A retrospective analysis of the clinicopathological characteristics of large cell carcinoma of the lung

Abstract

The aim of the present study was to analyze and summarize the clinicopathological characteristics of large-cell lung carcinoma (LCLC) of the lung, in order to improve the definite diagnosis rate of LCLC. Clinicopathological data of 174 patients with LCLC, confirmed pathologically, were retrospectively reviewed. The 174 cases of LCLC accounted for 5.7% of the total lung cancer cases during the corresponding time period at the Affiliated Cancer Hospital of Tianjin Medical University (Tianjin, China), among which there were 131 males and 43 females with an average age of 61.4 years. The postoperative pathological diagnosis of the 174 cases showed 80 cases of classic LCLC, 64 cases of large cell neuroendocrine carcinoma (LCNEC), six cases of combined LCNEC, 19 cases of basaloid carcinoma, three cases of clear cell carcinoma and two cases of lymphoepithelioma-like carcinoma. Of the total 174 LCLC cases, 96 patients exhibited lymph node metastasis. LCLC is a highly aggressive malignancy with a high tendency of invasion and metastasis, although the incidence rate is low. A definite diagnosis of LCLC primarily relies on the pathological diagnosis. Each subtype of LCLC has its own pathomorphological and immunohistochemical characteristics.

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways

“…Lung cancer is a disease that severely threatens human health and its incidence shows yearly increases (1). Lung cancer accounts for the highest number of cancer-associated mortalities in women and men worldwide (2).…”

Clinicopathological features and prognosis of primary pulmonary lymphoepithelioma-like carcinoma

“…Lymphoepithelioma-like carcinoma (LELC) is one of the rare histological types of lung cancer, classified into one subtype of large cell carcinoma (LCC) (1), with the incidence of 1.15% to 5.90% of total LCC (2,3). It was reported that LELC was commonly found in the relatively young non-smoking Asian population, without a distinctive difference with respect to gender; more than half the patients were at an early stage (stage I and II) and were treated by complete resection (4).…”

Peer Review #1 of "Clinicopathological characteristics and prognosis of pulmonary large cell neuroendocrine carcinoma aged ≥65 years (v0.2)"

“…Pulmonary LCNEC is biologically aggressive, with poor prognosis (Fasano et al 2015). The 5-year OS rate for LCNEC after resection has been reported to range from 13 to 57% (Liang et al 2015;Varlotto et al 2011;Younossian et al 2002). Similarly, in our study, we found that the 5-year OS rate in the older patient group and the younger group as 13.47% and 20.51%, respectively, which are consistent with previous studies.…”