A retrospective study of parotid gland tumors at a single institution

Abstract

The aim of the present study was to analyze the clinical characteristics, surgical treatments and clinical outcome of patients with parotid gland tumors and to compare the results with those cited in the literature. A retrospective study was conducted in 140 patients (male, n=77; female, n=63) with parotid gland tumors who underwent parotidectomy at Hokuto Hospital Department of Otolaryngology-Head and Neck Surgery (Obihiro, Japan) between April 2007 and December 2021. Of the 140 patients enrolled, 118 (84.3%) patients had benign tumors, including 63 (45%) patients with pleomorphic adenomas and 43 (30.7%) patients with Warthin tumors, and 22 patients (15.7%) had parotid carcinoma. Comparison of the three groups of patients with parotid gland tumors indicated that pack years as an indicator of smoking status were significantly higher in patients with Warthin tumors than in those with parotid carcinomas (P=0.011) or pleomorphic adenoma (P<0.001). Fine-needle aspiration cytology (FNAC) was non-diagnostic for only 6 (4.3%) of 140 patients. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of FNAC by both conventional smear and liquid-based cytology (LBC) for parotid carcinomas were 70, 99, 93.3, 94.4 and 82.9%, respectively. Among the 22 patients with parotid carcinoma, extended total/total and superficial parotidectomy were performed in 10 (45%) and 11 (50%) cases, respectively. Total and selective neck dissection of the area from level II to I, II and III were performed in 6 (24%) and 7 (32%) patients, respectively. Postoperative radiotherapy (50 Gy) was performed in 15 (68%) patients. The overall survival (OS) and disease-free survival (DFS) rates at 5 years were 51.5 and 76.4%, respectively. Univariate analysis revealed that age >65 years was significantly associated with poorer 5-year OS (P<0.001) and DFS (P<0.001). Multivariate analysis revealed that an age of more than 65 years combined with high-grade histologic malignancy was associated with worse DFS (P=0.02; hazard ratio, 3.628; 95% confidence interval, 1.283-9.514). In conclusion, the clinical characteristics and treatment outcomes of parotid gland tumors were consistent with the results of previous reports. Smoking may be closely related to the pathogenesis of Warthin tumors. LBC potentially provides improved accuracy in FNAC.

Construction and Application of a Nomogram for Predicting Benign and Malignant Parotid Tumors

“…We showed that age and sex are not independent risk factors for differentiating between benign and malignant parotid tumors. This finding was inconsistent with what has been reported previously 18,19,21 . One reason for the difference might be the small sample size, thus giving rise to the need for further analysis with a larger sample size.…”

“…This finding was inconsistent with what has been reported previously. 18,19,21 One reason for the difference might be the small sample size, thus giving rise to the need for further analysis with a larger sample size. To avoid overfitting, we divided parotid tumors, benign or malignant, into modeling and validation groups.…”

Một số đặc điểm lâm sàng, cận lâm sàng u lành tính tuyến mang tai tại Bệnh viện Trung ương Thái Nguyên từ năm 2020 đến năm 2023

“…Mật độ u chủ yếu là chắc 74,3%, ranh giới rõ 97,1%, di động hạn chế 60%. Những biểu hiện này phù hợp với hầu hết các nghiên cứu trước đó [8], [9].…”