atelerix albiventris) at the Taipei Zoo From 2003 to 2011

Cited by 31 publications

References 25 publications

Clinicopathologic Findings of Spontaneous Leukemia in 9 Pet African Hedgehogs (Atelerix Albiventris)

Clinicopathologic Findings of Spontaneous Leukemia in 9 Pet African Hedgehogs (Atelerix Albiventris)

Spontaneous multicentric soft tissue sarcoma in a captive African pygmy hedgehog (<i>Atelerix albiventris</i>): case report and literature review

Hedgehogs

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