A re-examination of the organ specificity of lens antigens

Clayton, R. M.; Campbell, John C.; Truman, D. E. S.

doi:10.1016/s0014-4835(68)80022-3

Cited by 82 publications

(16 citation statements)

References 39 publications

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“…The finding of pratically identical results with both antilens and antiuveoretinal anti bodies was expected; the cross-reactivity be tween lens and uveoretinal tissues is well established [Clayton et al, 1968] and our antiuveoretinal antibodies showed cross-re- activity and identity lines with both extracts (fig. 6).…”

Section: Discussionsupporting

confidence: 82%

Immunopathology of the Lens

D'ermo¹,

Ag²,

Mancini³

et al. 1978

Ophthalmologica

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Section: Discussionsupporting

confidence: 82%

Immunopathology of the Lens

D'ermo¹,

Ag²,

Mancini³

et al. 1978

Ophthalmologica

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“…3). 3-Crystallin has been detected by immunological criteria in the chicken cornea (24,25). We show here by peptide sequencing the presence of the 81 polypeptide in the embryonic chicken cornea (Fig.…”

Section: Resultsmentioning

confidence: 53%

Taxon-specific recruitment of enzymes as major soluble proteins in the corneal epithelium of three mammals, chicken, and squid.

Cuthbertson

Tomarev

Piatigorsky

1992

Proc. Natl. Acad. Sci. U.S.A.

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Studies of others have shown that class 3 aldehyde dehydrogenase is a major component of the epithelial cells of the mammalian cornea. Here we demonstrate by peptide sequencing that other major proteins of the corneal epithelium are also identical or related to enzymes in the human, mouse, kangaroo, chicken, and squid. Aldehyde dehydrogenase class 3 was found to be the major protein of human, mouse, and kangaroo corneal epithelial cells. Peptidyl prolyl cis-trans isomerase (cyclophilin) or a homologue thereof is strikingly abundant in the corneal epithelial cells of chicken, but not mammals, and appears to be absent from the cornea of squid. By contrast, enolase or its homologue is relatively abundant in both the mammalian and chicken corneal epithelial cells. In some instances, abundant enzymes are common to cornea and lens in the same species-for example, arininosuccinate lyase/81-crystallin in the chicken and glutathione S-transferase-like protein in the squid; in other cases, the abundant proteins in the cornea have not been found as lens crystallins in any species-for example, aldehyde dehydrogenase class 3 and cyclophilin. These data suggest that enzymes and certain enzyme-crystallins have been recruited as major corneal proteins in a taxon-specific manner and may serve structural rather than, or as well as, enzymatic roles in corneal epithelial cells.

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“…However, this idea became doubtful when these proteins were found occasionally outside the lens [3, 4, 5]. The real extralenticular detection of αB-crystallin, the basic subunit of α-crystallin, came when this protein was discovered in muscle, heart, brain and kidney [6].…”

Section: Introductionmentioning

confidence: 99%

Alpha-B-Crystallin in Neuropathology

Rijk

Bloemendal

2000

Ophthalmologica

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αB-Crystallin, which has homology with the small heat shock proteins, is the basic subunit of α-crystallin, a major component of the vertebrate eye lens. These crystallins have for a long time been thought to be absolutely lens specific. However, about a decade ago αB-crystallin has been detected extralenticularly in many tissues among which the central nervous system. Under pathological conditions the expression level of αB-crystallin frequently increases. For this reason it is considered to be a useful marker in a variety of neurodegenerative diseases. In this mini-review, a number of typical neurodegenerative disorders is dealt with in which αB-crystallin may play a role.

show abstract

A re-examination of the organ specificity of lens antigens

Cited by 82 publications

References 39 publications

Immunopathology of the Lens

Immunopathology of the Lens

Taxon-specific recruitment of enzymes as major soluble proteins in the corneal epithelium of three mammals, chicken, and squid.

Alpha-B-Crystallin in Neuropathology

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