A Retrospective Brazilian Multicenter Study of Biopsies at the Periapical Area: Identification of Cases of Nonendodontic Periapical Lesions

Vieira, Carolina Clasen; Pappen, Fernanda Geraldo; Kirschnick, Laura Borges; Cademartori, Mariana Gonzalez; Nóbrega, Kaio Heide Sampaio; Couto, Aline Maria do; Schuch, Lauren Frenzel; Melo, Leonardo Araújo; Santos, Jean Nunes dos; Aguiar, Maria Cássia Ferreira de; Vasconcelos, Ana Carolina Uchôa

doi:10.1016/j.joen.2020.01.003

Cited by 11 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 1 ) and Kontogiannis et al . ( 5 ) but in contrast to other studies ( 2 , 3 , 7 ) in which females were predominant. The frequencies of cases occurring in the maxilla compared with those in the mandible did not differ much.…”

Section: Discussioncontrasting

confidence: 97%

“…Based on our study, the most common non-endodontic periapical lesion was dentigerous cyst followed by OKC. This data is in line with four previous studies showing that OKC was the most frequent lesion ( 1 - 3 , 5 ), and two studies ( 1 , 2 ) reporting that dentigerous cyst was the second and the third most common lesion. Three cases of malignancy were found in our study.…”

Section: Discussionsupporting

confidence: 93%

“…It constituted 32.48% of non-endodontic cases. The number of dentigerous cysts in this study was higher than three previous studies, ranging from 3.85 to 15.68% ( 1 , 2 , 5 ). The other two studies did not find dentigerous cyst in their series ( 3 , 6 ).…”

Section: Discussioncontrasting

confidence: 86%

“…( 1 ) and Vieira et al . ( 2 ), ameloblastoma was the most common benign tumor observed in our study accounting for 9.56% (15 cases) of non-endodontic periapical lesions. Ortega et al .…”

Section: Discussionmentioning

confidence: 48%

See 3 more Smart Citations

Non-endodontic periapical lesions clinically diagnosed as endodontic periapical lesions: A retrospective study over 15 years

Kosanwat¹,

Poomsawat²,

Kitisubkanchana³

2021

J Clin Exp Dent

View full text Add to dashboard Cite

Background This study aimed to provide the frequency and demographic data of non-endodontic periapical lesions clinically misdiagnosed as endodontic periapical lesions from a Southeast Asian population over a 15-year period. Material and Methods A retrospective study was conducted from departmental archives between 2005 and 2019. Cases clinically diagnosed as endodontic periapical lesions were retrieved. Then, cases with a histopathological diagnosis of non-endodontic periapical lesion were selected. Demographic data of non-endodontic periapical lesions were recorded. Radiographic features of cases with available radiographs were analyzed. Results Of 1,566 cases clinically diagnosed as endodontic periapical lesion, 157 cases received a histopathological diagnosis of non-endodontic origin. Eighteen different histopathological diagnoses were identified. The most frequent lesion was dentigerous cyst (n= 51, 32.48%) followed by odontogenic keratocyst (n=31, 19.75%), nasopalatine duct cyst (n=18, 11.46%) and ameloblastoma (n=15, 9.56%). Three cases of malignant tumors, including adenoid cystic carcinoma, mucoepidermoid carcinoma, and metastatic papillary thyroid carcinoma were observed. Conclusions Non-endodontic periapical lesions constituted 10.03% of cases clinically diagnosed as endodontic periapical lesions. Histopathological examinations of non-endodontic periapical lesions revealed a variety of lesions ranging from foreign body reaction, cysts, fibro-osseous lesions, benign tumors and primary or metastatic malignant tumors. Of clinical significance is that some non-endodontic periapical lesions had different treatment modalities and prognoses compared with endodontic lesions. Therefore, dentists must be aware that periapical radiolucent lesions are not always a consequence of pulpal necrosis. Key words: Ameloblastoma, dentigerous cyst, endodontic periapical lesions, non-endodontic periapical lesions, odontogenic keratocyst.

show abstract

Section: Discussioncontrasting

confidence: 97%

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 86%

“…( 1 ) and Vieira et al . ( 2 ), ameloblastoma was the most common benign tumor observed in our study accounting for 9.56% (15 cases) of non-endodontic periapical lesions. Ortega et al .…”

Section: Discussionmentioning

confidence: 48%

See 2 more Smart Citations

Non-endodontic periapical lesions clinically diagnosed as endodontic periapical lesions: A retrospective study over 15 years

Kosanwat¹,

Poomsawat²,

Kitisubkanchana³

2021

J Clin Exp Dent

View full text Add to dashboard Cite

show abstract

“…22 Second, although the diagnosis of intraosseous lesions located close to the root of the teeth is a major challenge for the provider during clinical and image examination, a set of differential diagnoses of inflammatory periradicular conditions should have been considered. 23,24 In this context, since many lesions of pediatric patients are asymptomatic and discovered incidentally, other lesions may grow rapidly and be very destructive, 19 as observed in the current study. Thus, pediatric dentists and orthodontists should also be aware of the possibility of the occurrence of a CGCG of the jaws in adolescents.…”

Section: Discussionsupporting

confidence: 50%

Central giant cell granuloma of the maxilla: Long‐term follow‐up of a patient treated with an adjuvant corticosteroid

Arruda

Martins

Abreu

et al. 2021

Special Care in Dentistry

View full text Add to dashboard Cite

Background: Central giant cell granuloma (CGCG) is one of the most intriguing lesions of the jaws and its nature has not yet been fully elucidated. Clinically, some CGCG behave more aggressively, while others have an indolent course.In cases of aggressive CGCG of the maxilla, effective personalized therapies are worth understanding. Case report:We report here a challenging case of aggressive CGCG in a 15-yearold girl which was misdiagnosed as an endodontic lesion. Radiographically, a large osteolytic lesion involving the hard palate from the central incisor to the second premolar, extending into the nasal cavity, with loss of the lamina dura and cortical resorption was observed. The lesion expanded aggressively after extensive curettage. With possible mutilation and defects due to a more radical approach to the lesion, treatment with systemic prednisone and intralesional triamcinolone hexacetonide associated with a calcitonin nasal spray was instituted. The decision in favor of this therapeutic strategy was made after careful immunohistochemical analysis of calcitonin and glucocorticoid receptors. The H-score for the staining of glucocorticoid and calcitonin receptors in multinucleated giant cells was 222 and 153.6, respectively. The lesion reduced in size, and no adverse effects associated with medications were observed. Another curettage was performed, and only fibrous connective tissue was found. The patient is in follow-up for 11 years without evidence of recurrence. Conclusion: Pharmacological agents hold clinical promise in cases of aggressive CGCG affecting the maxilla of pediatric patients. Investigating the expression of calcitonin and glucocorticoid receptors in order to plan treatment is very helpful in the decision to manage aggressive CGCG.

show abstract

Malignant Lesions Mimicking Endodontic Pathoses Lesion: A Systematic Review

Schuch

Vieira

Vasconcelos

2021

Journal of Endodontics

View full text Add to dashboard Cite

A Retrospective Brazilian Multicenter Study of Biopsies at the Periapical Area: Identification of Cases of Nonendodontic Periapical Lesions

Cited by 11 publications

References 23 publications

Non-endodontic periapical lesions clinically diagnosed as endodontic periapical lesions: A retrospective study over 15 years

Non-endodontic periapical lesions clinically diagnosed as endodontic periapical lesions: A retrospective study over 15 years

Central giant cell granuloma of the maxilla: Long‐term follow‐up of a patient treated with an adjuvant corticosteroid

Malignant Lesions Mimicking Endodontic Pathoses Lesion: A Systematic Review

Contact Info

Product

Resources

About