A release-on-demand wireless CMOS drug delivery SoC based on electrothermal activation technique

Yang, Yao‐Joe; Huang, Yu-Jie; Liao, Hsin-Hung; Wang, Tao; Huang, Po‐Cheng; Lin, Chunn-Yenn; Wang, Yao-Hong; Lu, Shey‐Shi

doi:10.1109/isscc.2009.4977421

Cited by 19 publications

(4 citation statements)

References 7 publications

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“…To enhance islet transplantation, encapsulation strategies were used that promote angiogenesis, oxygen delivery, and immune protection, which eliminate immunosuppression and enhance long-term survival and function. A new implant delivers drugs precisely using micro-and nano-technologies; a CMOS SoC device combines wireless control, actuation, and drug delivery [46]. This device can be implanted via minimally invasive surgery to treat cancer and heart attacks.…”

Section: Research Survey For Exploring the Role Of Iot In Revolutioni...mentioning

confidence: 99%

Advances and Challenges in IoT-Based Smart Drug Delivery Systems: A Comprehensive Review

Raikar,

Kumar,

Raikar

et al. 2023

ASI

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In the current era of technology, the internet of things (IoT) plays a vital role in smart drug delivery systems. It is an emerging field that offers promising solutions for improving the efficacy, safety, and patient compliance of drug therapies. IoT-based drug delivery systems leverage advanced devices, sophisticated sensors, and smart tools to monitor and analyse the health matrices of the patient in real-time, allowing for personalised and targeted drug delivery. This technology is implemented through various types of devices, including wearable and implantable devices such as infusion pumps, smart pens, inhalers, and auto-injectors. However, the development and implementation of IoT-based drug delivery systems pose several challenges, such as ensuring data security and privacy, regulatory compliance, compatibility, and reliability. In this paper, the latest research on smart wearable devices and its analysis are addressed. It also focuses on the challenges of ensuring the safe and efficient use of this technology in healthcare applications.

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Section: Research Survey For Exploring the Role Of Iot In Revolutioni...mentioning

confidence: 99%

Advances and Challenges in IoT-Based Smart Drug Delivery Systems: A Comprehensive Review

Raikar,

Kumar,

Raikar

et al. 2023

ASI

View full text Add to dashboard Cite

show abstract

“…Fig. 1 shows a conceptual view of this communication and wireless body sensor network (WBSN) applications [1]- [5]. In WBSN, the distance between the sensor node and central node is less than 3 m. For these distances, the power needed for the transmitter should be about 1 mW.…”

Section: Introductionmentioning

confidence: 99%

Analysis and Design of Colpitts Oscillator for Short-range WSN

Yousefi

2016

International Journal of Electronics and Telecommunications

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In this paper, analysis and design of colpitts oscillator with ability to transmit data at low output power with application in short-range wireless sensor networks such as MICS is described. Reducing the area required to implement the transmitter, on-chip implementation and appropriate energy efficiency are the advantages of this structure that makes it suitable for the design of short-range transmitter in biomedical applications. The proposed OOK transmitter works at 405 MHz with 10 Mbps data rate. Output power and total power consumption are 25 µW and 726 µW, respectively. Energy efficiency is 72.6 pJ/bit. The transmitter has been designed and simulated in 0.18 µm CMOS technology.

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“…For implantable drugdelivery devices, for example, this ability may be utilized to enable a controlled and selective delivery of different types of drugs at specific mixtures for various clinical applications including pain control methods [1] as well as diabetic [2] and glaucoma treatments [3]. Micro-electro-mechanical systems (MEMS) technologies have been applied to develop wireless drug-delivery devices [4][5][6][7], which implement drug release by wirelessly triggering the breakage of sealing membranes of drug reservoirs. One major approach in the wireless control of microactuators involves utilizing active circuitry, often powered by batteries [4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Micro-electro-mechanical systems (MEMS) technologies have been applied to develop wireless drug-delivery devices [4][5][6][7], which implement drug release by wirelessly triggering the breakage of sealing membranes of drug reservoirs. One major approach in the wireless control of microactuators involves utilizing active circuitry, often powered by batteries [4][5][6][7][8][9][10][11]. In this approach, however, the devices tend to have relatively large overall sizes with limited longevity, and these constraints deteriorate as the number of actuators increases [11].…”

Section: Introductionmentioning

confidence: 99%

Wireless microfluidic control with integrated shape-memory-alloy actuators operated by field frequency modulation

Ali

Takahata

2011

J. Micromech. Microeng.

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This paper reports wireless microfluidic control enabled by the selective operation of multiple bulk-micromachined shape-memory-alloy actuators using external radiofrequency magnetic fields. Each shape-memory-alloy actuator is driven by a wireless resonant heater which generates heat only when the field frequency is tuned to the resonant frequency of the heater. Multiple actuators coupled with the heater circuits that are designed to have different resonant frequencies in the range of 135–295 MHz are selectively and simultaneously controlled by modulating the field frequency to the resonant frequencies of the corresponding heaters. A wireless microsyringe device that has three actuator–heater components and a flexible parylene reservoir is developed. The 5 µl reservoir is squeezed by the 5 mm long cantilever-type actuators to eject controlled amount of liquid from the reservoir. Using the device with an acidic solution loaded in the reservoir, sequential modifications of the pH level in the liquid are experimentally demonstrated through the selective control of the three actuators. The thermal characterization of the actuator using infrared imaging shows a temperature increase of 50 °C in 4 s and the full activation of the actuator in 8 s with 300 mW field output power.

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A release-on-demand wireless CMOS drug delivery SoC based on electrothermal activation technique

Cited by 19 publications

References 7 publications

Advances and Challenges in IoT-Based Smart Drug Delivery Systems: A Comprehensive Review

Advances and Challenges in IoT-Based Smart Drug Delivery Systems: A Comprehensive Review

Analysis and Design of Colpitts Oscillator for Short-range WSN

Wireless microfluidic control with integrated shape-memory-alloy actuators operated by field frequency modulation

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