A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL‐INCA)

González, Hector M.; Tarraf, Wassim; Fornage, Myriam; González, Kevin A.; Chai, Albert; Youngblood, Marston; Abreu, María de los Ángeles; Zeng, Donglin; Thomas, Sonia; Talavera, Gregory A.; Gallo, Linda C.; Kaplan, Robert C.; Daviglus, Martha L.; Schneiderman, Neil

doi:10.1016/j.jalz.2019.08.192

Cited by 61 publications

(89 citation statements)

References 40 publications

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“…We analyzed two binary cognitive variables that were previously constructed 30 based on cognitive tests and self‐report: significant cognitive decline, and MCI. Cognitive decline measures the cognitive decline between HCHS/SOL visit 1 and the SOL‐INCA exam, based on a latent factor model taking into account cognitive test scores.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive decline measures the cognitive decline between HCHS/SOL visit 1 and the SOL‐INCA exam, based on a latent factor model taking into account cognitive test scores. Individuals were classified as meeting significant cognitive decline criteria if they had a change in global cognitive performance between the two exams that exceeded –0.055 standard deviation (SD) yearly 30 …”

Section: Methodsmentioning

confidence: 99%

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APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)

Granot‐Hershkovitz

Tarraf

Kurniansyah

et al. 2020

Alzheimer's & Dementia

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Introduction Apolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry‐specific genetic effects. Methods We investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations. Results APOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P‐value = 0.03), with the strongest association in Cubans (OR = 1.46, P‐value = 0.007). APOE‐ε2 was associated with decreased risk of MCI (OR = 0.37, P‐value = 0.04) in Puerto Ricans. Amerindian genetic ancestry was found to protect from the risk conferred by APOE ε4 on significant cognitive decline. Discussion Results suggest that APOE alleles' effects on cognitive outcomes differ across six Latino backgrounds and are modified by continental genetic ancestry.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)

Granot‐Hershkovitz

Tarraf

Kurniansyah

et al. 2020

Alzheimer's & Dementia

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“…1 The large-scale cohorts and biobanks will provide the basis for a comprehensive solution to accelerate the advancements and fill scientific gaps in this field. 8 To date, several longitudinal studies, cohorts, biobanks, and consortia have been established for dementia research globally, such as Campaign to Prevent Alzheimer's Disease 2020 (PAD2020), 9 the Alzheimer's Disease Neuroimaging Initiative (ADNI), 10 the Atherosclerosis Risk in Communities (ARIC) Study, 11 the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA), 12 and the Three-City Study (3C Study). 13 Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is important to advance Chinese Taizhou Imaging Study dementia research by establishing China's own well-characterized cohorts, such as TIS and the Shanghai Aging Study (SAS).…”

Section: Why Are Cohort Studies Needed For Dementia Prevention?mentioning

confidence: 99%

Lifestyle, multi‐omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study

Jiang

Cui

Tian

et al. 2020

Alzheimer's & Dementia

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China has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under-researched. Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is crucial to build appropriate infrastructure for long-term longitudinal studies to advance Chinese cognitive aging and dementia research. We initiated a community-based prospective cohort-the Taizhou Imaging Study (TIS)-to accelerate the understanding of dementia and cerebrovascular diseases in Chinese. This article presents the rationale, aims, study design, and organization of TIS. In addition, we described some examples of the types of studies such a resource might support. The TIS provides a new framework for facilitating Chinese dementia research, encompassing invaluable resources including detailed epidemiological, sociocultural, neuroimaging, and omics data.

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“…The SOL-INCA is an ancillary study to the HCHS/SOL (González et al 2019a), designed to study the development of AD and related dementia (ADRD) in U.S. Hispanics/Latinos. The average age at the SOL-INCA exam was 62, allowing for assessment of MCI, but not yet of ADRD, with MCI being defined using the National Institute on Aging– Alzheimer’s Association criteria for MCI syndromes (Albert et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Polygenic Risk Scores for Alzheimer’s Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos – Investigation of Neurocognitive Aging

Sofer

Kurniansyah

Granot‐Hershkovitz

et al. 2021

Preprint

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IntroductionPolygenic Risk Score (PRS) are powerful summaries of genetic risk alleles that can potentially be used to predict disease outcomes and guide treatment decisions. Hispanics/Latinos suffer from higher rates of Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI) compared to non-Hispanic Whites, yet the strongest known genetic risk factor for AD, APOE-ϵ4 allele, has weak association with AD in Hispanics/Latinos. We evaluated PRS constructed based on Genome-Wide Association Studies (GWAS) of AD in predicting MCI in Hispanics/Latinos when accounting for APOE alleles and variants.MethodsWe used summary statistics from four GWAS of AD to construct PRS that predict MCI in 4,189 diverse Hispanics/Latinos (mean age 63 years, 47% males) from the Study of Latinos-Investigation of Neurocognitive Aging. We assessed the PRS associations with MCI in the combined set of people and in groups defined by genetic ancestry and Hispanic/Latino background, and when including and excluding single nucleotide polymorphisms (SNPs) from the APOE gene region.ResultsA PRS constructed based on GWAS of AD in the FINNGEN Biobank was associated with MCI (OR = 1.34, 95% CI [1.15, 1.55]), and its association was mostly driven by 158 APOE region SNPs. A PRS constructed based on a multi-ethnic AD GWAS was associated with MCI (OR=1.22, 95% CI [1.08, 1.37]) without including any APOE region SNPs. APOE-ϵ4 and APOE-ϵ2 alleles were not associated with MCI.DiscussionA combination of APOE region SNPs is associated with MCI in Hispanics/Latinos despite APOE-ϵ4 and APOE-ϵ2 alleles not being associated with MCI.

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A research framework for cognitive aging and Alzheimer's disease among diverse US Latinos: Design and implementation of the Hispanic Community Health Study/Study of Latinos—Investigation of Neurocognitive Aging (SOL‐INCA)

Cited by 61 publications

References 40 publications

APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)

APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)

Lifestyle, multi‐omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study

Polygenic Risk Scores for Alzheimer’s Disease and Mild Cognitive Impairment in Hispanics/Latinos in the U.S: The Study of Latinos – Investigation of Neurocognitive Aging

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