A re-appraisal of the development of the anterior chamber

Sevel, David; Bothwell, Linda; Hiss, Paul; Isaacs, R; Miller, D. Josh

doi:10.3109/13816818509004112

Cited by 2 publications

(7 citation statements)

References 7 publications

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“…The decrease in cellularity is attributable to rapid corneal growth and not cell death (Murphy et al, 1984). In agreement with Sevel and Isaacs (1988), the corneal endothelium matures before the corneal epithelium, forming a single cell layer that remains stable throughout embryological development while corneal epithelium, stratification, and maturation occur postnatally.…”

Section: Discussionsupporting

confidence: 87%

“…In this study, the DM developed later than Bowman's membrane (BM), which formed on the 23rd day of gestation. In contrast, Sevel and Isaacs (1988) assert that the DM comes before the BM. Additionally, we discovered that the appearance of DM coincided with the disappearance of BM.…”

Section: Discussionmentioning

confidence: 97%

“…The present study revealed that Bowman's membrane appears prenatally on the 23rd day of gestation, which is consistent with previous rabbit studies (Abdo et al, 2017; Hayashi et al, 2002). The Bowman's membrane is a longitudinal condensation formed by the processes of mesenchymal cells in the corneal stroma (Sevel & Isaacs, 1988). On the thirtieth gestational day, we discovered that it had disappeared.…”

Section: Discussionmentioning

confidence: 99%

“…On the twelfth day of gestation, mesenchymal tissue invades the space between the lens vesicle and the surface ectoderm, initiating the development of the corneal stroma. The detached lens vesicle has a compressive effect on the growth and proliferation of the precursors of the corneal stroma, the mesenchymal cells (Sevel & Isaacs, 1988). On the sixteenth day, the secondary stroma begins to develop with the appearance of keratocytes at the eyeball's periphery.…”

Section: Discussionmentioning

confidence: 99%

“…It appears as a continuous layer of a fibril‐based matrix beneath the endothelial cells. It develops from the processes of the deep mesenchymal cells of the stroma, according to Sevel and Isaacs (1988). However, according to Graw (2003), DM is produced by the corneal endothelium.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Morphogenetic events influencing corneal maturation, development, and transparency: Light and electron microscopic study

Ibrahim

Hifny

Elhanbaly

et al. 2023

Microscopy Res & Technique

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The development of the cornea is a fascinating process. Its dual origin involves the differentiation of surface ectoderm cells and the migration of mesenchymal cells of neural crest origin. This research aimed to demonstrate the morphogenesis of the rabbit cornea from fetal to postnatal life using light‐ and electron microscopy, and immunohistochemical analysis. There were 27 rabbit embryos and nine rabbits used. The rabbit cornea begins its prenatal development on the twelfth day of gestation. The surface ectoderm differentiates into the corneal epithelium on day 13. Intriguingly, telocytes were visible within the epithelium. The secondary stroma develops on the sixteenth day of gestation by differentiation of keratocytes. At the age of 2 weeks, the lamellae of collagenous fibers become highly organized, and the stroma becomes avascular, indicating that the cornea has become transparent. Bowman's membrane appears on day 23 of pregnancy and disappears on day 30. The Descemet's membrane appears at this time and continues to thicken postnatally. The corneal endothelium appears on the twentieth gestational day as double layer of flattened cells and becomes a single layer of cuboidal cells on day 30. The spaces between the endothelial cells resemble craters. VEGF immunohistochemical expression increases over the course of development, reaching its peak in the first week after birth before decreasing in all corneal layers and becoming negative in the stroma. In conclusion, numerous morphogenetic events contribute to corneal maturation and transparency, allowing the cornea to perform its vital functions.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Morphogenetic events influencing corneal maturation, development, and transparency: Light and electron microscopic study

Ibrahim

Hifny

Elhanbaly

et al. 2023

Microscopy Res & Technique

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Neonatal and Juvenile Ocular Development in Göttingen Minipigs and Domestic Pigs: A Histomorphological and Immunohistochemical Study

Vrolyk

Desmarais²,

Lambert³

et al. 2020

Vet Pathol

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Pigs are considered one of the relevant animal models for ocular research as they share several histological and anatomical similarities with the human eye. With the increasing interest in juvenile animal models, this study aimed to describe the postnatal development of ocular structures in 16 Göttingen minipigs and 25 F2 domestic pigs, between birth and 6 months of age, using histopathology and immunohistochemistry against Ki-67, caspase-3, calbindin, glial fibrillary acidic protein, rhodopsin, and synaptophysin. All ocular structures in both pig breeds were incompletely developed at birth and for variable periods postnatally. Noteworthy histological features of immaturity included vascularization in the corneal stroma in neonatal Göttingen minipigs, increased cellularity in different substructures, remnants of the hyaloid vasculature, short and poorly ramified ciliary body processes, and a poorly developed cone inner segment. Increased cellular proliferation, highlighted by abundant Ki-67 immunolabeling, was observed in almost all developing structures of the pig eye for variable periods postnatally. Apoptosis, highlighted with caspase-3 immunolabeling, was observed in the retinal inner nuclear layer at birth and in the regressing hyaloid vasculature remnants. Immunohistochemistry against rhodopsin, synaptophysin, and calbindin demonstrated the short size of the developing photoreceptors and the immature cone inner segment morphology. Calbindin labeling revealed significant differences in the amount of positively labeled cone nuclei between the retinal area centralis and the non–area centralis regions. The elongation of Müller cell processes in the developing retina was shown with glial fibrillary acidic protein. In both pig breeds, the eyes reached histomorphological and immunohistochemical maturity at 6 months of age.

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A re-appraisal of the development of the anterior chamber

Cited by 2 publications

References 7 publications

Morphogenetic events influencing corneal maturation, development, and transparency: Light and electron microscopic study

Morphogenetic events influencing corneal maturation, development, and transparency: Light and electron microscopic study

Neonatal and Juvenile Ocular Development in Göttingen Minipigs and Domestic Pigs: A Histomorphological and Immunohistochemical Study

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