Malignant Lesions Mimicking Endodontic Pathoses Lesion: A Systematic Review

Primary Extra Nodal Diffuse Large B-Cell Lymphoma of the Maxillary Sinus with Symptoms of Acute Pulpitis

“…Yet, the persistent symptoms (pain, unhealed extraction socket) raised our suspicion of pathologies of nonodontogenic sources in the maxillary sinus and led to appropriate workup. It is worthy of the clinician's attention that although periapical lesions are the most commonly encountered radiolucency in the jaws, about 0.65% to 4.22% of clinical cases were misdiagnosed as endodontic periapical pathosis before histopathological diagnoses were made [ 10 ]. In this case, further morphological examination showed that large B lymphoma cells were arranged in a spreading pattern with large nuclear and partially or completely covered normal lymph nodes or extranode structures.…”

Malignant tumours mimicking periapical lesions: A report of three cases and literature review

“…The cases involving OSJ other symptoms that were useful for suspecting a malignant lesion, such as swelling, persistent pain and paraesthesia. Pain, tooth mobility and asymmetry (26) and numbness of the lip (9,25,26,27,28,29,30,31), have been reported as symptoms of OSJ in the literature. The widening of the entire periodontal ligament space (26,27), as observed in our cases, is also usually reported.…”

“…Malignant neoplasms of the salivary glands account for 25% of cases of lesions mimicking periapical lesions (9), with 5%–10% being the mucoepidermoid carcinoma type (10). Salivary gland neoplasms arising within the jaws as primary central bony lesions comprise 2%–3% of all mucoepidermoid carcinomas reported (4), and they occur about three times more frequently in the mandible than in the maxilla (5) and twice as often in females than in males (4,11).…”

“…Schuch et al. (9) described the clinical and radiological features of 60 cases of malignant tumours mimicking periapical lesions. The most prevalent clinical signs were pain symptoms (90%) and tooth mobility (52.17%).…”

Clinical and medico‐legal considerations in endodontics

“…Patients might experience persistent pain following treatment, which might or might not be related to their presenting symptoms, as it is not uncommon for patients to have non‐odontogenic or atypical pain following endodontic treatment 74 . Some patients presenting with suspected endodontic pain might actually be presenting with other conditions, ranging anywhere from the common and relatively mild dentine hypersensitivity, to cardiac ischaemia, 75 orofacial pain 74 or neoplasia 76 …”