A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles.

Howie, Donald W.; Vernon‐Roberts, B.; Oakeshott, R. D.; Manthey, B

doi:10.2106/00004623-198870020-00015

Cited by 360 publications

(111 citation statements)

References 0 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…The resulting bone loss will enlarge the interface and ease the flow of joint fluid, resulting in higher transportation capacity of the debris and gradual loosening of the implant. Harris et al 1976Willert 1977 PE-particle Howie et al 1988 Metal-particle August 1986 Micromotion Ryd and linder 1989 Stress shielding Engh and Bobyn 1988 High fluid pressure Linder 1994Aspenberg and Van der Viis 1998Endotoxin Ragab et al 1999 Individual variations Matthews et al 2000 Sealed interface Schmalzried et al 1992 Various theories during the years regarding aseptic loosening Support for the above theory concerning effective joint space comes from the authors' own study on cemented acetabular components retrieved at autopsy (Schmalzried et al 1992b). Autopsy studies are important, since the well-functioning implant can be studied when no secondary changes such as osteoporosis and osteolysis have appeared.…”

Section: Theories Of Aseptic Looseningmentioning

confidence: 99%

“…However, as shown in Table, the amounts and sizes of particles have varied between the different studies (Howie et al 1988, Goodman 1994, Bobyn et al 1995, Dowd et al 1995, Frökjaer et al 1995, Goodman et al 1995, 1999, Kraemer et al 1995, Allen et al 1996, Aspenberg and Herbertsson 1996, Shanbhag et al 1997, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, 2001, Bechtold et al 2001, Bi et al 2001b, Sundfeldt et al 2002. The time of introduction of the particles and the design of the studies also varied greatly.…”

Section: Particle Diseasementioning

confidence: 99%

“…The surface of the PE must be as smooth as possible in order to reduce friction and wear against the femoral head or femoral condyles. Howie et al (1988) presented a study in rats in which a plug of polymethylmethacrylate was inserted into each femur and then exposed to ultrahigh-molecular-weight polyethylene particles 2, 4, 6 and 8 weeks after insertion. The aim was to mimic the bone-cement interface in cemented implants.…”

Section: Polyethylenementioning

confidence: 99%

“…It is very difficult to make any clear connection between PE particles and bone resorption based on animal studies (Howie et al 1988, Søballe et al 1992, Bobyn et al 1995, Dowd et al 1995, Allen et al 1996, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, Sundfeldt et al 2002.…”

Section: Polyethylenementioning

confidence: 99%

See 3 more Smart Citations

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

View full text Add to dashboard Cite

Section: Theories Of Aseptic Looseningmentioning

confidence: 99%

Section: Particle Diseasementioning

confidence: 99%

Section: Polyethylenementioning

confidence: 99%

Section: Polyethylenementioning

confidence: 99%

See 2 more Smart Citations

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

View full text Add to dashboard Cite

“…These are less than 10µm in size and potentially consist of metal, ceramic, cement or polyethylene. Some particulate debris can penetrate the interface between prosthesis and bone, stimulating the cellular response leading to osteolysis (10). It was once thought that cement particles caused the lytic process and this motivated the introduction of cementless THR.…”

Section: Introductionmentioning

confidence: 99%

Automated assessment of polyethylene wear in cemented acetabular components using anteroposterior radiographs of total hip replacements

Kerrigan

McKenna

Ricketts

et al. 2008

Computerized Medical Imaging and Graphics

View full text Add to dashboard Cite

Polyethylene wear in the acetabular components of hip prostheses is implicated in loosening and failure. Radiographic measurement of wear is used to identify patients at risk and to assess prosthesis designs. This paper focuses on analysis of prostheses with cemented acetabular cups from anteroposterior radiographs. The articular surface of the femoral head and the acetabular rim marker are modelled as spherical and circular respectively, resulting in elliptical image projections. Methods for automatically localising these structures in radiographs are presented using robust ellipse fitting and various error functions. Special attention is paid to the acetabular marker since this often projects as a highly eccentric ellipse. Robust fitting enables successful localisation in the presence of clutter without the need for user interaction. Finally, the use of these ellipses as reference structures for wear estimation is investigated and the effect of eccentricity errors is highlighted.

show abstract

Migration of metal and polyethylene particles from articular prostheses may generate lymphadenopathy with histiocytosis

Basle

Bertrand

Guyétant

et al. 1996

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Wear particles released from hip or knee prostheses are known to be involved in the fibrohistiocytic membrane interposed between bone and implant. During surgical treatment for pelvic carcinoma (5 cases) and for isolated pseudomalignant lymphadenopathy (4 cases) lymph nodes in 9 patients who had had lower limb articular replacement were harvested. Light microscopy and image analysis of the nodes showed florid endosinusal histiocytosis, predominant in the cortical area. Using Oil Red O staining and polarized light, metal particles and polyethylene particles were detected in the large histiocytes. Scanning electron microscopy with electron backscattering allowed us to localize metal particles and perform elemental microanalysis. Iron, cobalt, chromium, nickel, zirconium, and barium, known to be used in prosthetic and cementing materials, were identified as component of these particles. Large amounts of polyethylene particles appeared in all cases while metal particles were found to be abundant in only 2 cases. Thus, migration of polyethylene debris from the prosthetic site seems to be the major factor in development of the histiocytes induced in satellite lymph nodes.

show abstract

A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles.

Cited by 360 publications

References 0 publications

Aseptic loosening, not only a question of wear: A review of different theories

Aseptic loosening, not only a question of wear: A review of different theories

Automated assessment of polyethylene wear in cemented acetabular components using anteroposterior radiographs of total hip replacements

Migration of metal and polyethylene particles from articular prostheses may generate lymphadenopathy with histiocytosis

Contact Info

Product

Resources

About