A ratiometric fluorescent probe for highly selective and sensitive detection of hypochlorite based on the oxidation of N-alkylpyridinium

Wang, Lin; Long, Lingliang; Zhou, Liping; Wu, Yujuan; Zhang, Chi; Han, Zhixiang; Wang, Junli; Da, Zulin

doi:10.1039/c4ra10633d

Cited by 42 publications

(8 citation statements)

References 59 publications

(8 reference statements)

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“…(Fig. 12), for HOCl detection in 20 mM phosphate buffer of pH 7.4 (H2O/THF = 1/3, v/v) [233]. In the presence of HOCl, N-alkylpyridinium can be oxidized to N-alkylpyridone.…”

Section: Esiptmentioning

confidence: 99%

Bioanalytical methods for hypochlorous acid detection: Recent advances and challenges

Zhang

Song

Yuan

2018

TrAC Trends in Analytical Chemistry

217

115

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Hypochlorous acid (HOCl), a well-known universal disinfectant in clinical practice, plays important roles in immune systems of animal and human bodies. For understanding the roles of HOCl in living systems, a number of approaches, including chemiluminescence, colorimetric, electrochemical and chromatographic methods have been explored. For the detection of HOCl in live organisms, cuttingedge techniques, such as fluorescence/phosphorescence molecular probes, responsive nanoprobes, Raman and activatable photoacoustic sensors, have also been developed recently. In this review, the recent advances in the development of bioanalytical methods for detection of HOCl in environmental and biological specimens were summarized. More specifically, traditional techniques for assay of HOCl in bulk solution were initially discussed, and then fluorescence molecular probes, phosphorescence probes, responsive nanoprobes and other methods for HOCl detection were reviewed, which gives an overview of the developments and applications in bioanalytical methods for HOCl detection.

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“…(Fig. 12), for HOCl detection in 20 mM phosphate buffer of pH 7.4 (H2O/THF = 1/3, v/v) [233]. In the presence of HOCl, N-alkylpyridinium can be oxidized to N-alkylpyridone.…”

Section: Esiptmentioning

confidence: 99%

Bioanalytical methods for hypochlorous acid detection: Recent advances and challenges

Zhang

Song

Yuan

2018

TrAC Trends in Analytical Chemistry

217

115

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“…In 2014, a group led by Wang synthesized a switch probe based on coumarin (compound (V); Fig. 6) [59]. For the first time, N-alkylpyridinium, which is oxidized to N-alkylpyridone under the effect of HOCl, was used as the recognition site in this sensor.…”

Section: Transition To the Switch Probe Conceptmentioning

confidence: 99%

Fluorescent Probes for HOCl Detection in Living Cells

Reut

Gorudko²,

Grigorieva³

et al. 2022

Russ J Bioorg Chem

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Hypochlorous acid (HOCl) plays an important role in the immune system not only protecting the organism from pathogens, but also, due to its high reactivity, provoking the development and complication of many diseases. Therefore, the development of highly sensitive and selective HOCl biosensors, including fluorescent probes, to better understand the roles of HOCl in living systems, is of great importance. Nevertheless, there are many difficulties associated with HOCl registration in biological probes (chemo-and photostability, cytotoxicity, fluorescence and absorption characteristics, selectivity, sensitivity, etc.). Thus, the development of new chemosensors has been relevant for many years. In this review, we describe classification of smallmolecule probes for HOCl detection in biological systems, as well as summarize the results of the development of chemosensors, their photophysical properties, and biological applications. Particular attention is paid to the achievements in this area over the years 2016-2021. A number of problems related to the design and application of small-molecule probes are formulated. Due to the absence of a "gold standard" among the HOCl chemosensors, which is associated with the commercial unavailability or complex methods of synthesis of new sensors as well, some recommendations are given regarding the field of the chemosensor application. Trends in the development of fluorescent chemosensors for HOCl visualization in living cells are outlined.

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“…Hypochlorite anion (ClO − ) plays an essential role in biological organisms and environmental monitors, which not only is produced by H 2 O 2 and chloride ions in activated neutrophils [ 1 , 2 , 3 , 4 , 5 ] but is also a kind of disinfector which can kill the coronavirus [ 6 , 7 , 8 ]. However, excessive hypochlorite could lead to diseases and even cancer including cardiovascular diseases, neuron degeneration, and arthritis [ 9 , 10 ]. Therefore, quantitative detection of hypochlorite with highly sensitive and selective methods becomes more and more crucial.…”

Section: Introductionmentioning

confidence: 99%

A Flexible Chemosensor Based on Colorimetric and Fluorescent Dual Modes for Rapid and Sensitive Detection of Hypochlorite Anion

Tao

Zhao

et al. 2021

Sensors

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A flexible chemosensor has been developed based on colorimetric and fluorescent dual modes using tetraphenylethylene-centered tetraaniline (TPE4A) for rapid and sensitive detection of hypochlorite anion. The fluorescent probe TPE4A exhibits a unique aggregation-induced emission (AIE) character which is proved by a blue shift of the fluorescent peak from 544 to 474 nm with the water equivalents increasing. With the addition of hypochlorite in solution, the absorbance of the probe changes and the responding fluorescence color can be observed to change from light green to purple. The detection limit of hypochlorite is 1.80 × 10−4 M in solution, and the visual detection limit is 1.27 µg/cm2 with the naked eye for the flexible paper-based chemosensor. The proposed flexible chemosensors show a good selectivity and sensitivity which has great potential for effective detection of hypochlorite anions without any spectroscopic instrumentation.

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A ratiometric fluorescent probe for highly selective and sensitive detection of hypochlorite based on the oxidation of N-alkylpyridinium

Cited by 42 publications

References 59 publications

Bioanalytical methods for hypochlorous acid detection: Recent advances and challenges

Bioanalytical methods for hypochlorous acid detection: Recent advances and challenges

Fluorescent Probes for HOCl Detection in Living Cells

A Flexible Chemosensor Based on Colorimetric and Fluorescent Dual Modes for Rapid and Sensitive Detection of Hypochlorite Anion

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