Lifestyle, multi‐omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study

Abstract

China has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under-researched. Given the differences in genetic, demographic, sociocultural, lifestyle, and health profiles among Chinese and other ethnic/racial groups, it is crucial to build appropriate infrastructure for long-term longitudinal studies to advance Chinese cognitive aging and dementia research. We initiated a community-based prospective cohort-the Taizhou Imaging Study (TIS)-to accelerate the understanding of dementia and cerebrovascular diseases in Chinese. This article presents the rationale, aims, study design, and organization of TIS. In addition, we described some examples of the types of studies such a resource might support. The TIS provides a new framework for facilitating Chinese dementia research, encompassing invaluable resources including detailed epidemiological, sociocultural, neuroimaging, and omics data.

Multi-kingdom microbiota analyses identify bacterial–fungal interactions and biomarkers of colorectal cancer across cohorts

“…1809191-7). Healthy controls (86 individuals) with a similar age and sex ratio were selected from the Taizhou Imaging Study (TIS) [43][44][45] , which is an ongoing longitudinal study intended to explore the aetiology and risk factors of cerebrovascular disease and dementia in three villages that previously showed high response rates from Taixing, China. TIS individuals without physician-diagnosed dementia, stroke, cancer, cardiovascular disease, psychiatric disorders or other serious illnesses were recruited.…”

MRI‐Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure

“…Participants in the present study were also participants in the Phase Ι study of the Taizhou Imaging Study (TIS). As reported previously, 18 the eligibility criteria for TIS were as follows: between 55 and 65 years of age; of Han Chinese ethnicity; residents of Taizhou for the past 10 years; having local Taizhou residency more than 9 months per year; being able to walk and communicate normally and independently; being able to provide information by self‐reporting; and being able to participate in physical examinations. Exclusion criteria were as follows: history of stroke or cancer; a history of clinically diagnosed neurological or psychiatric disorders; signs of abnormalities by neurological examination; and major visual or hearing impairment.…”

The Effects of Brain Magnetic Resonance Imaging Indices in the Association of Olfactory Identification and Cognition in Chinese Older Adults

“…A neuropsychological test battery was used to assess participants' cognitive function, as described previously (Jiang et al, 2021). Briefly, several neuropsychological tests generated from developed countries, which covered global cognition, memory, executive function and attention, visuospatial function, and language, were adapted, normalized, and validated to suit Chinese culture (Jiang et al, 2021). The neuropsychological tests used in this study have been validated in Chinese population and normative data has been published previously (Ding et al, 2015) (1) to (3) and ( 5)-( 8) were used for participants with ≥6 years of formal education (participants who completed primary education), while (1), (2), and (4)-( 8) were used for participants with <6 years of education (Cui et al, 2020;Jiang et al, 2021).…”

“…Briefly, several neuropsychological tests generated from developed countries, which covered global cognition, memory, executive function and attention, visuospatial function, and language, were adapted, normalized, and validated to suit Chinese culture (Jiang et al, 2021). The neuropsychological tests used in this study have been validated in Chinese population and normative data has been published previously (Ding et al, 2015) (1) to (3) and ( 5)-( 8) were used for participants with ≥6 years of formal education (participants who completed primary education), while (1), (2), and (4)-( 8) were used for participants with <6 years of education (Cui et al, 2020;Jiang et al, 2021). Among them, The Auditory Verbal Learning Test was adapted from California Verbal Learning Test and The Modified Fuld Object Memory Evaluation was adapted from the Fuld Object Memory Evaluation (Ding et al, 2015).…”