A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Takano, Yuji; Yokawa, Takashi; Masuda, Asami; Niimi, Jun; Tanaka, Satoshi; Hironaka, Naoyuki

doi:10.1016/j.neulet.2011.01.004

Cited by 75 publications

(59 citation statements)

References 22 publications

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“…In this phase, four studies were excluded: one study used tDCS in mouse slices, thus not characterizing in vivo assessment (Fritsch et al , 2010 ); three studies delivered non-constant currents (Kabalak et al , 2005 ;Nekhendzy et al , 2006 ;Ozen et al , 2010 ). The study by Nekhendzy et al (2004) healthy animals, measuring its effects on cerebral blood fl ow (Wachter et al , 2011 ), motor excitability (Cambiaghi et al , 2010 ), neuroimaging (Takano et al , 2011 ), safety limits of electric charges (Liebetanz et al , 2009 ) and visual attention task (Schweid et al , 2008 ), or in pathologic models of stroke (Kim et al , 2010 ), epilepsy (Liebetanz et al , 2006b ;Kamida et al , 2011 ), cortical spreading depression (Liebetanz et al , 2006a ;Fregni et al , 2007 ), cerebellar lesion (Ben Taib and Manto , 2009 ) and pain (Nekhendzy et al , 2004 ) (Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Translational research in transcranial direct current stimulation (tDCS): a systematic review of studies in animals

Brunoni¹,

Fregni

Pagano

2011

Revneuro

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Recent therapeutic human studies testing transcranial direct current stimulation (tDCS) has shown promising results, although many questions remain unanswered. Translational research with experimental animals is an appropriate framework for investigating its mechanisms of action that are still undetermined. Nevertheless, animal and human studies are often discordant. Our aim was to review tDCS animal studies, examining and comparing their main findings with human studies. We performed a systematic review in Medline and other databases, screening for animal studies in vivo that delivered tDCS. Studies in vitro and using other neuromodulatory techniques were excluded. We extracted data according to Animal Research: Reporting In Vivo Experiments (ARRIVE) guidelines for reporting in vivo animal research. Thus, we collected data on sample characteristics (size, gender, weight and specimen) and methodology (experimental procedures, experimental animals, housing and husbandry, as well as analysis). We also collected data on methods for delivering tDCS (location, size, current and current density of electrodes and electrode montage), experimental effects (polarity-, intensity- and after-effects) and safety. Only 12 of 48 potentially eligible studies met our inclusion criteria and were reviewed. Quality assessment reporting was only moderate and studies were heterogeneous regarding tDCS montage methodology, position of active and reference electrodes, and current density used. Nonetheless, almost all studies demonstrated that tDCS had positive immediate and long-lasting effects. Vis-à-vis human trials, animal studies applied higher current densities (34.2 vs. 0.4 A/m(2), respectively), preferred extra-cephalic positions for reference electrodes (60% vs. 10%, respectively) and used electrodes with different sizes more often. Potential implications for translational tDCS research are discussed.

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Section: Resultsmentioning

confidence: 99%

Translational research in transcranial direct current stimulation (tDCS): a systematic review of studies in animals

Brunoni¹,

Fregni

Pagano

2011

Revneuro

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“…In an animal study, anodal stimulation on frontal cortex induced neuronal activation in the frontal cortex and its associated brain regions [69]. In human studies, when anodal stimulation was applied to dorsolateral prefrontal cortex, the synchrony in the anticorrelated network components increased and the synchrony in the default mode network components decreased, which means that the intrinsic brain activity network reconfiguration occurred after tDCS [70].…”

Section: Modulation Of Functional Connectivitymentioning

confidence: 99%

Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

Kim

2017

Brain Neurorehabil

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Highlights• Transcranial direct current stimulation (tDCS) is a method of brain stimulation emerging as an alternative treatment of various neurological diseases.• Although tDCS affects cognitive function improvement in non-human studies, clinical trial results are still inconsistent.• This review provides an overview of the effects of tDCS on Alzheimer's disease. ABSTRACTTranscranial direct current stimulation (tDCS) is one of the brain stimulation techniques, which considered as an alternative treatment for Alzheimer's disease (AD). In AD, cognitive, behavior, and functional deteriorations are the result of synaptic dysfunction, neural circuit destabilization, and disrupted network activity, which are mainly caused by amyloid and tau deposition. tDCS modified neuronal resting membrane potential, synaptic plasticity, cortical neurotransmitters, astrocytes, cerebral blood flow, and functional connectivity, which could restore cognitive impairment. However, several small clinical studies that have been conducted so far have produced inconsistent results in patients with AD. Therefore, more systematic clinical studies are needed in the future.

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“…During the 20-minute session of anodal tDCS, the animals remained gently wrapped in a towel. The anodal electrode was placed between the ears, on the neck of the rat (parietal cortex), and the cathodal electrode was positioned at the midpoint between the lateral angles of both eyes (supraorbital area) 18,19,25 . This technique mimics tDCS protocols used in humans 26,27 , and it has been applied by our research group showing antinociceptive effects 18,19 .…”

Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 99%

Evaluation of different procedure involved in the Transcranial Direct Current Stimulation (tDCS) technique experimental application

Adachi¹,

Oliveira²,

Vercelino³

et al. 2017

Clin. Biomed. Res.

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Introduction: The transcranial direct current stimulation (tDCS) is a non-invasive technique, which induces neuroplastic changes in the central nervous system of animals and humans. Furthermore, tDCS has been suggested as a therapeutic tool for pain management. The aim of this study was to standardize a non-invasive tDCS technique indexed by the nociceptive response of rats submitted to different conditions necessary to the tDCS application.

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A rat model for measuring the effectiveness of transcranial direct current stimulation using fMRI

Cited by 75 publications

References 22 publications

Translational research in transcranial direct current stimulation (tDCS): a systematic review of studies in animals

Translational research in transcranial direct current stimulation (tDCS): a systematic review of studies in animals

Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

Evaluation of different procedure involved in the Transcranial Direct Current Stimulation (tDCS) technique experimental application

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