A re-evaluation of effects of acute central congestion on pulmonary compliance in normal subjects

Bondurant, Stuart; Mead, J.; Cook, Charles D.

doi:10.1152/jappl.1960.15.5.875

Cited by 23 publications

(12 citation statements)

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“…Acute distention up to a hydrostatic column, 25 cm of blood, did not cause either further increase or a decrease in compliance. This is in accord with Bondurant's findings that acute pulmonary congestion in normal humans, induced by inflation of an antigravity suit, did not change pulmonary compliance (12).…”

Section: Resultssupporting

confidence: 91%

Effect of Pulmonary Blood Flow upon Lung Mechanics*

Giannelli¹,

Ayres²,

Buehler³

1967

J. Clin. Invest.

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Abstract. Airway pressure was continuously recorded in an isolated horizontally mounted canine heart-lung preparation during abrupt, stepwise 100-200 ml inflations to 20-25 cm water pressure, and subsequent deflations. With each change in volume there was a steep rise or fall in pressure, followed by stress relaxation to a static equilibrium airway pressure. Comparison was made between the nonperfused state and during perfusion with whole blood at 100 ml/kg dog wt per min, and left atrial pressure of 10 mm Hg. Pressure tracings were similar during deflation in the perfused and the nonperfused lung. During inflation, in the middle range of lung inflation volumes, the peak inflation and equilibrium airway pressures were greater in the nonperfused state; maximum difference of static pressures in nine preparations averaged 146% of perfused values and the average stress relaxation difference from eight of these was 276%. Lung distensibility was the same with packed red cells or plasma perfusates and was not changed by varying the perfusion rate up to 220 ml/kg per min. During cyclic ventilation, dynamic compliance was similarly greater in the perfused than in the nonperfused state in the middle range of inflation volumes. Static distention of the vascular bed produced similar results with progressive improvement in distensibility in midinflation range up to a hydrostatic pressure of 15 cm blood. These data suggest that the distended pulmonary vascular bed provides structural airway support which facilitates entry of gas diminished pressure. IntroductionThe influence of the pulmonary vascular bed upon pulmonary mechanics is not clear. Basch, in 1887, suggested that perfusion of the pulmonary capillaries under normal conditions serves to maintain alveolar distention (1). Other investigators

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Section: Resultssupporting

confidence: 91%

Effect of Pulmonary Blood Flow upon Lung Mechanics*

Giannelli¹,

Ayres²,

Buehler³

1967

J. Clin. Invest.

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“…The dependence in man of dynamic CL upon pulmonary vascular pressure, or volume, or both, was shown by Bondurant and co-workers (7,39,40), who produced acute central vascular engorgement by G-suit inflation and decreased CL by this maneuver. The effects of atropine on CL suggest that, just as increased pulmonary vascular pressures decrease CL, decreased pulmonary vascular pressures and volume increase CL.…”

Section: Discussionmentioning

confidence: 83%

The Effect of Changes in the Pulmonary Vascular Bed Produced by Atropine, Pulmonary Engorgement, and Positive-Pressure Breathing on Diffusing and Mechanical Properties of the Lung*

Daly¹,

Ross²,

Behnke³

1963

J. Clin. Invest.

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Several factors probably have some role in determining the volume of the effectively ventilated pulmonary capillary bed, including pulmonary blood flow, pulmonary vascular pressures, pulmonary blood volume, alveolar and blood gas tensions, and mechanical effects of ventilation.Others have found that atropine sulfate, 2.0 mg iv, increases cardiac output (1, 2), decreases central venous pressure (1, 2), and affects the distribution of the blood volume as shown by plethysmographic study of extremity venous volume (3). This drug, then, provides an unusual rearrangement of some of the determinants of pulmonary capillary function and, for the present study, was used either alone or in combination with positivepressure breathing or pulmonary vascular engorgement produced by G-suit inflation.This study was carried out to provide further information concerning the interaction of cardiac output, pulmonary vascular pressure, and pulmonary blood volume as determinants of the volume of effectively ventilated capillaries by de-termining the effects of changes in the pulmonary vascular bed produced by atropine, pulmonary engorgement, and positive-pressure breathing on the diffusing and mechanical properties of the lung.

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“…Thus Bondurant, Hickam & Isley (1957) noted a fall in lung compliance with acute pulmonary congestion, whereas, later (Bondurant, Mead & Cook, 1960) it was suggested that this may have been due to an artifact. If an increase in pulmonary blood volume in man decreases lung compliance, an opposite change might be expected with decrease in pulmonary blood volume.…”

Section: Discussionmentioning

confidence: 99%

Effects of Immersion in Water and Changes in Intrathoracic Blood Volume on Lung Function in Man

Burki

1976

Clinical Science

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1. In healthy, normal subjects simultaneous peripheral venous occlusion of all four limbs caused a small but significant increase in vital capacity (VC) and single-breath carbon monoxide transfer factor (DLCO) without significantly changing total lung capacity (TLC), residual volume (RV), pulmonary gas flow or pulmonary compliance. 2. Immersion in water to the neck resulted in a small but significant fall in VC, FEV 1.0/FVC and TLC, and a rise in DLCO, but flow/volume curves and 'closing volume' were unchanged. Peripheral venous occlusion during immersion only significantly increased VC and DLCO; pulmonary compliance and flow/volume curves did not alter significantly. 3. It is concluded that peripheral venous occlusion produces these effects by altering intrathoracic blood volume. Water immersion reduces TLC, mainly from the hydrostatic pressure, and VC is reduced from both the hydrostatic pressure and the increase in intrathoracic blood volume consequent on immersion. The increase in DLCO is due, almost entirely, to the increase in intrathoracic blood volume.

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A re-evaluation of effects of acute central congestion on pulmonary compliance in normal subjects

Cited by 23 publications

References 0 publications

Effect of Pulmonary Blood Flow upon Lung Mechanics*

Effect of Pulmonary Blood Flow upon Lung Mechanics*

The Effect of Changes in the Pulmonary Vascular Bed Produced by Atropine, Pulmonary Engorgement, and Positive-Pressure Breathing on Diffusing and Mechanical Properties of the Lung*

Effects of Immersion in Water and Changes in Intrathoracic Blood Volume on Lung Function in Man

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