A rational approach to cervical neuroblastoma

Cushing, Barbara; Slovis, Thomas L.; Philippart, Arvin I.; Das, Lakshmi; Watts, Frederick B.; Corbett, David P.; Reed, Joseph O.; Hertzler, Jack H.; Belenky, Walter M.

doi:10.1002/1097-0142(19820815)50:4<785::aid-cncr2820500427>3.0.co;2-p

Cited by 19 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The tumor may invade the cranial nerves IX-XII, and extend to the base of the skull through the jugular and lacerum foramina [13]. Invasion through the intervertebral foramina is exceptional and usually occurs for NB in the cervicothoracic localization [14].…”

Section: Discussionmentioning

confidence: 99%

“…Cervical NB is most common in the first 3 years of life [14]. The median age in this series was 18.5 months.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically cervical NB presents as a palpable indolent mass in the lateral neck or may be result in symptomatic compression of cervical structures [14], i.e. cranial nerves, sympathetic chain and/or upper airway or digestive tract.…”

Section: Discussionmentioning

confidence: 99%

“…Investigation by ultrasonography is useful to locate the tumor [4] and differentiate from benign masses such as thyroid enlargement, fibromatosis colli, cystic hygroma, branchial cleft or digestive cysts [4,14,20]. A retropharyngeal firm smooth mass posterior to the vascular sheet is consistent with the diagnosis of NB [15].…”

Section: Discussionmentioning

confidence: 99%

“…Pharyngeal dysfunction, vocal cord paralysis, and swallowing disturbances are common but self-limited sequels. Cushing et al [14] reported post-operative deglutition disturbances in two patients treated using parenteral hyperalimentation followed by enteral feeding via gastrostomy or nasogastric tube. Both patients recovered, after 2 months and 1 year.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Localized cervical neuroblastoma: prevention of surgical complications

Haddad¹,

Triglia²,

Helardot³

et al. 2003

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Cervical NB is most common in the first 3 years of life [14]. The median age in this series was 18.5 months.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Localized cervical neuroblastoma: prevention of surgical complications

Haddad¹,

Triglia²,

Helardot³

et al. 2003

International Journal of Pediatric Otorhinolaryngology

View full text Add to dashboard Cite

Primary Retropharyngeal Neuroblastoma

Godey¹,

Pagot²,

Morandi³

et al. 2000

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Neuroblastoma is the most frequent extracerebral tumor in infants younger than 1 year. It is most often localized in the abdomen or thorax. A cervical localization is rare, and in the majority of cases, the tumor is located in the lateral region of the neck, lateral to the carotid artery. 1 We describe a newborn boy who presented with difficulty in breathing associated with a retropharyngeal neuroblastoma. A retropharyngeal localization is exceptional, and, to our knowledge, there have been no previous reports in which retropharyngeal neuroblastomas were differentiated from lateral cervical neuroblastomas. Our goal is to emphasize the surgical importance of differentiating retropharyngeal cervical neuroblastomas from laterocervical neuroblastomas and to present their clinical and therapeutic characteristics. REPORT OF A CASEA 6-week-old boy was hospitalized with a 1-week history of progressively worsening inspiratory dyspnea and stridor, without any associated feeding problems. There was no family history of neurocristopathy. The clinical examination and endoscopy with the patient under general anesthesia showed a swelling of the left side of the pharynx, covered with normal mucosa, forcing the larynx forward and descending down into the hypopharynx. The mobility of the larynx was normal. Cervical palpation revealed no abnormalities. A left Horner syndrome and a heterochromia iridis were noted. A lateral cervical radiograph showed a pharyngeal tumor forcing the larynx forward (Figure 1). A cervical computed tomographic (CT) scan revealed a welldefined heterogeneous mass, with a few calcifications, that was in contact with the internal carotid artery and the prevertebral area and was reducing the airway (Figure 2). Blood tests were negative for chorionic gonadotropin ␤, carcinoembryonic antigen, ␣-fetoprotein, neuronspecific enolase, and urinary catecholamines. At the age of 8 weeks, the patient was surgically treated because of increasing difficulty in breathing. A transoral approach was used, and a L-shaped incision in the pharyngeal mucosa was performed. The tumor was well defined. The vascular pedicles of the tumor were electrocoagulated. The excision was macroscopically complete. The pharyngeal mucosa was sutured. The patient underwent extubation on awakening, and no dyspnea was observed.Microscopically, the tumor consisted of small, round and fusiform cells, which were only slightly larger than lymphocytes (Figure 3). They were arranged in irregular sheets separated by fibrovascular strands. In well-preserved areas, the cells were larger, with fewer chromatic nuclei, and arranged in round aggregates. There were no true rosettes. The background was loosely fibrillar. On immunohistochemical studies, the tumor cells expressed neuron-specific enolase and synaptophysin. The histologic diagnosis was neuroblastoma.For 8 days, the patient was fed with a nasogastric tube. A control fiberoscopy at day 8 showed complete healing. Oral feeding was resumed without any problems. Iobenguane sulfate I 123 scintigraphy perfor...

show abstract

Cervical neuroblastoma in eleven infants —a tumor with favorable prognosis

et al. 1993

View full text Add to dashboard Cite

Cervical neuroblastoma, a disease primarily of infants, has a favorable prognosis. Eleven patients are reported. Clinical presentations (other than mass) included stridor and swallowing problems. Masses when felt were commonly mistaken for infectious adenitis. Imaging studies (US, CT, MRI) showed solid masses with vascular displacement and narrowing; intraspinal extension was absent though extension into the adjacent sites of mediastinum and skull occurred. Horner syndrome was seen in five patients with accompanying heterochromia iridis in one. Five tumors had calcification. A high index of suspicion will lead to biopsy and less delay in diagnosis once a mass is felt or imaged.

show abstract

A rational approach to cervical neuroblastoma

Cited by 19 publications

References 9 publications

Localized cervical neuroblastoma: prevention of surgical complications

Localized cervical neuroblastoma: prevention of surgical complications

Primary Retropharyngeal Neuroblastoma

Cervical neuroblastoma in eleven infants —a tumor with favorable prognosis

Contact Info

Product

Resources

About