A retrospective study of Ganoderma Lucidum Spore Powder for patients with epilepsy

Abstract

This study firstly investigated the feasibility effect and safety of Ganoderma Lucidum Spore Powder (GLSP) for treating patients with epilepsy.Eighteen eligible patients with epilepsy were included. They all received GLSP treatment for a total of 8 weeks. The primary outcome included weekly seizure frequency. The secondary outcomes consisted of each seizure episode, and quality of life, measured by the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), as well as the adverse events (AEs).After treatment, GLSP can significant reduce the weekly seizure frequency, compared with it before the treatment (P = .04). However, GLSP did not exert promising effect in each seizure episode (P = .13), and quality of life, measured by the QOLIE-31 scale (P = .11). Additionally, only minor AEs occurred during the treatment period.The results of this study showed that GLSP may be effective for reducing the weekly seizure frequency. Further studies are still needed to warrant this result.

Chinese Herbal Medicine for Treating Epilepsy

“…A retrospective study in 2018 included 18 patients with epilepsy who were treated with G. lucidum spore powder therapy three times per day for 8 weeks. The study revealed that the powder reduced the weekly seizure frequency and the severity of each seizure episode (Wang et al, 2018). Further studies are required to confirm its efficacy in treating human epilepsy.…”

“…The herb powder could reduce average weekly seizure frequency from 3.1 ± 0.8 to 2.4 ± 1.2, but it didn't show significant differences of duration of epilepsy and quality of life. The most common adverse effect is nausea, the second one is stomach discomfort, then the others are vomiting, dizziness, dry mouth, diarrhea, sore throat, and epistaxis in order (Wang et al, 2018).…”

Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study

“…Administration of hot water extracts from various herbs, including G. lucidum has been tested to relieve herpes zoster pain within a few days, and no patients developed post-herpetic neuralgia after more than one year of follow-up [344]. In 2018, a clinical study reported that weekly seizure frequency was reduced in patients with epilepsy after administration of G. lucidum spore powder [345]. In addition, G. lucidum also shows curative effects on depression in combination therapy [346].…”

Involvement of NFƙB and MAPK signaling pathways in the preventive effects of Ganoderma lucidum on the inflammation of BV-2 microglial cells induced by LPS

“…Certain mushrooms have not only nutritional value but also contain bioactive compounds with high medicinal properties. One such mushroom, the Ganoderma lucidum , is used across Asia as a nutraceutical and herbal remedy for many different ailments ( Ding et al, 2010 ; Batra et al, 2013 ; Collado Mateo et al, 2015 ; Wang et al, 2018a ; Geng et al, 2019 ). Ganoderma lucidum extract (GLE) has shown therapeutic benefits as an anti-diabetic agent, in breast cancer, and in inflammatory diseases such as colitis ( Martinez-Montemayor et al, 2011 ; Suarez-Arroyo et al, 2013 ; Liu et al, 2015 ; Barbieri et al, 2017 ; Geng et al, 2019 ; Liu and Tie, 2019 ; Yin et al, 2019 ).…”