A ratiometric theranostic system for visualization of ONOO⁻ species and reduction of drug-induced hepatotoxicity

Abstract

Peroxynitrite (ONOO–) is a potent reactive nitrogen species that plays a critical mediator in liver injury elicited by drugs such as acetaminophen (APAP). At a therapeutic dosage, most APAP is...

Visualizing intracellular dynamics with AIE probes

“…5A). 47 ATV-PPB localizes in the mitochondria in the absence of peroxynitrite, and green fluorescence could be observed in the lipid droplets when peroxynitrite is formed. As displayed in Fig.…”

Recent Progress of Small‐Molecule Ratiometric Fluorescent Probes for Peroxynitrite in Biological Systems

“…Tang's group designed and synthesized an aggregation‐induced emission (AIE) ratiometric fluorescent probe 12 (Figure 3) for monitoring ONOO − fluctuations and relieving drug‐induced liver injury [56] . The triphenylamine group combined with a phenyl borate ester by pyridine enhanced the donor–acceptor interaction of the probe.…”

A therapeutic probe for detecting and inhibiting ONOO− in senescent cells

“…5,6 It is well known that ONOO − is generally considered to be the reaction product of nitric oxide (NO˙) and superoxide anion (O 2 ˙ − ) and participates in a variety of cellular processes, including inflammation, apoptosis, and necrosis (Scheme 1A). 7–11 In addition, ONOO − has strong oxidation and nitrification capacity in the life system, so various important biological molecules are easily destroyed or oxidized, which causes irreversible damage to DNA, lipids and proteins. 12–16 Meanwhile, it has been proved that an abnormal level of ONOO − may lead to a variety of diseases, such as cardiovascular diseases, inflammatory diseases/diabetes, Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer, and other diseases.…”