A redox-responsive hyaluronic acid-based hydrogel for chronic wound management

Gao, Ziyu; Golland, Ben; Tronci, Giuseppe; Thornton, Paul D.

doi:10.1039/c9tb01683j

Cited by 46 publications

(35 citation statements)

References 40 publications

(37 reference statements)

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“…In contrast, modern hydrogels such as Tyrosur® can support all phases of wound healing. In the cleansing phase hydrogel bases support the removal of exudate, cell debris, foreign bodies and germs (autolytic debridement) [25]. In the granulation phase, hydrogels optimally moisturize the wound and thus provide an intensively hydrated matrix, which can promote cell migration into the wound [26].…”

Section: Discussionmentioning

confidence: 99%

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Rüther¹,

Voss²

2021

Heliyon

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Purpose Five different galenics were analyzed and compared concerning tissue breathability and gas exchange with the environment after an application period of 6 h on pig ear skin. Aim was to find the most suitable galenics for efficient moist treatment for everyday injuries (abrasions, lacerations and cuts) without influencing the transepidermal water loss. Methods A quantity of 0.1 g of the different test preparations was applied once topically to an area of 2 cm 2 . The analysis of the breathability was performed by TEWL (transepidermal water loss) measurements in the first hour after product application. The moisture retention effect was assessed by corneometry in the first 5 h after product application. Results The hydrogel preparations showed a higher breathability in contrast to a semi-occlusive ointment and petrolatum. The same applies to the moisture penetration of the skin. Here, all hydrogel formulations showed the highest tissue hydration. After 3 h an additional increase in moisture was observed for the areas treated with Tyrosur® CareExpert Wound Gel and the ointment. Conclusion In contrast to petrolatum and the semi-occlusive ointment, treatment with the hydrogels led to a preservation of the breathability and good moistening of the tissue, which is due to the galenics of the gels consisting of water, carbomer and propylene glycol. The increase in moisture after 3 h in areas treated with Tyrosur® CareExpert Wound Gel and the semi-occlusive ointment indicates a sustained moisturizing effect mediated by dexpanthenol.

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Section: Discussionmentioning

confidence: 99%

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Rüther¹,

Voss²

2021

Heliyon

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“…This characteristic may be exploited to generate bespoke Fe 3+ -GSH carriers capable of the prolonged, or redox-mediated, release of GSH to, for example, chronic tissues that have downregulated levels of GSH. 28 The paramagnetic property of Fe 3+ -GSH was observed using a vibrating-sample magnetometer and increased in magnetic moment from −0.1474 emu g −1 to 0.1474 emu g −1 under 3 T magnetic field, revealing the paramagnetism of the complex (Fig. S12 †).…”

Section: Papermentioning

confidence: 99%

The facile and additive-free synthesis of a cell-friendly iron(iii)–glutathione complex

et al. 2020

Self Cite

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“…hPLSCs used for chondrogenic differentiation and cartilage tissue engineering [137] Wound monitoring and repair Redox-responsive, HA-based hydrogel acted as a point-of-care wound monitor, sensitive to variations in glutathione (GSH) concentration. Allowed fibroblast proliferation for 7 days to promote wound repair [91] Wound monitoring and repair Thermoresponsive hydrogel containing EGF-loaded layer-by-layer assembled microcapsules, bFGF, lysozyme, and HA was used for sequential expression of growth factors in a sterile-moist microenvironment to promote scar-free tissue healing in the oral mucosa for chronic trauma repair and cosmetic surgery [138] Nanodoctor for inflammatory disease…”

Section: Microarraymentioning

confidence: 99%

Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

Niazi

Alizadeh

Zarebkohan

et al. 2021

Adv Funct Materials

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Advanced forms of hydrogels have many inherently desirable properties and can be designed with different structures and functions. In particular, bioresponsive multifunctional hydrogels can carry out sophisticated biological functions. These include in situ single-cell approaches, capturing, analysis, and release of living cells, biomimetics of cell, tissue, and tumor-specific niches. They can allow in vivo cell manipulation and act as novel drug delivery systems, allowing diagnostic, therapeutic, vaccination, and immunotherapy methods. In the present review of multitasking hydrogels, new approaches and devices classified into point-of-care testing (POCT), microarrays, single-cell/rare cell approaches, artificial membranes, biomimetic modeling systems, nanodoctors, and microneedle patches are summarized. The potentials and application of each format are critically discussed, and some limitations are highlighted. Finally, how hydrogels can enable an "all-in-one platform" to play a key role in cancer therapy, regenerative medicine, and the treatment of inflammatory, degenerative, genetic, and metabolic diseases is being looked forward to.

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A redox-responsive hyaluronic acid-based hydrogel for chronic wound management

Abstract: A low-cost hyaluronic acid hydrogel that is sensitive to the presence of glutathione, non-cytotoxic, and consequently highly-promising for chronic wound diagnosis and repair.

Cited by 46 publications

References 40 publications

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

The facile and additive-free synthesis of a cell-friendly iron(iii)–glutathione complex

Advanced Bioresponsive Multitasking Hydrogels in the New Era of Biomedicine

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