A retrospective study of endophtalmitis rates comparing quinolone antibiotics

ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery

“…In this study, it was decided to investigate the effects of 2 drugs: intracameral cefuroxime 16,17 and topical levofloxacin. 8,[18][19][20][21][22][23] Cefuroxime was chosen for intracameral use as a consequence of the Swedish study of 32 000 patients, in which efficacy and safety were established. 16,17 Levofloxacin was chosen for topical use as a third-generation fluoroquinolone because it is well absorbed into the anterior chamber 8 and has enhanced antibacterial activity compared to ciprofloxacin and ofloxacin.…”

Preoperative disinfection of the conjunctival sac with antibiotics and iodine compounds: A prospective randomized multicenter study

“…Jensen et al 17 reported in their retrospective study that the endophthalmitis rate was signifi cantly lower in the postoperative topical ofl oxacin group than in the postoperative topical ciprofl oxacin group, indicating that newer and more potent antibiotics may reduce the rate of endophthalmitis. Considering the recent development of newer quinolones and other antibiotics, the search for appropriate antibiotics for prophylactic use is underway.…”

Intracameral cefuroxime injection at the end of cataract surgery to reduce the incidence of endophthalmitis: French study

“…4 Nevertheless, postoperative antibiotic eyedrops may reduce surface bacterial load until the incision is sealed; studies are still trying to determine the most effective postoperative antibiotic. 8,12 Subconjunctival antibiotic injection has been abandoned for pharmacokinetic reasons. [13][14][15][16][17][18] Systemic antibiotic prophylaxis is reserved for high-risk cases.…”