A retrospective analysis and literature review of neoplastic appendiceal mucinous lesions

Abstract

Background At present, the term mucocele is outdated, and mucinous appendiceal neoplasm is preferred. Mucinous appendiceal neoplasm is an uncommon pathology that occurs predominantly in middle-aged women. Its classification and management have been the subject of debate in recent decades. The aim of this study was to analyse the incidence, clinical management and survival of these tumours diagnosed in our centre in the last 10 years. Methods This was a retrospective observational study of patients with a diagnosis of appendiceal neoplasms between 2009 and 2018 in our centre. Variables such as sex, age, tumour type, clinical status, diagnosis, treatment and survival were collected. All data were analysed using the statistical program IBM SPSS Statistic® version 25. Results Twenty-nine patients with a diagnosis of appendiceal neoplasm were identified, and 24 corresponded to neoplastic appendiceal mucinous lesions (85.7%). The average age was 59.7 ± 17.6 years. Most patients were women (15 cases; 62.5%). Most of them presented with chronic abdominal pain (37.5%), and the diagnosis was performed by computed tomography (CT) (50%). The treatment was surgical in all cases. The surgical technique depended on the findings and histology of the tumour. Conclusion Mucinous appendiceal neoplasms are an uncommon entity, and their pathological classification and management have recently changed.

Appendiceal mucocele presenting as a leading point in ileocolic intussusceptions: “Case report”

“…Appendiceal mucoceles are rare tumors commonly seen in women of 50 to 60 years of age [4] . They are encountered in 0.2–0.7 % of appendectomy specimens [1] .…”

“…The term “mucocele” is recently discouraged by some authors for more specific pathological terms, though it is still in use by radiologists and surgeons [3] . Appendiceal mucocele is more common in women and age of occurrence ranges from 50 to 60 years [4] .…”

Mucocele apendicular

“…Es el método de elección para la valoración del mucocele, inclusive para identificar posibles complicaciones asociadas (3,7). Un aumento mayor a 15 mm en su tamaño es característico de mucocele apendicular con 83 % de sensibilidad y 92% de especificidad (8). El tamaño del mucocele es un factor importante que valorar durante el TAC, debido a que si este es menor a 2cm es por lo general de origen benigno, mientras que si llega a medir 6cm o más tendrá mayor asociación a cistadenocarcinoma y mayor riesgo de perforación (2).…”

“…la medición de CA 19-9 y CA 125 también pueden ser útiles. Hasta 67% de los pacientes cursan con marcadores elevados (8).…”

Volvulus of the Appendix

“…This may require chemotherapy or palliative surgery and ultimately confers a poorer prognosis. 3 Keywords: Volvulus; Appendicitis; Mucinous Neoplasm.…”