A Reliable Screening Protocol for Thalassemia and Hemoglobinopathies in Pregnancy

Sanchaisuriya, Kanokwan; Fucharoen, Supan; Fucharoen, Goonnapa; Ratanasiri, Thawalwong; Sanchaisuriya, Pattara; Changtrakul, Yossombat; Ukosanakarn, Uthai; Ussawaphark, Wichai; Schelp, Frank Peter

doi:10.1309/fuf9-evgq-24v1-pktp

Cited by 14 publications

(30 citation statements)

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“…DCIP. Most of the research were thalassemia ε and thalassemia α, β thalassemia whereas only about 3% [15]. In this study, and several other research when OTOFT negative result should be examined to find thalassemia ε, if it was positive be required to confirm these with other examinations including electrophoresis because there more false negatif.…”

Section: Resultsmentioning

confidence: 73%

“…When compared with the average overall number of erythrocytes on examination OTOFT positive slightly increase, at 4.13.106 / mm 3 . while results Sanchaisuriya research normal population of pregnant women at 4.1 ± 0.4 106 / mm 3 [15].…”

Section: Resultsmentioning

confidence: 85%

“…The group anemia with positive results in OTOFT method 8 samples (3.6 %), whereas that does not suffer from anemia as many as 9 samples (4.1%). Research Sanchaisuriya et al, average gain in pregnant women of 12.2 ± 1.1 g / dL that higher than limit normal women with pregnancy (11.0 g/dL) [15].…”

Section: Resultsmentioning

confidence: 92%

“…Likewise with the average value of 28.2 ± 2.59 pg MCH was still above the normal value of 27 pg. Sanchaisuriya get an average MCV and MCH in pregnant women respectively 87.9 ± 5.0 fl and 29.9 ± 2.1 pg [15].…”

Section: Resultsmentioning

confidence: 93%

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MCV-MCH Value and One Tube Osmotic Fragility Test (OTOFT) Method for Thalassemia Trait Detection in Pregnancies

Pribadi¹,

Mose²,

Effendi³

2016

Med-Science

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Section: Resultsmentioning

confidence: 73%

Section: Resultsmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 93%

See 2 more Smart Citations

MCV-MCH Value and One Tube Osmotic Fragility Test (OTOFT) Method for Thalassemia Trait Detection in Pregnancies

Pribadi¹,

Mose²,

Effendi³

2016

Med-Science

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“…The false negetive result with MCV and MCH for screening is unacceptable especially in a population where there is significant high prevalence of Hb E 22 There is no definite data regarding carriers of hereditary disorder existing in Bangladesh. A conservative World Health report has estimated that 3 percent (3.6 million) carriers of ß thalassemia and 4 percent(4.8 million) are carriers of Hb E in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Significance of Haemogram Parameters and RBC Indices in Haemoglobin E Trait

Khondaker¹,

Ahmed²,

Amin³

2017

Anwer Khan Mod Med Coll J

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Background: Hemoglobin E disease are the most common structural haemoglobinopathies, reaching its highest frequency in South East Asia and also prevalent in Bangladesh. There are very few data for effective screening of HB E trait. The aim of the study was to analyze hematological profile and RBC indices as a marker of screening for Hb E trait. Methodology:A cross sectional observational study was conducted among 150 subjects at Dhaka Shishu (Children) Hospital from December 2008 to November 2009. On the basis of Hb electrophoresis, all subjects were divided into three groups. Group I comprised of 50 subjects with Hb E trait, group II comprised 51 subjects with ß thalassemia trait and Group III comprised of 49 normal subjects. Result of RBC indices and blood count were compared between Hb E trait and normal study population. Results:In group I the mean age was 29.53 years and the age range was 2-47 years. In group II the mean age was 30.31 years and the range was 1-55 years. In group III the mean age was 21.81 years and the range was 1-52 years. The present study revealed the mean±SD haemoglobin level (g/dl) in group I (E trait) and group III (normal subjects) were 11.76±1.91 and 10.77±1.4 respectively. Statistically no significant difference was found between these 2 groups (P>.05). The mean corpuscular volume (MCV) in mean±SD in group I and group III were 72.89±12.24 fl and 77.35±10.27 fl respectively. No statistical significance was found as P>0.05. The mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) in group I were 24.84±2.71pg & 32.97±2.27 g/dl and in group III were 28.28±2.71 pg & 32.97±2.38 g/dl respectively. There were no significant difference between group I and III regarding MCH and MCHC.The mean RBC count in E trait and normal subject group were 5.01±71 million/cmm and 4.61±0.65 million/cmm respectively. There was no significant difference was found P>0.05. Mean red cell distribution width (RDW) in group I and III were 14.32 ±2.34 and 14.83±1.28 without any statistical difference (P>0.05) Conclusion: In our study there were no diagnostic significance of Blood count and RBC Indices for detection of Hb E trait. More study should be conducted to find out reliable marker of screening for Hb E carrier.Key Words: Hb E Disease, Hb E Trait. ß Thalassemia trait ABSTRACT including South East Asia². The hereditary disorder of haemoglobin usually present as either a reduced rate of production of one or more of the globin chain (thalassaemia) nor those in which there is

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A comparison of the accuracy of the corpuscular fragility and mean corpuscular volume tests for the alpha‐thalassemia 1 and beta‐thalassemia traits

Sirichotiyakul

Wanapirak

Srisupundit

et al. 2009

Intl J Gynecology & Obste

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A Reliable Screening Protocol for Thalassemia and Hemoglobinopathies in Pregnancy

Cited by 14 publications

References 0 publications

MCV-MCH Value and One Tube Osmotic Fragility Test (OTOFT) Method for Thalassemia Trait Detection in Pregnancies

MCV-MCH Value and One Tube Osmotic Fragility Test (OTOFT) Method for Thalassemia Trait Detection in Pregnancies

Diagnostic Significance of Haemogram Parameters and RBC Indices in Haemoglobin E Trait

A comparison of the accuracy of the corpuscular fragility and mean corpuscular volume tests for the alpha‐thalassemia 1 and beta‐thalassemia traits

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