A rat model of enhanced glycation mimics cardiac phenotypic components of human type 2 diabetes : A translational study using MRI

Castelhano, João; Ribeiro, Bruno Niemeyer de Freitas; Sanches, Mafalda; Graça, Bruno; Saraiva, Joana; Oliveiros, Bárbara; Neves, Christian; Rodrigues, Tiago; Gonçalves, S.I.; Ferreira, Maria João; Seiça, Raquel; Matafome, Paulo

doi:10.1016/j.jdiacomp.2020.107554

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Despite the low impact on the metabolic profile, early glycotoxin exposure promotes cardiac dysfunction, leading to lower developed intraventricular pressure, but with no differences in the response to local ischemia. Previous studies have evaluated the effects of glycotoxin exposure on cardiac health over the lifespan [37,38]. Crisóstomo and colleagues [10] demonstrated that chronic administration of MG induces diabetes-like cardiomyopathy in the hearts of Wistar rats and leads to lower AKT activation in ischaemicreperfusion hearts.…”

Section: Discussionmentioning

confidence: 99%

Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats

Ferreira-Junior,

Cavalcante,

Costa

et al. 2024

Nutrients

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Background: Though maternal diabetes effects are well described in the literature, the effects of maternal diabetes in postnatal phases are often overlooked. Diabetic individuals have higher levels of circulating glycotoxins, and there is a positive correlation between maternal-derived glycotoxins and circulating glycotoxins in their progeny. Previous studies evaluated the metabolic effects of high glycotoxin exposure during lactation in adult animals. However, here we focus on the cardiovascular system of juvenile rats. Methods: For this, we used two experimental models: 1. High Methylglyoxal (MG) environment: pregnant Wistar rats were injected with PBS (VEH group) or Methylglyoxal (MG group; 60 mg/kg/day; orally, postnatal day (PND) 3 to PND14). 2. GLO-1 inhibition: pregnant Wistar rats were injected with dimethyl sulfoxide (VEH group) or a GLO-1 inhibitor (BBGC group; 5 mg/kg/day; subcutaneously, PND1–PND5). The offspring were evaluated at PND45. Results: MG offspring presented cardiac dysfunction and subtly worsened vasomotor responses in the presence of perivascular adipose tissue, without morphological alterations. In addition, an endogenous increase in maternal glycotoxins impacts offspring vasomotricity due to impaired redox status. Conclusions: Our data suggest that early glycotoxin exposure led to cardiac and vascular impairments, which may increase the risk for developing cardiovascular diseases later in life.

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Section: Discussionmentioning

confidence: 99%

Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats

Ferreira-Junior,

Cavalcante,

Costa

et al. 2024

Nutrients

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“…Thus, this study aims to evaluate the effect of functional bread with RSV in preventing early type-2-diabetes-induced cardiac remodeling through functional, histological, and molecular evaluations of cardiac muscle in a non-genetic rat model. Fructose-fed plus STZ-injected rats were used as a preclinical model of type 2 diabetes since it is cost-effective, easy to develop, and displays the same heart clinical features (e.g., stroke volume (SV) and peak filling rate (PFR) echography parameters, hypertrophy, and fibrosis) observed in humans with prediabetes [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Resveratrol-Enriched Bread on Cardiac Remodeling in a Preclinical Model of Diabetes

et al. 2023

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The World Health Organization aims to stop the rise of diabetes by 2025, and diet is one of the most efficient non-pharmacological strategies used to prevent it. Resveratrol (RSV) is a natural compound with anti-diabetic properties, and incorporating it into bread is a suitable way to make it more accessible to consumers as it can be included as part of their daily diet. This study aimed to evaluate the effect of RSV-enriched bread in preventing early type 2 diabetes cardiomyopathy in vivo. Male Sprague Dawley rats (3 weeks old) were divided into four groups: controls with plain bread (CB) and RSV bread (CBR), and diabetics with plain bread (DB) and RSV bread (DBR). Type 2 diabetes was induced by adding fructose to the drinking water for two weeks followed by an injection of streptozotocin (STZ) (40 mg/kg). Then, plain bread and RSV bread (10 mg RSV/kg body weight) were included in the rats’ diet for four weeks. Cardiac function, anthropometric, and systemic biochemical parameters were monitored, as well as the histology of the heart and molecular markers of regeneration, metabolism, and oxidative stress. Data showed that an RSV bread diet decreased the polydipsia and body weight loss observed in the early stages of the disease. At the cardiac level, an RSV bread diet diminished fibrosis but did not counteract the dysfunction and metabolic changes seen in fructose-fed STZ-injected rats.

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A rat model of enhanced glycation mimics cardiac phenotypic components of human type 2 diabetes : A translational study using MRI

Cited by 2 publications

References 46 publications

Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats

Early Methylglyoxal Exposure Leads to Worsened Cardiovascular Function in Young Rats

The Impact of Resveratrol-Enriched Bread on Cardiac Remodeling in a Preclinical Model of Diabetes

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