A relationship between plasma uric acid concentration and the apparent response to frusemide in normal subjects.

Plasma uric acid and spironolactone response in healthy subjects.

“…In separate studies there was no significant relationship between PUA and the plasma or urinary levels of canrenone, the principal unconjugated metabolite of spironolactone, and there was therefore no evidence that the pharmacological relationship reflects a link between PUA and spironolactone metabolism. It has been shown that PUA concentration also relates to the urinary electrolyte excretion following single doses of frusemide (Ramsay, Tidd, Auty, Levine & Branch, 1975;Branch, Levine, Read, Vander Elst, Rupp, Shelton & Ramsay, 1976). The evidence available at present would favour a relationship not specifically between PUA and spironolactone response, but some more general relationship between PUA and the response to diuretic agents, the nature of which remains to be elucidated.…”

Plasma Uric Acid Concentration Related to the Urinary Excretion of Aldosterone and of Electrolytes in Normal Subjects

“…Variation in the response of normal subjects to single doses of frusemide can be related in part to differences in plasma uric acid concentration before treatment (Ramsay, Tidd, Auty, Levine & Branch, 1975b). Subjects with a higher plasma uric acid excreted more potassium and had a lower urinary Na/K ratio during the diuretic response.…”