A regional spatial environmental multimedia modeling (RSEMM) approach for assessing the risk of antibiotics in river basin system – a China case study

Dong, Jinxin; Chen, Zhi; Wang, Hongtao; Guo, Jianbo; Pu, Yong; Han, Yuechen; Xia, Jun; Haghighat, Fariborz

doi:10.1016/j.scs.2019.101624

Cited by 10 publications

(3 citation statements)

References 37 publications

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“…Even though the fugacity models have been shown to successfully predict environmental concentrations of antibiotics and have been linked to performed risk assessment of antibiotics, they have not been widely applied to assess the risk of antibiotic resistance ( Zhang et al, 2015 ; Chen et al, 2018 ; Dong et al, 2019 ). In this study, the risk of antibiotic resistance genes selection was estimated by incorporating the fugacity model into the risk assessment framework, enabling the guidance of governments to develop the risk-based management measures to reduce the amount of antibiotic entering the environment ( European Medicines Agency, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, concentrations of antibiotics in air, water, soil, and sediment compartments in river basins have been successfully estimated by applying the fugacity model, one of the most successful types of multimedia environmental models, informing estimates for ecological and human health risk assessment and linking to bacterial resistance ( Zhang et al, 2015 ; Chen et al, 2018 ; Dong et al, 2019 ). The fugacity approach was first established in Mackay (1979) .…”

Section: Introductionmentioning

confidence: 99%

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A Risk-Based Approach for Managing Aquaculture Used Oxytetracycline-Induced TetR in Surface Water Across Taiwan Regions

Chen

Wang

et al. 2021

Front. Pharmacol.

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Oxytetracycline (OTC), one of the most important antibiotics in aquaculture industry, has been linked to emergence of antibiotic resistant genes in the aquatic environment. Given rapid growth of the aquaculture industry and unregulated use of antibiotics, it is necessary to implement measures to mitigate the impact of antibiotic resistance risk on environmental and human health. However, there is a lack of quantitative models to properly assess risk of antibiotic resistance associated with environmentally relevant antibiotic residues. To address this issue, here we developed a computational framework to assess antibiotic resistance risk posed by low-concentration OTC in aquaculture ponds and rivers across Taiwan regions. To this end, estimated amount of aquaculture used OTC as a crucial input parameter was incorporated into a multimedia fugacity model to predict environmental concentrations of OTC in surface water/sediment. A pharmacodynamic-based dose–response model was used to characterize the OTC concentration–antibiotic resistance relationships. The risk of antibiotic resistance selection in an aquatic environment could be assessed based on a probabilistic risk model. We also established a control measure model to manage the risks of substantial OTC-induced antibiotic resistance impacts. We found that OTC residues were likely to pose a high risk of tetracycline resistance (tetR) genes selection in aquaculture ponds among all the study basins, whereas risk of tetR genes selection in rivers experienced a variably changing fashion. We also showed that it was extremely difficult to moderate the tetR genes selection rates to less than 10% increase in aquaculture ponds situated at northeastern river basins in that the minimum reductions on OTC emission rates during spring, summer, and autumn were greater than 90%. On the other hand, water concentrations of OTC during spring and summer in southwestern rivers should be prioritized to be severely limited by reducing 67 and 25% of OTC emission rate, respectively. Overall, incorporating a computational fugacity model into a risk assessment framework can identify relative higher risk regions to provide the risk-based control strategies for public health decision-making and development of robust quantitative methods to zero-in on environment with high risk of tetR genes selection in relation to aquaculture-used pharmaceutical residues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Risk-Based Approach for Managing Aquaculture Used Oxytetracycline-Induced TetR in Surface Water Across Taiwan Regions

Chen

Wang

et al. 2021

Front. Pharmacol.

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“…Recent studies have reported widely different emissions from food animals in China. One estimated that 45,360 tonnes of 36 widely used antibiotics were emitted by food animals into the Chinese environment in 2013; in contrast, a much lower release from food animals was recently reportedonly 4,131 tonnes in China in 2014. , Existing studies on antibiotic emission, as well as environmental transport and distribution in China have limitations, such as on spatial resolution and substance coverage or on considerations of antibiotic removal during livestock excretion treatment, intermedia chemical transport processes, and ionizable features of antibiotics in the modeling approach. − Global studies including China have mainly investigated the use of veterinary antibiotics but rarely assessed environmental release and contamination. ,, Furthermore, previous estimates normally assumed identical application of antibiotics to individual animals within the same livestock species in a country. However, notable geographical disparities were found in residues of some veterinary antibiotics in manures, implying potential differences in regional antibiotic application .…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Assessment of Environmental Emissions, Fate, and Risks of Veterinary Antibiotics in China: An Environmental Fate Modeling Approach

Li,

Zhu,

Zhong

et al. 2024

Environ. Sci. Technol.

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China is one of the major global consumers of veterinary antibiotics. Insufficient recognition of emissions and environmental contamination hamper global efforts to prevent antibiotic resistance development. This pioneering study combined empirical data and modeling approaches to predict total 2010−2020 emissions of 80 veterinary antibiotics ranging from 23,110 to 40,850 tonnes/year, after 36−50% antibiotic removal by manure treatment. Following an initial increase of 10% from 2010 to 2015, emissions declined thereafter by 43%. While 85% of emissions discharged into soils, approximately 56%, 23%, and 18% of environmental residue were ultimately distributed in soils, freshwaters, and seawaters under steady-state conditions. In 2020, 657 (319−1470) tonnes entered the ocean from inland freshwaters. Median ∑antibiotics concentrations were estimated at 4.7 × 10 3 ng/L in freshwaters and 2.9 ng/g in soils, with tetracyclines and sulfonamides as the predominant components. We identified 44 veterinary antibiotics potentially posing high risks of resistance development in freshwaters, with seven exhibiting high risks in >10% of Chinese freshwater areas. Tetracyclines were the category with the most antibiotics exhibiting elevated risks; however, sulfamethylthiazole demonstrated the highest individual compound risk. The Haihe River Basin displayed the highest susceptibility overall. The findings offer valuable support for control of veterinary antibiotic contamination in China.

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Experimental and numerical elucidation of the fate and transport of antibiotics in aquatic environment: A review

Kashyap,

Nishil,

Thatikonda

2023

Environ Monit Assess

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A regional spatial environmental multimedia modeling (RSEMM) approach for assessing the risk of antibiotics in river basin system – a China case study

Cited by 10 publications

References 37 publications

A Risk-Based Approach for Managing Aquaculture Used Oxytetracycline-Induced TetR in Surface Water Across Taiwan Regions

A Risk-Based Approach for Managing Aquaculture Used Oxytetracycline-Induced TetR in Surface Water Across Taiwan Regions

Comprehensive Assessment of Environmental Emissions, Fate, and Risks of Veterinary Antibiotics in China: An Environmental Fate Modeling Approach

Experimental and numerical elucidation of the fate and transport of antibiotics in aquatic environment: A review

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