A redox-activated theranostic nanoplatform: toward glutathione-response imaging guided enhanced-photodynamic therapy

Abstract

A redox-sensitive nanoagent (DCMn-RA) for dual-mode GSH detection, NIR-II imaging and enhanced PDT is described.

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

“…MnO 2 is a common material to enhance PDT treatment and imaging. Mn 2+ could react with H 2 O 2 in the tumor, then downregulate the expression of HIF-1 to increase oxygen content and optimize MRI imaging [ 138 , 139 ]. A nanoplatform based on mesoporous polydopamine (MPDA) modified with Pt also produces O 2 by decomposing overexpressed H 2 O 2 in the tumor.…”

A RuII Polypyridyl Alkyne Complex Based Metal–Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy

“…[14] The weak changes in the UV/Vis spectra over time indicatedt hat Ra was stable in aqueous and phosphate buffered saline (PBS, pH 7.4) solution (FigureS1i nt he Supporting Information).T hen, to realize our multifunctional nanoplatform, UiO-66-N 3 with an arrow size distribution ( Figure S2 in the Supporting Information) was synthesized. [14] The weak changes in the UV/Vis spectra over time indicatedt hat Ra was stable in aqueous and phosphate buffered saline (PBS, pH 7.4) solution (FigureS1i nt he Supporting Information).T hen, to realize our multifunctional nanoplatform, UiO-66-N 3 with an arrow size distribution ( Figure S2 in the Supporting Information) was synthesized.…”

“…Initially,aphotosensitizer,b ased on ar uthenium(II) complex with an alkynyl group in its main ligand (Ra;S cheme 1a), was synthesized and characterizeda sd escribed in our previous work. [14] The weak changes in the UV/Vis spectra over time indicatedt hat Ra was stable in aqueous and phosphate buffered saline (PBS, pH 7.4) solution (FigureS1i nt he Supporting Information).T hen, to realize our multifunctional nanoplatform, UiO-66-N 3 with an arrow size distribution ( Figure S2 in the Supporting Information) was synthesized. Scanning electron microscopy (SEM)a nd transmission electron microscopy (TEM) images (Figure1A) of the light-yellowp roduct revealed that the nanoparticles have an average diameter of about1 10 nm.…”

“…Ra was synthesized and characterized as in our previous work. [14] 1 HNMR (400 MHz, DMSO): d = 9.09 (d, J = 7.5 Hz, 2H), 8.90 (d, J = 8.4 Hz, 2H), 8.86 (d, J = 8.2 Hz, 2H), 8.50 (d, J = 8.6 Hz, 2H), 8.23 (ddd, J = 8.0, 4.4, 1.4 Hz, 4H), 8.12 (td, J = 8.0, 1.4 Hz, 2H), 8.03 (d, J = 4.7 Hz, 2H), 7.91 (dd, J = 8.2, 5.3 Hz, 2H), 7.86 (d, J = 4.9 Hz, 2H), 7.60 (ddd, J = 7.2, 5.8, 3.1 Hz, 4H), 7.39-7.34 (m, 2H), 5.03 (d, J = 2.4 Hz, 2H), 3.69 ppm (t, J = 2.4 Hz, 1H); 13…”

Intratumoral Glutathione Activatable Nanoprobes for Fluorescence and 19F Magnetic Resonance Turn-On Imaging

“…Among various biological stimulus imaging probes such as pH, , enzyme, , redox, and so on, redox-activated imaging probes are extremely intriguing because of the important role of redox processes in organisms. − The reduced glutathione, a peptide composed of glutamic acid, cysteine, and glycine, is an essential endogenous antioxidant that plays a vital part in physiological functions such as defense against toxins and free radicals. , In addition, the concentration of GSH is implicated in many diseases typically associated with cancer, dementia, or neurodegenerative diseases . To date, GSH-responsive 19 F MRI probes were mainly constructed by introducing redox sensitive moieties such as disulfide linkers and 4-dinitrobenzenesulfonyl groups in fluorinated polymers.…”