A recurrence of advanced malignant sex cord tumor with annular tubules: case report

Abstract

Sex cord tumor with annular tubules (SCTAT) is a rare special type of ovarian sex cordstromal tumor, which has not achieved a standard treatment regimen currently. The aim of this report was to provide possible reference for treatment and supervision of recurrent advanced malignant SCTAT. A 33-year-old unmarried female with malignant SCTAT emerged recurrence after the cytoreductive surgery but preserved fertility and postoperative chemotherapy (3 cycles PEB regimens) 12 months. She was performed preoperative adjuvant chemotherapy (3 cycles, paclitaxel liposome and nedaplatin) before the third operation of secondary cytoreductive surgery, followed by platinum-based chemotherapy (7 cycles, TC regimens) timely because of dissatisfactory efficacy under the evaluation in combination with prior comprehensive treatment and PET/CT. The surgical stage was IIIB. She acquired complete remission after therapy and needed to regularly follow up every 3-6 months for 2 years and every 6-12 months after 2 years. There was no evidence of malignant SCTAT recurrence at the follow-up 24 months past the third surgery. No abnormality was found in other examination indexes, and menstruation was regular. The regular supervision of the patient was continually performed. The diagnosis of recurrent advanced malignant SCTAT was established on history and final pathology examination, whose prognosis mainly depended on the appropriate strategy of surgery and chemotherapy regimens. The classical TC regimens could be considered if the efficacy of other chemotherapy regimens were unsatisfactory. Regular follow-up was essential.

Exceptional lymph node recurrence of an unusual ovarian tumor 16 years later: a case report

“…However, they have a high potential for late recurrence, which can be up to 30 years after diagnosis and treatment [ 4 ]. This case has been reported in line with the SCARE guidelines [ 8 ].…”

“…In our case, the main symptom was amenorrhea at the initial diagnosis and at the two recurrences, and we opted for the conservative surgery because of the young age of our patient. The rate of metastases in patients with sporadic SCTAT is around 20%, and they occur mainly in women of childbearing age [ 8 ]. However, the rate of recurrence ranges from 1% to 2.3% in the series [ 3 ].…”

“…Laparoscopy is recommended for first surgery, and for the relapse. It can be also useful after neoadjuvant chemotherapy to evaluate the response of chemotherapy, although this response can be evaluated by PET scan and magnetic resonance imaging (MRI) [ 8 ]. Due to the rarity of these tumors, there are currently no standards for treatment.…”

Bilateral Peutz–Jeghers-Associated Sex Cord Tumor With Annular Tubules Combined With Unilateral Adult Granulosa Cell Tumor: A Case Report

“…9 The first choice for simple SCTAT is surgical resection. [10][11][12][13] In this case, due to the diagnosis of SCTAT combined with AGCT, uterine and bilateral appendages were resected and lymph node dissection was performed. In previous literature, patients with SCTAT combined with AGCT were also treated with uterine and bilateral appendage resection and lymph node dissection.…”

Sex cord tumor with annular tubules of ovary- An unusual case report

“…Supraclavicular lymph nodes and other organs like liver, lung, kidneys, peritoneum & omentum may be involved in advanced cases. 8 The duration ranges from 3 months to 20 years for first time recurrence of SCTAT as reported by Kulkarni. 9 Serum estradiol and progesterone levels can be done to monitor progression or regression of the tumor.…”